Searchable abstracts of presentations at key conferences in endocrinology

ea0008s28 | Neuroendocrine Tumours | SFE2004

Surgical Aspects of Medullary Thyroid Cancer Treatment

Harrison B

Adult and paediatric patients with Medullary Thyroid Cancer (MTC) may present in a variety of clinical scenarios. These include patients with a neck mass and 'apparently' sporadic disease or the index case of genetically determined disease (MEN2A/2B or FMTC), individuals from known MTC kindred who may be symptomatic or screen detected (either gene positive with an elevated basal / stimulated calcitonin, or gene positive and normocalcitonaemic) and patients with recurrent disea...

ea0007p119 | Endocrine tumours and neoplasia | BES2004

Bilateral laparoscopic adrenalectomy for ACTH-dependent Cushing's syndrome

Newell-Price J , Gandhi A , Harrison B

Background: Management of ACTH-dependent Cushing's syndrome (ACTH-CS) remains a challenge. In the past 2 decades open bilateral adrenalectomy, associated high morbidity and long post-operative in-patient stay, has usually been reserved for cases of failed transsphenoidal surgery (TpS) and radiotherapy (RT), or where the source of ACTH is not found. Laparoscopic adrenalectomy is a significant advance with low morbidity and mortality.Aim: To assess the eff...

ea0007oc28 | Endocrine tumours | BES2004

Biochemical and genetic screening in isolated and familial MEN1

Lee S , Roper E , Kirk R , Howie H , Doane A , Quarrell O , Harrison B , Ross R

Background: Multiple endocrine neoplasia type 1 (MEN1) is an inherited cancer syndrome characterized by the development of tumours in at least two of the following three main sites: parathyroid, pituitary and endocrine pancreas. Hyperparathyroidism is the most common presenting feature, with a typical age at onset of 20-25 years, and > 90% penetrance by 40 years. After extended family studies, an index case may have no affected relatives and be apparently 'isolated'. We rep...

ea0027p28 | (1) | BSPED2011

Prophylactic thyroidectomy in children with MEN2 in the United Kingdom

Prete Francesco Paolo , Morkane Clare , Watkinson J , Shaw N , Alvi S , Squire R , Harrison B , Wales J , Clayton P , Morrison P , Carson D , Brain C , Hindmarsh P , Dattani M , Spoudeas H , Buchanan C , Albanese A , Amin R , Piero A , Kurzawinski T

Introduction: Timing, extent, complications rate and long term results of paediatric prophylactic thyroidectomy (pPT) for MEN2 in the UK are unknown.Methods: All UK centers performing pPT were invited to participate in the study.Data were obtained from notes and hospitals electronic databases.Results: Fifty-one children (27 males) were included.All had genetic test at the mean age of 5 years (median 3, range 0.25–15), confirmi...