Endocrine Abstracts

With the success of statins in lowering LDL cholesterol and reducing cardiovascular disease (CVD) event rate, interest is shifting towards HDL cholesterol (HDL-C) as a potential target for therapeutic intervention.High HDL-C is associated with low CVD event rate. Reverse cholesterol transport may contribute to this association, and describes transfer of cholesterol on HDL particles from peripheral tissues to the liver. The transport process involves: ATP...

The process of sexual differentiation has been defined by examining animal models and human conditions where errors of sexual development result in ambiguous genitalia. The study of transsexualism where the cognitive sexual phenotype is not concordant with the individual's physical and genetic phenotype has also been important.The sex determining region of the Y chromosome controls male gonadal development by inducing SOX 9 which causes testicular differ...