Searchable abstracts of presentations at key conferences in endocrinology
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195th Meeting of the Society for Endocrinology joint with Diabetes UK and the Growth Factor Group

Poster Presentations

Growth and development

ea0008p53 | Growth and development | SFE2004

An inducible gene expression model and expression microarray to determine regulators of human pancreatic beta cell differentiation

Dunleavey L , Piper K , Custard E , Worley H , Packham GK , Wilson DI , Hanley NA

Understanding human pancreatic beta cell differentiation provides safe, normal pathways by which to manipulate stem cells for the ambitious treatment of Type 1 diabetes (1-3). The transcription factor Neurogenin 3 (Ngn3) is a transient, yet critical regulator of this process, committing progenitor cells to an endocrine cell fate (4). However, the downstream consequences of NGN3 expression remain incompletely understood.To identify new target genes of NGN...

ea0008p54 | Growth and development | SFE2004

Early development and subsequent metabolic parameters in Holstein-Friesian Dairy Cows

Swali A , Taylor VJ , Beever DE , Wathes DC

Dairy cows normally calve for the first time when not yet fully grown. Subsequent pregnancies occur during lactation. Therefore in primiparous (PP) cows the fetus competes for nutrients with maternal growth, while in multiparous (MP) cows they compete with milk production. Human epidemiological studies demonstrate that low birth weight can predispose offspring to a variety of metabolic diseases in adult life. This study investigated the hypothesis that such competition limits ...

ea0008p55 | Growth and development | SFE2004

Intermittent recombinant growth hormone (Saizen) treatment in short children born small for gestational age: Results of two different treatment regimens on growth parameters after 4 years

Simon D , Fjellestad-Paulsen A , Crabbe R , Czernichow P

While a number of studies have shown that treatment of children born small for gestational age (SGA) with continuously administered growth hormone (GH) induces a significant height improvement, this clinical trial approved by the local ethics committee investigated in a prospective way the growth response to different intermittent recombinant human GH (r-hGH, Saizen) treatment regimens over 4 years.Fifty-eight severely short (height standard deviation sc...

ea0008p56 | Growth and development | SFE2004

The effect of thyroid hormone (T3) and a beta-adrenoceptor agonist on uncoupling protein 3 (UCP3) mRNA expression in porcine adipose tissue (AT)

Bos PM , Litten JC , Perkins KS , Laws J , Symonds ME , Mostyn A , Clarke L

There are many theories regarding the function of UCP3, including transportation of fatty acids out of the mitochondria and production of reactive oxygen species. The function of UCP3 may influence the development of obesity and diabetes mellitus. In rodents UCP3 mRNA levels increase after T(sub)3(/sub) treatment. The ancient Meishan breed has enhanced neonatal survival rates than lean commercial breeds (C). Previous studies have demonstrated that plasma T(sub)3(/sub) is lower...

ea0008p57 | Growth and development | SFE2004

The influence of environmental temperature and hormonal manipulation on adipose tissue (AT) uncoupling protein (UCP) 3 expression in neonatal pigs

Elmes M , Litten JC , Perkins KS , Laws J , Symonds ME , Mostyn A , Clarke L

It is well established that the reduced neonatal mortality in Meishan, compared to commercial piglets, is due to resistance to hypothermia and hypoglycaemia. Underlying factors responsible for the differences in survival may include the disparity in plasma tri-iodothyronine (T3) concentrations and UCP expression (Mostyn et al (2004) Journal of Endocrinology, in press). ZD7114 (ZD), a synthetic beta3-adrenoceptor agonist, has been shown to improve thermogenesis in la...

ea0008p58 | Growth and development | SFE2004

11β hydroxysteroid dehydrogenase type 2 (11βHSD2) is expressed in omental fat of week old lambs

Davies D , Symonds ME , Gardner D

11β hydroxysteroid dehydrogenase (11βHSD) type 2 inactivates cortisol and has not been previously found in ovine or human adipose tissue (1,2). Early-mid nutrient restriction (NR) increases adipose tissue stores in term offspring and upregulates 11βHSD1 mRNA expression in perirenal adipose tissue. We determined the presence of 11βHSD2 mRNA expression in omental adipose tissue of neonatal lambs after early-mid maternal NR.19 twin-beari...

ea0008p59 | Growth and development | SFE2004

Is the Bone Mineral Density of Adults with GH Deficiency and GH-Insufficiency Truly Reduced?

Murray RD , Adams JE , Shalet SM

Limited data exist describing direct volumetric measures of BMD (g/cm3) in adults with severe GHD or GH-insufficiency. We measured BMD in 30 GHD adults (peak GH to stimulation <3 mcg/l), 24 GH-insufficient adults (GHI, pGH 3 - 7 mcg/l), and 30 age/gender matched control subjects by DXA and pQCT.DXA performed at the lumbar spine, femoral neck, and total hip confirmed GHD adults to have reduced BMD (g/cm2) at all sites (p = 0.05, p...

ea0008p60 | Growth and development | SFE2004

Urokinase-type plasminogen activator: a novel ligand for anosmin-1, the protein implicated in X-linked Kallmann's syndrome

#Youli|#Hu|# , #David|#Gonzalez-Martinez|# , #Soo-Hyun|#Kim|# , #Pierre|#Bouloux|#

Introduction: Loss of anosmin-1 function underlies the pathogenesis of X-linked Kallmann's syndrome (X-KS), a disorder characterized by anosmia (loss of smell) and hypogonadotrophic hypogonadism, due to olfactory bulb (OB) dysgenesis and failed migration of gonadotrophin releasing hormone (GnRH) neurons. Additional phenotypic features include bimanual synkinesis and unilateral renal agenesis. Anosmin-1 contains a whey acidic protein-like (WAP) domain and four contiguous fibron...