Endocrine Abstracts

Introduction: Trimethylaminuria or Fish Odour syndrome is a rare genetic metabolic disorder. It can cause significant suffering to affected individuals due to social isolation and stigma. It is under recognised and ignored.The case: A 60 years old lady was referred by her GP. The referral – ‘She feels she has a problem with personal hygiene and is aware of an odour from her skin, her breath and urine.’ This lady has been suffering from thi...

Introduction: Lymphocytic Hypophysitis (LH) is an autoimmune endocrinopathy characterised by extensive infiltration of the anterior pituitary gland with chronic inflammatory cells, thus causing pituitary expansion and a variable degree of hypopituitarism closely mimicking the features noted in pituitary adenoma and seen most frequently in women. The aetiology has a general preponderance of occurring at the end of gestation or during the early postpartum period.<p class="ab...

We present a rare case of a 50 years old lady who presented with new onset hirsutism and hoarseness of voice since 2 years. Investigations showed high serum testosterone, androstendione and free androgen index. All other systemic and endocrinology evaluation for hirsutism did not reveal any abnormality. CT scan of her abdomen showed a right ovarian mass which was confirmed as a Sertoli-Leydig cell tumour (stage Ia) on surgical staging and completely cured after bilateral salpi...

We present the case of a 50-year-old lady who initially presented to the endocrine department at Royal Bolton Hospital in 2011 with symptoms of tiredness and lethargy following hysterectomy and bilateral salpingo-oophorectomy in 2003. Hormone replacement therapy was not commenced in view of a strong family history of breast cancer. There is a family history of both autoimmune hypothyroidism and hyperthyroidism. Thyroid function tests were normal, with a positive thyroid peroxi...

Introduction: Ectopic ACTH syndrome (EAS) is associated with small cell carcinoma of the lung. It is reported as a rare condition. Here we report three cases of undiagnosed bronchogenic carcinoma who presented with EAS within a period of 12 months.Case 167-year-old lady, smoker, presented with severe proximal myopathy of 4 week duration. Clinically she appeared cushingoid. Newly diagnosed Type two diabetes. Lab tests – potassi...

Background: Radioiodine therapy using I131 is a well established, safe, cheap and effective treatment for thyrotoxicosis. Current recommendations support the administration of 400-550 Mbq. At this centre, we use a dose of 550 Mbq with the aim of minimising the chance of the patient remaining thyrotoxic following therapy.Aims: To determine (a) the thyroid status of patients following treatment with I131 at a dose of 550 Mbq, (b) the ...

Introduction: Deranged thyroid function tests are frequently referred to the endocrine team and are generally secondary to the assay interference.Case report: We Report a case of 33 years old lady referred with symptoms of dizziness, palpitations, cold intolerance and poor sleep with no associated tremors or weight changes. No goiter was observed on clinical examination. Thyroid function test showed abnormal hormone leve...

Milk Alkali syndrome (MAS), a rare cause of hypercalcaemia, is reversible and caused by the ingestion of large amounts of calcium (Ca) and absorbable alkali. We report a case of MAS in a 37 year old female, admitted with Ca of 3.44 (2.15–2.62 nmol/l). Presenting complaints include 6 months history of worsening fatigue, thirst, polyuria, abdominal pain and a complex background of bipolar disorder, fibromyalgia, spina bifida, lumbar spine fusion and extremely limited mobili...

Introduction: Vitamin D deficiency is common in ethnic minority population living in UK. It is a relatively easily treatable condition. However, if left untreated it may lead to chronic secondary hyperparathyroidism and onto tertiary hyperparathyroidism. We report three cases of severe vitamin D deficiency who presented with hypercalcaemia.CasesWe report three patients. 60 and 46 years old ladies, both of south-asian origin, a 46 y...

Introduction: Thyroid nodules have a prevalence of 50% in the adult population in the UK. The risk of cancer is significantly lower if the nodules are a part of multi-nodular goitre. Fine needle aspiration and cytology (FNAC) is an important tool to assess the risk of malignancy in thyroid nodules.Method: We audited the safety and efficacy of management of thyroid nodules at Bolton in accordance with British Thyroid Association and Royal College of Patho...