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SFE2004
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195th Meeting of the Society for Endocrinology joint with Diabetes UK and the Growth Factor Group
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Summary
Abstracts
Contents
Plenary Lectures
Society for Endocrinology Asia and Oceania Medal Lecture
RNA, proteins and hormone action: tales from down under
ea0008s1
Society for Endocrinology Asia and Oceania Medal Lecture
ea0008s1biog
Society for Endocrinology European Medal Lecture
Neuroendocrine tumors: From bench to bed - 25 years experience and the future
ea0008s2
Society for Endocrinology European Medal Lecture
ea0008s2biog
Society for Endocrinology Medal
Oestrogen and the skeleton
ea0008s3
Society for Endocrinology Medal Lecture
ea0008s3biog
Basic Science Review Lecture
Basic Science Review Lecture
Understanding endocrine development of the human beta cell: guiding stem cell therapy for Type 1 Diabetes
ea0008s4
Symposia
Zonation of the adrenal cortex�molecular signalling
Functional zonation of the adrenal cortex - an overview
ea0008s5
Wnt signalling in the adrenal cortex
ea0008s6
Adrenomedullin in the adrenal
ea0008s7
Paracrine regulation of the adrenal cortex
ea0008s8
Stressed mothers: Causes and outcomes
OXYTOCIN AND THE CROSS-GENERATIONAL TRANSMISSION OF MOTHERING AND STRESS RESPONSES
ea0008s9
Reproductive hormones: Involvement in maternal stress coping and anxiety
ea0008s10
EFFECTS OF PRE-NATAL STRESS ON BEHAVIOUR AND NEUROENDOCRINE ACTIVITY OF PIGS' OFFSPRING
ea0008s11
Endocrine-immune bidirectionality in pregnancy: effects of stress and anxiety
ea0008s12
Hormones in natural products
Hormones in natural products: an overview
ea0008s13
Natural endocrine disrupters in aquatic environments
ea0008s14
Gender dysfunction in newborn males
ea0008s15
Phytoestrogens - beyond the oestrogen receptor
ea0008s16
Consequences of a lack of androgens
ANDROGEN ACTION AND THE MALE ADULT PHENOTYPE FROM YOUTH TO SENESCENCE
ea0008s17
CONSEQUENCES OF ANDROGEN RECEPTOR ABNORMALITIES
ea0008s18
SARMS(Selective androgen receptor modulators)
ea0008s19
Hormonal Male Contraception: An Update
ea0008s20
Nurses Session
Neuroendocrine tumours-an update
Introduction to NET: Definition, classification and diagnosis
ea0008s21
The Role of the Nurse Specialist in the Co-ordination of Patient Care
ea0008s22
Injection techniquesndashgetting it right
ea0008s23
A case of MEN 1 syndrome with secretion of multiple gut hormones
ea0008s24
Oncology Strand
Neuroendocrine Tumours
THE MANAGEMENT OF NEUROENDOCRINE TUMOURS WITH RADIOACTIVE OCTREOTIDE
ea0008s25
New Genetic Causes of Pheochromocytoma
ea0008s26
Genotype-Phenotype Correlations in von Hippel-Lindau disease
ea0008s27
Surgical Aspects of Medullary Thyroid Cancer Treatment
ea0008s28
Endocrine aspects of breast cancer
New Pure Antioestrogens
ea0008s29
The role of oestrogens in the development of breast cancer
ea0008s30
Endocrine treatment of breast cancer
ea0008s31
Exercise, obesity and the risk of breast cancer
ea0008s32
Oral Communications
Growth and Development
Rat bone marrow mesenchymal stem cells transdifferentiate into islet-secreting cells in vitro
ea0008oc1
Insulin transgene overexpression: a tool for characterisation of beta-cell phenotype in transdifferentiation studies
ea0008oc2
Cell-cell contact enhances insulin secretion from pancreatic beta-cells but not glucagon secretion from alpha-cells
ea0008oc3
IGF-independent acceleration of myogenesis by IGFBP-5: modulation of cell survival and differentiation signalling pathways
ea0008oc4
GnRH, anosmin-1 and FGFR1 immunoreactivity in the developing human brain
