Searchable abstracts of presentations at key conferences in endocrinology
Previous issue | Volume 38 | SFEBES2015 | Next issue

Society for Endocrinology BES 2015

Edinburgh, UK
02 Nov 2015 - 04 Nov 2015

Card image cap
2-4 November 2015, Edinburgh, UK Further information

Poster Presentations

Obesity, diabetes, metabolism and cardiovascular

ea0038p182 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Testing causality in the association of plasma cortisol with risk of coronary heart disease: a Mendelian randomisation study

Crawford Andrew , Timpson Nicholas , Davey Smith George , Walker Brian

Background: Elevated morning plasma cortisol is associated with multiple cardiovascular risk factors in metabolic syndrome. Epidemiological studies have also reported a positive association between plasma cortisol and coronary heart disease (CHD), although not all estimates are statistically significant (OR 1.10 (95% CI 0.97 to 1.25)) (Davey Smith et al. Circulation 2005). Importantly, observational studies are unable to infer causality and results may be confounded.<...

ea0038p183 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Gender-related differences in circulating microparticles characteristics: implications for cardiovascular risk?

Witczak Justyna , Rees Aled , James Philip

Introduction: Microparticles (MP) are circulating submicron particles released from cell membranes. They have an important role in intercellular endocrine signalling and may be increased in numerous conditions including cardiovascular disease. However, the influences of gender on MP characteristics are not fully understood.Aim: To compare MP characteristics (size, concentration, cellular origin and inflammatory profile) in healthy males and females acros...

ea0038p184 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Longer duration of sitting down in pregnancy is associated with gestational diabetes, greater weight gain and depressive symptoms

Sukumar Nithya , Farmer Jacqueline , Venkataraman Hema , Saravanan Ponnusamy

Background: Studies have shown that interruptions in sedentary time in non-pregnant adults is positively associated with metabolic parameters, including abdominal obesity and glucose tolerance. However, there are no specific guidelines in the UK about recommended physical activity for pregnant women nor any validated tools to measure it. Our aim was to determine how much physical activity is carried out by pregnant women and how it relates to body anthropometry, glucose tolera...

ea0038p185 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Transcriptome profiles of human pancreatic islets following transient ischemia identify inflammatory and cell death responses

Kelly Amy , Smith Kate , McCarthy Fiona , Smith Breonna , Badarinarayana Vasudeo , Steyn Leah , Strop Peter , Limesand Sean , Papas Klearchos

Islet transplantation, an effective treatment for Type I Diabetes, is compromised by transient ischemia. Ischemia reduces the viability and function of transplanted islets and may also promote signals that lower islet efficacy. In order to characterize the response of human islets to transient ischemia, high-throughput sequencing was employed to determine global gene expression. Islets isolated from healthy donors (n=4) were either pelleted in microcentrifuge tubes (i...

ea0038p186 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Studies of Nuf mice with an activating calcium-sensing receptor (CaSR) mutation demonstrate the CaSR to regulate pancreatic beta-cell mass and glucose homeostasis

Babinsky Valerie N , Hannan Fadil M , Nesbit M Andrew , Hough Alison , Stewart Michelle , Joynson Elizabeth , Hough Tertius A , Bentley Liz , Aggarwal Abhishek , Kallay Eniko , Wells Sara , Cox Roger D , Richards Duncan , Thakker Rajesh V

The modulation of pancreatic islet mass represents a novel therapeutic approach for the management of diabetes mellitus. G-protein coupled receptors (GPCRs) regulate beta-cell expansion and proliferation, and the objective of this study was to assess whether the calcium-sensing receptor (CaSR), which is an abundantly expressed beta-cell GPCR, may influence islet mass and systemic glucose homeostasis, and thus represent an exploitable drug target in some forms of diabetes. We c...

ea0038p187 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Role of oral cholecalciferol as adjuvant therapy in type 1 diabetes mellitus: randomised controlled trial

Sharma Shreya , Biswal Niranjan , R Medha , Kamalanathan Sadish Kumar , B Adhisivam

Introduction: The vitamin D hormone system has been implicated in the pathogenesis of several autoimmune diseases, including Type 1 Diabetes Mellitus, as an adaptive immune system modulator.Objectives: The objective of this study is to examine the role of cholecalciferol in modulating the altered immune response in T1DM, thereby improving glycemic control and residual pancreatic Beta-cell function, measured objectively by Haemoglobin A1c levels, GAD65 an...

ea0038p188 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Prevalence and determinants of metabolic syndrome among HIV infected patients receiving highly active antiretroviral therapy in Kano, northwestern Nigeria

Muhammad Fakhraddeen , Mukhtar Rahila , Adenike Enikuomehin , Muhammad Fauziyyah , Gezawa Ibrahim

