Searchable abstracts of presentations at key conferences in endocrinology
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195th Meeting of the Society for Endocrinology joint with Diabetes UK and the Growth Factor Group

Oncology Strand

Neuroendocrine Tumours

ea0008s25 | Neuroendocrine Tumours | SFE2004


Grossman AB

Neuroendocrine tumours (NETs) are usually taken to include gastro-enterohepatic tumors including islet cell tumours and carcinoids; recent data suggest an overall incidence of around 30/million/year, but since such tumours usually present late curative surgery is rarely an option and chemotherapy of limited benefit. Radionuclide scintigraphy with somatostatin (SMS) analogues such as 111In-octreotide demonstrate the presence of SMS receptors in some 80%-90% of NETS; we have use...

ea0008s26 | Neuroendocrine Tumours | SFE2004

New Genetic Causes of Pheochromocytoma

Neumann H

Pheochromocytoma can present as a sporadic or familial tumor. Classic syndromes include multiple endocrine neoplasia type 2 caused by mutations of the RET gene, Von Hippel-Lindau disease by mutations of the VHL gene and neurofibromatosis by mutations of the NF 1 gene. In 2000 for familial neck paraganglioma the susceptibility gene of succinatedehydrogenasis subunit D, SDHD was identified and subsequently also shown to be mutated in a subset of familial and sporadic pheochromoc...

ea0008s27 | Neuroendocrine Tumours | SFE2004

Genotype-Phenotype Correlations in von Hippel-Lindau disease

Maher ER

Von Hippel-Lindau (VHL) disease is a dominantly inherited familial cancer syndrome characterised by a predisposition to retinal and cerebellar haemangioblastomas, renal cell carcinoma (RCC) and renal cysts, phaeochromocytoma and, less frequently, pancreatic islet cell tumours. Although rare, VHL disease provides a paradigm for illustrating the clinical features and significance of familial cancer syndromes and how the molecular genetic analysis of rare inherited cancers can pr...

ea0008s28 | Neuroendocrine Tumours | SFE2004

Surgical Aspects of Medullary Thyroid Cancer Treatment

Harrison B

Adult and paediatric patients with Medullary Thyroid Cancer (MTC) may present in a variety of clinical scenarios. These include patients with a neck mass and 'apparently' sporadic disease or the index case of genetically determined disease (MEN2A/2B or FMTC), individuals from known MTC kindred who may be symptomatic or screen detected (either gene positive with an elevated basal / stimulated calcitonin, or gene positive and normocalcitonaemic) and patients with recurrent disea...