ea0008oc5
Overexpression of the imprinted gene Neuronatin represses normal pituitary differentiation
ea0008oc6
Sexually dimorphic glucocorticoid programming of the hypothalamo-pituitary-prolactin axis
ea0008oc7
Fetal programming of the endothelial nitric oxide pathway in man
ea0008oc8
Neuroendocrinology and Reproduction
Triiodothyronine Directly Regulates Feeding
ea0008oc9
Subcutaneous administration of ghrelin and its effects on food intake in man
ea0008oc10
Brain-derived neurotrophic factor (BDNF) is a novel steroidogenic factor-1 (SF-1) target gene in the ventromedial hypothalamus (VMH): implications for obesity onset
ea0008oc11
Macrophage migration inhibitory factor is released from pituitary folliculo-stellate-like cells by endotoxin and dexamethasone and attenuates the steroid-induced inhibition of interleukin 6 release
ea0008oc12
Reduced expression of anti-Mullerian hormone (AMH) protein in the androgenised sheep ovary
ea0008oc13
Sickle Cell trait and gender influence type 2 diabetic complications in African patients
ea0008oc14
PGF2alpha -FP receptor signalling is a potential regulator of endometrial vascular function
ea0008oc15
Sp1 and CREB promote nectin-2 transcription to regulate adherens junctions assembly in the testis
ea0008oc16
Young Endocrinologist Session
Regulation of canonical Wnt/beta-catenin signalling pathway plays a central role in the thyroid growth and proliferation in neoplastic thyroid cell lines
ea0008oc18
Proliferative effects of ghrelin and desoctanoyl ghrelin are independent of the growth hormone secretagogue receptor (GHS-R)
ea0008oc19
Sp1/Sp3, GnRH and PACAP involvement in C-type natriuretic peptide (CNP/Nppc) expression and action in gonadotrophs
ea0008oc20
FAILURE OF SUPPRESSION OF ENDOGENOUS GLUCOSE PRODUCTION (EGP) DIMINISHED LIPOLYSIS AND FREE FATTY ACID (FFA) OXIDATION IN A POPULATION AT HIGH RISK OF THE DEVELOPMENT OF TYPE 2 DIABETES
ea0008oc21
Effect of Variation at the Aldosterone Synthase Locus (CYP11B2) on Adrenal 11-beta hydroxylation: Pilot Data from the MRC BRIGHT Study
ea0008oc22
Adrenal and circulating agouti related protein (AgRP) is upregulated in Cushing's syndrome suggesting a novel inhibitory paracrine role in the human adrenal gland
ea0008oc23
A Pilot Study of Prolonged High Dose Rosiglitazone Therapy (12mg/day) in Nelson's Syndrome
ea0008oc24
Poster Presentations
Bone
The Effect of BsmI and FokI Genotypes on Bone Density and Bone Turnover Response to Raloxifene Therapy
ea0008p1
Serum 25 (OH) D and Dietary Calcium Intake are Associated with Bone Mineral Density Acquisition during Puberty
ea0008p2
Depot Medroxyprogesterone Acetate Use is Associated with a Bone Density Deficit in Young Adult Women
ea0008p3
Poor Health May Predict Vertebral Fractures but Not Non-vertebral Fractures
ea0008p4
The effects of Simvastatin on the human osteoblast-like cell, SaOS-2
ea0008p5
Clinical case reports
A young woman presenting with multiple bone swelling, deformities and fractures
ea0008p6
Anticoagulation related life threatening electrolyte imbalance in a patient with diabetes mellitus
ea0008p7
A sweet case of refractory hypokalaemia
ea0008p8
Conservative management of a visual field defect
ea0008p9
Hyperinsulinaemic Hypoglycaemia in a Pregnant Patient with Human Immunodeficiency Virus [HIV] Infection
ea0008p10
A rare mutation causing Familial Medullary Thyroid Carcinoma
ea0008p11
ADDISON'S DISEASE AND CYCLICAL NEUTROPENIA - A DEVASTATING COMBINATION
ea0008p12
Running out of sodium
ea0008p13
Euglycaemic Diabetic ketoacidosis in pregnancy
ea0008p14
Adrenal hypoplasia congenita and hypogonadotropic hypogonadism due to a novel splice site mutation in NR0B1
