Searchable abstracts of presentations at key conferences in endocrinology
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195th Meeting of the Society for Endocrinology joint with Diabetes UK and the Growth Factor Group

Poster Presentations

Endocrine Tumours and Neoplasia

ea0008p44 | Endocrine Tumours and Neoplasia | SFE2004

Expression of Bone Morphogenetic Protein receptors in human pituitary adenomas

Brown PL , Stoddart HL , Sidhu KK , Milligan TP , Burrin JM

Bone morphogenetic proteins (BMPs) regulate growth, differentiation and apoptosis in a variety of tissues and have crucial roles in the regulation of reproduction. BMPs bind specific Type II receptors and form complexes with Type I receptors (Alk2, 3 or 6) whereby the Type II receptors activate Type I receptors by phosphorylation. BMP2 and 4 play a crucial role in the development of the gonadotroph cell lineage during mouse pituitary morphogenesis and BMP6, 7, and 15 stimulate...

ea0008p45 | Endocrine Tumours and Neoplasia | SFE2004

Diagnosis of a gastrinoma in patients on proton pump inhibitor therapy

Lewis CJ , Dhillo WS , Meeran K , Todd JF

BACKGROUND: Patients with dyspepsia are treated with proton pump inhibitors (PPIs) which reduce acid secretion and therefore give rise to a secondary hypergastrinaemia. Gastrinomas are a rare cause of dyspepsia diagnosed on the basis of a raised fasting gastrin measurement. Therefore, when screening patients with dyspepsia for a gastrinoma, PPIs must be withdrawn for 2 weeks, prior to the measurement of fasting gastrin levels to ensure that fasting gastrin levels are back to b...

ea0008p46 | Endocrine Tumours and Neoplasia | SFE2004

Fractionated urinary metanephrines and the diagnosis of phaeochromocytoma

Perry CG , Sawka A , Singh R , Bajnarek J , Ericksson D , Young|#Jr WF

Background: Phaeochromocytomas (PC) are rare tumours of chromaffin cells which may present with relatively common and non-specific symptomatology. The optimal biochemical investigation to confirm or refute the diagnosis remains unclear; some centres use fractionated plasma metanephrines, which are very sensitive but lack specificity, while others use conventional measurements of urinary metanephrines, which may be affected by concurrent drug administration and are less sensiti...

ea0008p47 | Endocrine Tumours and Neoplasia | SFE2004

Elevated FP receptor signalling in endometrial adenocarcinoma cells promotes expression of inflammatory and angiogenic genes via the EGFR and ERK1/2 pathways

List T , Boddy SC , Sales KJ , Jabbour HN

Prostaglandin F2a (PGF) is biosynthesised by cyclooxygenase (COX) enzymes and mediates its activity following FP receptor activation. Recently, we have shown elevated FP receptor expression and signalling in endometrial adenocarcinomas. This study investigated FP receptor signalling in human endometrial adenocarcinoma (Ishikawa) cells.Ishikawa cells were stably transfected with FP receptor cDNA in the sense (FPS) and antisense (FPAS) orientati...

ea0008p48 | Endocrine Tumours and Neoplasia | SFE2004

An audit of long-acting Somatostatin receptor ligand therapy in acromegaly

Curran SE , Holmes C , Webb A , Gurnell M , Chatterjee VKK

Whilst surgery and external beam radiotherapy remain cornerstones of the management of acromegaly, recent guidelines have emphasised the importance of adjunctive medical therapy [e.g. with somatostatin receptor ligands (SRLs), dopamine agonists, growth hormone (GH) receptor antagonists] in attaining 'safe' GH and insulin like growth factor 1 (IGF-1) levels, especially in patients who are not 'cured' following primary intervention. Several studies have established the efficacy ...

ea0008p49 | Endocrine Tumours and Neoplasia | SFE2004

HISTOPATHOLOGICAL SURPRISE IN A RADIOLOGICALLY PATIENT OF ACROMEGALY: SOMATOROPINOMA WITH NEURONAL CHORISTOMA

Dutta PD , Bhansali AB , Dradotra B , Singh P

Case report;A 42-year-old male presented with headache, coarserning of facial features, enlargement of body parts of 2 years duration. There was no visual disturbance. His height was 168cms, wt 71kg and BMI of 25Kg/ per met square.He was normotensive .Biochemical and hormonal profile revealed he was euglycemic, euthyroid, serum cortisol(am)280nmo/lit(normal 450-700nmo/lit) non suprresible GH values of 46 ng/ml with 75gms of oral glucose (normal< 1 ng ...

ea0008p50 | Endocrine Tumours and Neoplasia | SFE2004

Dramatic response with medical treatment of an extensively invasive 'giant' prolactinoma with cabergoline

Muralidhara KS , Ahmed A , Darko D

A previously well 75 year old man, presented with progressive right sided weakness and ataxia of three months duration that had worsened considerably during the previous 3 weeks. On examination, there was right hemiparesis, marked ataxia, sluggish pupillary responses and an extensive right sided visual field deficit confirmed by formal visual field testing. CT brain large suprasellar mass extending into pituitary fossa. MRI brain confirmed it to be a large pituitary macroadeno...

ea0008p51 | Endocrine Tumours and Neoplasia | SFE2004

Prognostic value Carcinoembryonic antigen (CEA)of in patients with the familial medullary thyroid carcinoma (FMTC)

Pulatova NR , Ismailov SI

Today calcitonin (CT) and carcinoembryonic antigen (CEA) are widely used as markers of medullary thyroid carcinoma (MTC). Postoperative CT and CEA normalization is a favorable prognostic factor. The work was initiated to assess CEA diagnostic and prognostic value before and after surgery in patients with familial medullary thyroid carcinoma (FMTC). Methods: blood serum from 11 patients with FMTC (mean age 27.4 plus/minus 3.2) undergoing total thyroidectomy and lymph node disse...

ea0008p52 | Endocrine Tumours and Neoplasia | SFE2004

Multiple hepatic embolisations are an effective treatment for metastatic gastrinoma

Martin NM , Morganstein DL , Higham CE , Jackson J , Todd JF , Meeran K

A 55 year old lady presented to our hospital in 1991 with a year's history of diarrhoea, weight loss and abdominal pain. On examination, she had 5cm hepatomegaly. Serum gastrin was elevated (148 pmol per litre NR < 40), as was GAWK (276 pmol per litre NR < 150). Basal gastric acid secretion was increased (39 mmol per hour NR < 5). CT abdomen showed multiple hepatic metastases, confirmed to be neuroendocrine in origin on biopsy. There were no clinical or biochemical fe...