Searchable abstracts of presentations at key conferences in endocrinology

ea0024op1.1 | (1) | BSPED2010

Insulin pump therapy in children with type 1 diabetes and its effect on growth and metabolism: 4 years experience

Babiker Amir , Datta Vipan

Background: Pump has become increasingly more popular amongst clinicians in the management of children with type 1 diabetes (T1DM). It improves the metabolic control in most patients though it may have a negative effect on growth. Eighty children with T1DM at our institute are currently treated with continuous subcutaneous insulin infusion (CSII) to achieve optimum glycaemic control.Aims: To identify the effect of CSII on hospital admissions, hypoglycaem...

ea0023oc5.5 | Oral Communications 5 | BSPED2009

Point of care blood ketone level: a useful tool to diagnose DKA?

Nath Puneet , Babiker Amir , Datta Vipan

Background: ISPAD clinical practice consensus guidelines 2006–7 defined DKA as: blood glucose >11 mmol/l in presence of venous pH <7.3 or bicarbonate <15 mmol/l, ketonaemia and ketonuria. The level of ketonaemia or ketonuria was not specified. Blood ketones can be checked easily using a blood ketone meter (Optium). In our institution we have been measuring them on all children admitted with suspected DKA over the last 5 years. A blood ketone level of >3.0 ...

ea0023p1 | (1) | BSPED2009

Lipoatrophy with insulin analogues in four children with type 1 diabetes

Babiker Amir , Thalange Nandu , Datta Vipan

Introduction: Lipoatrophy (LA) was common before the advent of recombinant human insulin. More recently, insulin analogues have been widely introduced into paediatric practice. In the literature, LA has only been reported so far with insulin Lispro (Lily, USA) (n=4 adult patients and 3 children) and insulin Glargine (Sanofi-Aventis, France) (n=1 adult patient). To our knowledge; this is the first report of LA with insulin Aspart (NovoRapid), biphasic insulin Aspa...

ea0023p38 | (1) | BSPED2009

Management of central diabetes insipidus in a paediatric intensive care unit

Babiker Amir , Acerini Carlo , Tasker Robert

Background: Central diabetes insipidus (CDI) is rare in infants and children. Up to 30 percent of cases are idiopathic and its clinical presentation is poorly defined. In critically ill paediatric intensive care unit (PICU) patient with CDI, there is increased risk of brain damage and death due to severe hyperosmolarity, hypovolaemic shock, hypernatraemic seizures or complications of treatment.Aim: To assess the causes, management and outcome of CDI in p...

ea0045oc6.4 | Oral Communications 6- Endocrine | BSPED2016

Impact of intercurrent illness on calcium homeostasis and hypoparathyroidism management

Chinoy Amish , Mughal Zulf , Skae Mars , Babiker Amir , Padidela Raja

Introduction: Hypoparathyroidism is typically managed with calcitriol/alfacalcidol. Close monitoring of serum calcium is required as under-treatment causes symptomatic hypocalcaemia while over-treatment will cause nephrocalcinosis. We report three cases who demonstrated resistance to treatment during an intercurrent illness, necessitating increase in medication doses and monitoring.Case series: Case 1: Two-month-old boy with newly diagnosed hypo...

ea0038oc5.5 | Thyroid and parathyroid | SFEBES2015

Investigating the genetic architecture of gland-in-situ congenital hypothyroidism by comprehensive screening of eight known causative genes

Nicholas Adeline K , Serra Eva Goncalves , Cangul Hakan , Al-Yaarubi Saif , Ullah Irfan , Habeb Abdelhadi , Deeb Asma , Peters Catherine , Dattani Mehul , Shenoy Savitha , Murray P G , Puthi Vijith , Park Soo-Mi , Nathwani Nisha , Babiker Amir , Martin Howard , Anderson Carl A , Maher Eamonn , Chatterjee V Krishna , Schoenmakers Nadia

Background: Lower cut-offs in TSH screening have doubled the incidence of congenital hypothyroidism (CH), particularly cases with an eutopically-located Gland-in-situ (GIS). Although mutations in known dyshormonogenesis genes, or the thyrotropin-stimulating hormone receptor (TSHR) may underlie such cases, these genes have not previously been screened comprehensively in a GIS CH cohort.Study design: We evaluated the relative contribution and mole...