ea0008p15
Inducing weight loss with steroids: a case of neurosarcoidosis
ea0008p16
Cytokines and growth factors
SEMINAL PLASMA ACTIVATES SIGNALLING AND GENE EXPRESSION VIA THE EP4 RECEPTOR
ea0008p17
Modulation of the circulating insulin-like growth factor system in patients with gastrointestinal inflammation
ea0008p18
Age is an important determinant of the growth hormone response to sprint exercise in young men
ea0008p19
Low circulating ghrelin levels in gastrectomized patients do not affect the growth hormone response to insulin induced hypoglycemia
ea0008p20
MATERNAL COLD EXPOSURE FROM MID TO LATE GESTATION RESULTS IN INCREASED ADIPOSE INSULIN-LIKE GROWTH FACTOR (IGF)-I mRNA EXPRESSION AND HEAVIER BIRTH WEIGHT WITH NO EFFECT ON FAT MASS
ea0008p21
Somatostatin Abrogates GH-Induced Hepatocyte IGF-I Transcription by Inhibiting STAT5b Phosphorylation amp Nuclear Translocation
ea0008p22
Variability in IGF-I assay performance undermines its contribution to the management of GH axis disorders
ea0008p23
Exploiting Phage Technology for Targeting Gene Delivery into the CNS
ea0008p24
Diabetes, metabolism and cardiovascular
Interference of signal transduction pathways by Baicalin in insulinoma cell line and its biological significance
ea0008p25
Rat pancreatic stellate-like cells differentiate into neuron
ea0008p26
EFFECTS OF SYZYGIUM (i) CORDATUM (i) LEAF EXTRACT ON PLASMA GLUCOSE AND HEPATIC GLYCOGEN IN STREPTOZOTOCIN-INDUCED DIABETIC RATS
ea0008p27
Altered adrenomedullin (ADM) levels in the central nervous system (CNS) during acute experimental allergic encephalomyelitis (EAE)
ea0008p28
Differential effect of maternal nutrient restriction in early to mid and late gestation on uncoupling protein-2 mRNA abundance in adipose tissue of the resulting offspring
ea0008p29
EPIDEMIOLOGICAL STUDY ON GLYCEMIA CONTROL IN PATIENTS WITH DM1 AND DM2, Epicon study- baseline visit analysis
ea0008p30
METABOLIC EFFECTS OF ANDROGENIC STEROID ABUSE
ea0008p32
AUDIT OF MANAGEMENT OF DIABETIC KETOACIDOSIS IN A BUSY DISTRICT GENERAL HOSPITAL
ea0008p33
Increased insulin resistance is strongly associated with decreased physical quality of life in elderly subjects from the Hertfordshire Cohort Study, independent of established IHD
ea0008p34
Instant 99mTc-ciprofloxacin scintigraphy for the diagnosis of Osteomyelitis in the Diabetic foot
ea0008p35
Vasculopathy in Turner Syndrome: Arterial Dilatation and Intimal Thickening without Endothelial Dysfunction
ea0008p36
Increasing oestrogen dose reduces intima media thickness in women with Turner Syndrome
ea0008p37
CHARACTERISATION OF ADRENOMEDULLIN RECEPTOR (CRLR/RAMP2) EXPRESSION IN HUMAN MICROVASCULAR ENDOTHELIAL CELLS
ea0008p38
Comparing Daily Glycaemic Control with Insulin Glargine added to Oral Agents versus Twice-daily Premixed Insulin Alone in Type 2 Diabetes
ea0008p39
Evolution of insulin resistance in adolescent and young men
ea0008p40
The effects of maternal diet during late pregnancy and body shape at birth on postnatal plasma concentrations of insulin like growth factor 1 (IGF1) and leptin
ea0008p41
ELECTRON BEAM CT MEASUREMENT OF CORONARY ARTERY CALCIUM ALLOWS INDIVIDUAL RISK ASSESSMENT OF CHD IN UK DIABETIC PATIENTS
ea0008p42
Effect of ghrelin on insulin-stimulated glucose uptake in adipocytes and role of the growth hormone secretagogue receptor type 1a
ea0008p43
Endocrine Tumours and Neoplasia
Expression of Bone Morphogenetic Protein receptors in human pituitary adenomas
ea0008p44
Diagnosis of a gastrinoma in patients on proton pump inhibitor therapy
ea0008p45
Fractionated urinary metanephrines and the diagnosis of phaeochromocytoma
ea0008p46
