Searchable abstracts of presentations at key conferences in endocrinology
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195th Meeting of the Society for Endocrinology joint with Diabetes UK and the Growth Factor Group

ea0008p1 | Bone | SFE2004

The Effect of BsmI and FokI Genotypes on Bone Density and Bone Turnover Response to Raloxifene Therapy

Rogers A , Clowes JA , Gossiel F , Peel N , Eastell R

The vitamin D receptor (VDR) polymorphism, BsmI, has previously been associated with the efficacy of raloxifene therapy. The aim of this study was to examine associations between the BsmI and FokI polymorphisms of the VDR gene and bone density and bone turnover response to raloxifene. One hundred osteopenic postmenopausal women (ages 52 to 80 years, mean 64 years) were prescribed raloxifene (60mg/day) and calcium carbonate (500mg/day) for 48 weeks. Bone density at the lumbar s...

ea0008p2 | Bone | SFE2004

Serum 25 (OH) D and Dietary Calcium Intake are Associated with Bone Mineral Density Acquisition during Puberty

Bekheirnia MR , Shamshirsaz AA , Kamgar M , Erfanzadeh G , Aghili N , Shamshirsaz AmA

Objectives: This study aimed at determining the age of PBM and the age-specific relationships between calcium intake or serum 25(OH) D and bone mineral density (BMD) in Iranian adolescents.Design and Methods: A group of 187 healthy individuals of age 10-20 years was recruited. Using dual x-ray absorptiometry, areal BMD at femoral neck (aNBMD) and lumbar vertebrae (L2-L4) (aLBMD) were measured. Bone mineral apparent (volumetric) density (gram per cm ...

ea0008p3 | Bone | SFE2004

Depot Medroxyprogesterone Acetate Use is Associated with a Bone Density Deficit in Young Adult Women

Walsh JS , Eastell R , Peel NF

Previous studies of the injectable contraceptive depot medroxyprogesterone acetate (DMPA, Depo-Provera) and bone mineral density have produced differing results; a bone mineral deficit has been demonstrated in studies of the lumbar spine and hip, but not in studies of the forearm. In addition, DMPA users are likely to be smokers, pregnant at a young age, and not educated beyond high school level, which could contribute to the observed bone density deficit.<p class="abstext...

ea0008p4 | Bone | SFE2004

Poor Health May Predict Vertebral Fractures but Not Non-vertebral Fractures

Finigan J , Greenfield DM , Peel NFA , Blumsohn A , Hannon RA , Eastell R

Many risk factors predict fractures overall, but other factors may be associated with the incidence of vertebral fractures in particular. We carried out a 10-year prospective study of a population-based group of women, ages 50 to 85 years. At baseline we measured bone mineral density (BMD) and collected fasting blood samples for biochemical measurements including serum calcium, alkaline phosphatase, parathyroid hormone, creatinine, phosphate, albumin and thyroid hormones. Medi...

ea0008p5 | Bone | SFE2004

The effects of Simvastatin on the human osteoblast-like cell, SaOS-2

Abdulkhaliq A , Mancini L , Girgis SI

Background: Statins are widely prescribed cholesterol-lowering drugs. They inhibit cholesterol synthesis through inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase. They have also been recently identified as bone stimulatory agents (Mundy et al., 1999). They have been found to increase the expression of BMP-2 that triggers a cascade of events leading to increased bone formation. However, the exact mechanism for the stimulatory action of statins is not fully elucidat...