Background: We aimed to determine and compare the prevalence and associated factors of metabolic syndrome (MS) among HAART exposed versus HAART naïve HIV infected patients at the Aminu Kano Teaching Hospital, Kano (AKTH).Method: In this cross-sectional comparative study we evaluated 300 HIV infected persons who were divided into two age and sex matched groups – HAART-exposed and HAART-naïve – attending AKTH. MS was diagnosed using ATP...

ea0038p189 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

The effect of L-arginine on anorectic gut hormone release in humans

Amin Anjali , Neophytou Christina , Murphy Kevin

High protein diets suppress appetite and facilitate weight loss, but are difficult to adhere to in the long-term. Understanding the mechanisms by which protein suppresses appetite may establish targets for more acceptable interventions to treat or prevent obesity. Of particular interest is the concept of functional foods or novel products which aim to potentiate satiety. However, the specific mechanisms regulating protein-induced satiety are unknown. Protein has a satiating ef...

ea0038p190 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Generation of a long acting GCSF for treatment of neutropenia and stem cell harvest

Alshehri Abdulrahman

Rationale: Over the last 20 years, granulocyte colony-stimulating factor (GCSF) has become a recognised therapy in the treatment of patients suffering from neutropenia. Current therapies require daily injections of GCSF to stimulate stem cell production and response to treatment is often unpredictable as GCSF is rapidly cleared. A number of approaches to reducing GCSF clearance have been tried mainly through conjugation with another moiety. The technologies already being emplo...

ea0038p191 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Hypercortisolaemia increases femoral adipose tissue blood flow but not net fatty acid release in vivo

Manolopoulos Konstantinos , Bujalska Iwona , Luzio Steve , Arlt Wiebke , Tomlinson Jeremy

Hypercortisolaemia (Cushing’s Syndrome) is characterised by abdominal fat accumulation and gluteofemoral fat loss. The mechanisms underpinning this fat mass redistribution are unknown. Adipose tissue blood flow (ATBF) and net fatty acid release rate (lipolysis) are important determinants of depot-specific fat mass. We hypothesized that hypercortisolaemia may result in increased femoral ATBF and lipolysis promoting gluteofemoral fat mass loss. We recruited nine healthy mal...

ea0038p192 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Central IL6 signalling and the development of impaired insulin secretion in type2 diabetes

Yiannakas Adonis , McNeilly Alison D , Gallagher Jennifer , Wright Kathryn , McCrimmmon Rory J

Obesity and the metabolic syndrome are chronic inflammatory states that are now understood to be involved in the development type 2 Diabetes. Hypothalamic cytokine signalling is thought to influence neuroendocrine networks critical to the dynamic maintenance of glucose homeostasis. Interleukin 6 (IL6) is a cytokine that displays tissue-specificity and is instrumental in the mounting of the acute phase response, as well as in the subsequent resolving and adaptive phase. IL6 is ...

ea0038p193 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Women with idiopathic intracranial hypertension have a distinct andro-metabolic signature compared to polycystic ovary syndrome and simple obesity

O'Reilly Michael , Kempegowda Punith , Botfield Hannah , Ali Fizzah , Taylor Angela , Hughes Beverley , Tomlinson Jeremy , Arlt Wiebke , Sinclair Alex

Context: Idiopathic intracranial hypertension (IIH) is characterised by elevated intracranial pressure and occurs predominantly in obese premenopausal women. Signs and symptoms of polycystic ovary syndrome (PCOS) often coexist in IIH. Here we compared the androgenic and metabolic phenotypes in IIH, PCOS and simple obesity.Patients and methods: We studied 25 patients with IIH (mean age 34.4±9.2 years; mean BMI 37.8±5.2 kg/m2), in comp...

ea0038p194 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Differences between men and women in markers of dietary fatty acid oxidation

McNeil Catriona , Pramfalk Camilla , Pavlides Michael , Karpe Fredrik , Hodson Leanne

Men have a higher prevalence and risk of non-alcoholic fatty liver disease (NAFLD) than age-matched women and this may, in part, be related to differences in fatty acid oxidation. Fasting and postprandial fatty acid oxidation was investigated in 11 healthy men and 11 healthy women matched for age (46±2 years vs 46±2 years (mean±S.E.M.)), BMI (28.0±1 vs 27.0±1 kg/m2) and liver fat content (3.4±0.9 vs 3.9±0.7%) measure...

ea0038p195 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Establishing human liver cell models to investigate the effects of exogenous metabolic substrates on fatty acid partitioning