Elevated FP receptor signalling in endometrial adenocarcinoma cells promotes expression of inflammatory and angiogenic genes via the EGFR and ERK1/2 pathways
ea0008p47
An audit of long-acting Somatostatin receptor ligand therapy in acromegaly
ea0008p48
HISTOPATHOLOGICAL SURPRISE IN A RADIOLOGICALLY PATIENT OF ACROMEGALY: SOMATOROPINOMA WITH NEURONAL CHORISTOMA
ea0008p49
Dramatic response with medical treatment of an extensively invasive 'giant' prolactinoma with cabergoline
ea0008p50
Prognostic value Carcinoembryonic antigen (CEA)of in patients with the familial medullary thyroid carcinoma (FMTC)
ea0008p51
Multiple hepatic embolisations are an effective treatment for metastatic gastrinoma
ea0008p52
Growth and development
An inducible gene expression model and expression microarray to determine regulators of human pancreatic beta cell differentiation
ea0008p53
Early development and subsequent metabolic parameters in Holstein-Friesian Dairy Cows
ea0008p54
Intermittent recombinant growth hormone (Saizen) treatment in short children born small for gestational age: Results of two different treatment regimens on growth parameters after 4 years
ea0008p55
The effect of thyroid hormone (T3) and a beta-adrenoceptor agonist on uncoupling protein 3 (UCP3) mRNA expression in porcine adipose tissue (AT)
ea0008p56
The influence of environmental temperature and hormonal manipulation on adipose tissue (AT) uncoupling protein (UCP) 3 expression in neonatal pigs
ea0008p57
11beta hydroxysteroid dehydrogenase type 2 (11betaHSD2) is expressed in omental fat of week old lambs
ea0008p58
Is the Bone Mineral Density of Adults with GH Deficiency and GH-Insufficiency Truly Reduced?
ea0008p59
Urokinase-type plasminogen activator: a novel ligand for anosmin-1, the protein implicated in X-linked Kallmann's syndrome
ea0008p60
Neuroendocrinology and behaviour
Stress hyporesponsiveness during pregnancy and parturition: sympathetic and adrenal medulla responses in rodents
ea0008p61
Gender and species barrier are linked in BSE transmission to mice
ea0008p62
Serum prolactin levels in patients with non-functioning pituitary adenomas and craniopharyngiomas
ea0008p63
A rare presentation of a neuroendocrine tumor
ea0008p64
Characterization of formylated peptide receptor expression in murine brain, pituitary and adrenal tissue
ea0008p65
A Comparative Growth Hormone Study in Acromegaly
ea0008p66
PITUITARY FUNCTION IN ADULTS TREATED FOR ACUTE LYMPHOBLASTIC LEUKAEMIA (ALL) DURING CHILDHOOD
ea0008p67
Management dilemmas in an Acromegalic twelve years after surgery for subarachnoid haemmorhage
ea0008p68
Prolactin secretion in the male annexin 1 knockout mouse: effects of gonadectomy and testosterone replacement
ea0008p69
Blood Cerebrospinal Fluid Barrier (BCB) for TSH, Prolactin and Insulin in Pregnancy
ea0008p70
Ghrelin increases food intake in obese as well as lean subjects
ea0008p71
The C terminal decapeptide from the Kisspeptin stimulates calcium transients in human FNCB4 GnRH expressing human olfactory neuroblasts
ea0008p72
Reproduction
Expression of 20alpha hydroxysteroid dehydrogenase in the adrenal cortex during pregnancy
ea0008p73
Effect of gonadotrophin and insulin on the balance of sterol regulatory element-binding protein(SREBP) isoforms in human granulosa cells
ea0008p74
Evidence for a role of the Type 1 IGF receptor in early follicular development in cultured human ovarian tissue
ea0008p75
VARIATION IN PITUITARY EXPRESSION OF BETAGLYCAN, ACTIVIN RECEPTOR SUBTYPES (TYPE I, IIA, IIB) AND GnRH RECEPTOR DURING THE OVULATORY CYCLE OF THE DOMESTIC HEN
ea0008p76
Do Androstenedione and DHEAS contribute to the diagnosis of PCOS in GP Patients?