Green Charlotte , McNeil Catriona , Morten Karl , Hodson Leanne

Hepatic steatosis, accumulation of intracellular triglyceride (TG) (>5% of hepatic tissue), is the prerequisite for the development of non-alcoholic fatty liver disease (NAFLD). NAFLD represents a spectrum of liver diseases and is associated with obesity and obesity-related metabolic diseases such as type 2 diabetes and cardiovascular disease. Steatosis occurs due to an imbalance between fatty acid input and removal (fatty acid partitioning) which can be affected by geneti...

ea0038p196 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Evidence for 11β-HSD1 regulation of brain energy metabolism following systemic inflammation

Verma Manu , Kipari Tiina , Seckl Jonathan , Holmes Megan , Chapman Karen

Background: Chronically elevated brain glucocorticoid (GC) levels impair cognition. In rodents, raised GC levels prior to lipopolyaccharide (LPS) administration potentiate neuroinflammation although GC suppresses neuroinflammation if administered after LPS. 11β-hydroxysteroid dehydrogenase-1 (11β-HSD1) activity can increase intracellular GC levels, including in the brain, without alteration in circulating levels. 11β-HSD1 deficiency/inhibition protects against a...

ea0038p197 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Impact of number of transplanted human islet equivalents on successful return to normoglycaemia in an NSG diabetic mouse model

Bond Andrew , Noble June , Casey John , Campbell John , Forbes Shareen

Introduction: Islet transplantation (ITx) is a therapeutic option for patients with Type 1 diabetes. However there is attrition of graft function and the majority of patients require exogenous insulin injections and/or further transplants, within five years. Mouse models help elucidate mechanisms of islet graft failure and the NOD/Lt-scid IL2rγnull (NSG) mouse is useful to study human islet engraftment but few published studies exist. As diffe...

ea0038p198 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Vascular dysfunction in horses with insulin resistance

Morgan Ruth , Keen John , Walker Brian , Hadoke Patrick

Background: Vascular impairment, most commonly due to endothelial dysfunction, is associated with cardiovascular risk in humans with obesity, insulin resistance or Cushing’s syndrome. Similar endocrine disorders in horses, resulting in insulin resistance, are associated with laminitis, a dysfunction of the vasculature supplying the hooves, the mechanism of which is unclear. We hypothesised that horses with insulin resistance have both local and systemic evidence of vascul...

ea0038p199 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Evidence for improved mitochondrial efficiency in adipose tissue of T2DM women after malabsorptive but not restrictive bariatric surgery

Martinez de la Escalera Lucia , Jackisch Laura , Kyrou Ioannis , Vrbikova Jana , Hainer Vojtech , Fried Martin , Sramkova Petra , Piya Milan , Kumar Sudhesh , Tripathi Gyanendra , McTernan Philip

Aims/hypothesis: Genetic and functional defects in mitochondria are linked with phenotypes of obesity, hypercholesterolemia, and type 2 diabetes (T2DM). However, the impact on mitochondria during surgery-induced metabolic recovery is unknown. We therefore studied the effect of restrictive versus malabsorptive bariatric procedures on indicators of mitochondrial efficiency and control of biogenesis/function.Methods: Forty-three morbidly obese, T2DM consent...

ea0038p200 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

AMPK activators modulate pro-inflammatory responses in human adipocytes

White Anna , Mancini Sarah , Nguyen Dinh Cat Aurelie , Montezano Augusto , Salt Ian , Touyz Rhian

Adipose tissue inflammation may be an important mechanism in the development of systemic insulin resistance, such that modulation of this system may be a therapeutic target for type 2 diabetes and obesity-related disorders. AMPK has anti-inflammatory properties, yet the anti-inflammatory actions of AMPK in adipocytes remain poorly characterised. We questioned whether AMPK activation influences pro-inflammatory responses in cultured adipocytes in basal and stimulated conditions...

ea0038p201 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

eNAMPT-monomer plays a critical role in pathophysiology of experimental diabetes and represents a novel target for treatment of type 2 diabetes

Kieswich Julius , Silvestre Marta , Harwood Steven , Yaqoob Muhammad , Caton Paul

Extra-cellular nicotinamide phosphoribosyltransferase (eNAMPT; also referred to as visfatin/PBEF) concentrations are elevated in serum of patients with type 2 diabetes (T2D). However, the relationship between abnormally elevated serum eNAMPT and the pathophysiology of T2D is unclear. eNAMPT circulates in functionally and structurally distinct monomer and dimer forms. eNAMPT-dimer exerts NAD-biosynthetic activity. The role of eNAMPT-monomer is unclear but may exert NAD-independ...

ea0038p202 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Predictors of glycaemic response and impact on weight and BP of dapagliflozin therapy in type 2 diabetes