ea0008p77
Androgens inhibit atresia and retard early development of ovarian follicles: a model for PCOS?
ea0008p78
CHANGES IN OVARIAN MODULATORS OF TYPE 1 11BETA-HYDROXYSTEROID DEHYDROGENASE (11BHSD1) ACTIVITY DURING PORCINE FOLLICULAR GROWTH
ea0008p79
Arterial viscoelastic properties and blood pressure in pregnant women with polycystic ovary syndrome
ea0008p80
Steroids
Discrepancy between random serum cortisol levels and short synacthen test results in a patient with adrenal insufficiency
ea0008p81
PHYTOESTROGENS INHIBIT mRNA EXPRESSION AND ACTIVITY OF AROMATASE IN HUMAN GRANULOSA-LUTEAL (GL) CELLS
ea0008p82
Familial Glucocorticoid Deficiency type 2 is associated with mutations in a novel gene encoding a small single transmembrane domain protein
ea0008p83
Patient self-monitoring of hydrocortisone replacement
ea0008p84
Glucocorticoid metabolism in fatty liver induced by a choline-deficient diet in mice
ea0008p85
Functional properties and utility of fusion proteins of type II 3beta-hydroxysteroid dehydrogenase and green fluorescent protein
ea0008p86
Variability in Hydrocortisone Pharmacokinetics Following Intravenous and Oral Administration in Patients with Adrenal Insufficiency
ea0008p87
Thyroid
Pitfalls of 99mTc-pertechnetate scintigraphy in Postpartum thyrotoxicosis
ea0008p88
Thyroid hemiagenesis associated with Graves' disease
ea0008p89
The Irrelevance of Anti-thyroid Peroxidase Antibodies
ea0008p90
Diabetes Strand
Lectures
Can we resurrect beta cell function? Insights from GLP-1
ea0008ds1
New insights into the pathogenesis of diabetic kidney disease
ea0008ds2
11beta-hydroxysteroid dehydrogenase type 1: a cause of the metabolic syndrome and therapeutic target
ea0008ds3
Symposium
Recent advances in drug delivery and monitoring
Update on Insulin Pump Therapy in the U.K
ea0008ds4
Continuous Glucose Monitoring
ea0008ds5
Alternative mechanisms of insulin delivery
ea0008ds6
Expert Sessions
Expert sessions
Diabetes, HDL metabolism and cardiovascular disease
ea0008ds7
Sexual Development
ea0008ds8
Poster Session
Diabetes, metabolism and cardiovascular
Anticoagulation related life threatening electrolyte imbalance in a patient with diabetes mellitus
ea0008dp1
Interference of signal transduction pathways by Baicalin in insulinoma cell line and its biological significance
ea0008dp2
Rat pancreatic stellate-like cells differentiate into neuron
ea0008dp3
Rat bone marrow mesenchymal stem cells transdifferentiate into islet-secreting cells in vitro
ea0008dp4
DIETARY COMPLIANCE OF PATIENTS WITH TYPE 2 DIABETES IN PRIMARY CARE IN GREATER NOTTINGHAM
ea0008dp5
Assessing the effects of dehydroepiandrosterone replacement on insulin sensitivity and skeletal muscle physiology in hypoadrenal women
ea0008dp6
METABOLIC EFFECTS OF ANDROGENIC STEROID ABUSE
ea0008dp7
AUDIT OF MANAGEMENT OF DIABETIC KETOACIDOSIS IN A BUSY DISTRICT GENERAL HOSPITAL
ea0008dp8
Increased insulin resistance is strongly associated with decreased physical quality of life in elderly subjects from the Hertfordshire Cohort Study, independent of established IHD
ea0008dp9
All men attending diabetes clinics should have serum testosterone measure as it correlates with HDL and sexual dysfunction
ea0008dp10
Hyperinsulinaemic Hypoglycaemia in a Pregnant Patient with Human Immunodeficiency Virus [HIV] Infection
ea0008dp11
Sickle Cell trait and gender influence type 2 diabetic complications in African patients
ea0008dp12
HISTOPATHOLOGICAL SURPRISE IN A RADIOLOGICALLY PATIENT OF ACROMEGALY: SOMATOROPINOMA WITH NEURONAL CHORISTOMA
ea0008dp13
Insulin secreted in response to high glucose prevents b-cells from undergoing apoptosis
ea0008dp14
A Pilot Study of Prolonged High Dose Rosiglitazone Therapy (12mg/day) in Nelson's Syndrome
ea0008dp15
Vasculopathy in Turner Syndrome: Arterial Dilatation and Intimal Thickening without Endothelial Dysfunction
ea0008dp16
Increasing oestrogen dose reduces intima media thickness in women with Turner Syndrome
ea0008dp17
Insulin transgene overexpression: a tool for characterisation of beta-cell phenotype in transdifferentiation studies
ea0008dp18
Cyclo-oxygenase 2 and prostaglandin E2 protect against apoptosis in MIN6 insulin-secreting cells
ea0008dp19
The effects of maternal diet during late pregnancy and body shape at birth on postnatal plasma concentrations of insulin like growth factor 1 (IGF1) and leptin
ea0008dp20
ELECTRON BEAM CT MEASUREMENT OF CORONARY ARTERY CALCIUM ALLOWS INDIVIDUAL RISK ASSESSMENT OF CHD IN UK DIABETIC PATIENTS
ea0008dp21
Euglycaemic Diabetic ketoacidosis in pregnancy
ea0008dp22
FAILURE OF SUPPRESSION OF ENDOGENOUS GLUCOSE PRODUCTION (EGP) DIMINISHED LIPOLYSIS AND FREE FATTY ACID (FFA) OXIDATION IN A POPULATION AT HIGH RISK FOR THE DEVELOPMENT OF TYPE 2 DIABETES
ea0008dp23
Inducing weight loss with steroids: a case of neurosarcoidosis
ea0008dp24
Growth Factors Strand
(1)
Growth factors and stem cell research
ea0008gs1
Imaging tissue repair: Molecular imaging techniques and their role in the characterisation of tissue repair processes
ea0008gs2
Wound healing studies in mice and flies
ea0008gs3
Haematopoietic Stem Cells: What Regulates the Regulator?
ea0008gs4
Biology and Therapeutic Potential of Neural Stem Cells
ea0008gs5
Directing cells to become muscle
ea0008gs6
Oral Communications (1)
(1)
Exploiting Phage Technology for Targeting Gene Delivery into the CNS
ea0008go1
siRNA-Mediated Knock Down of NgR, p75NTR and Rho-A Disinhibits Neurotrophin-Induced Dorsal Root Ganglia Neurite Outgrowth on CNS Myelin
ea0008go2
VEGF secretion from pituitary folliculo-stellate cells: a role for KATP channels?
ea0008go3
IGF-independent acceleration of myogenesis by IGFBP-5: modulation of cell survival and differentiation signalling pathways
ea0008go4
Evidence for a role of the Type 1 IGF receptor in early follicular development in cultured human ovarian tissue
ea0008go5
THE INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN-5 (IGFBP-5) PROFILE IN PRIMARY CULTURES OF DIFFERENTIATED MOUSE MAMMARY EPITHELIAL CELLS
ea0008go6
Modulation of the circulating insulin-like growth factor system in patients with gastrointestinal inflammation
ea0008go7
Intermittent recombinant growth hormone (Saizen) treatment in short children born small for gestational age: Results of two different treatment regimens on growth parameters after 4 years
ea0008go8