Huang Feicong , McConnell Lyndsey , Sainsbury Christopher , Jones Gregory

Background: Dapagliflozin was the first SGLT2 inhibitor licensed in UK to improve glycaemic control in type 2 diabetes. The study aimed to assess impact of dapagliflozin on glucose, weight and BP and identify factors predictive of glycaemic response in a large cohort.Methods: Observational retrospective data collected on all patients prescribed dapagliflozin across primary and secondary care in two Scottish health board areas. HbA1c, weight, BP and conco...

ea0038p203 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Pre-operative assessment for Sleep apnoea in patients referred for bariatric surgery: the usefulness of various clinical screening tools

Martinou Chrysiis , Nayak Ullal , Varughese George , Thomas Ajit , Allen Martin , Varadhan Lakshminarayanan

Aim: Obstructive sleep apnoea (OSA) is widely prevalent in patients with obesity, referred for bariatric surgery. Various clinical tools are clinically used for screening pre-operatively before referring for formal sleep studies. The aim of our observational analysis was to assess the usefulness of various screening methods for OSA used in clinical practice.Methods: Records of all patients who had been referred to bariatric services in 2014 were reviewed...

ea0038p204 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Effect of vitamin D supplementation on cardiovascular risk factors and exercise performance in healthy subjects; a randomised placebo controlled pilot study

Munir Nimrah , Iniesta Raquel Revuelta , Al-Dujaili Emad A S

Background: Evidence suggests associations between vitamin D deficiency and cardiovascular risk factors, including hypertension and excessive cortisol levels. Also, vitamin D levels may be associated with exercise performance. Thus, we aimed to investigate the effects of vitamin D intake on cardiovascular risk factors, free urinary cortisol and exercise performance.Methods: A randomised placebo controlled single-blinded parallel trial was conducted in he...

ea0038p205 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Evaluation of adipocytokines and traditional cardiometabolic risk factors in young male cancer survivors: an age-matched control study

Greenfield Diana , Blewitt Alice , Coleman Robert , Walsh Jennifer , Snowden John , Ross Richard , Han Thang

Background: Life expectancy of cancer survivors has doubled in the past four decades; however, death due to cardiovascular disease is more prevalent in survivors than the general population.Objective, design and methods: We evaluated novel and traditional cardiometabolic risk factors in young male cancer survivors in a cross-sectional study of male cancer survivors aged 25–45 years compared with age-matched non-cancer controls. Demographic and anthr...

ea0038p206 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Low vitamin B12 in pregnancy is associated with maternal obesity and gestational diabetes

Sukumar Nithya , Wilson Sean , Venkataraman Hema , Saravanan Ponnusamy

Aims: Vitamin B12 insufficiency has been linked with adiposity and insulin resistance. A clinical study from India showed that B12 insufficiency in pregnancy was associated with higher risk of gestational diabetes (GDM), mediated by maternal BMI. It is not known whether the same association exists among pregnant women in the UK.Methods: A retrospective study was done on women attending our antenatal clinic from 2010–2013. Information including mater...

ea0038p207 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Adrenaline mediated metabolic and functional quiescence protects insulin producing cells from hypoxia

Kelly Amy , Smith Rachel , DiBase Samantha , Davenport Hailey , Limesand Sean

Pancreatic islets are susceptible to hypoxia during isolation, culture, and transplantation. An intervention that protects against hypoxia while preserving β-cell function will improve islet quality. Adrenaline suppresses insulin secretion and oxygen consumption in pancreatic islets. These findings suggest that adrenergic action creates metabolic quiescence in β-cells. Our objective was to determine whether adrenaline is protective during hypoxic culture in an insuli...

ea0038p208 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Bile acids stimulate GLP-1 release predominantly by accessing basolateral GPBAR1 (TGR5)

Brighton Cheryl A , Rievaj Juraj , Kuhre Rune E , Glass Leslie L , Holst Jens J , Gribble Fiona M , Reimann Frank

Background: Glucagon-like peptide 1 (GLP-1) is an incretin hormone released from enteroendocrine L-cells in the gut. GLP-1 analogues and dipeptidyl-peptidase-4 inhibitors are currently used to treat type-2 diabetes. A greater understanding of the mechanisms underlying the release of GLP-1 may facilitate the development of therapeutics to stimulate the release of endogenous GLP-1. Bile acids have been shown to induce GLP-1 release via the G protein-coupled bile acid receptor 1 ...

ea0038p209 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Vitamin B12 deficiency alters adipogenesis and associated microRNA’s in human adipocytes

Adaikalakoteswari Antonysunil , Vatish Manu , McTernan Philip , Randeva Harpal , Tripathi Gyanendra , Saravanan Ponnusamy

Background: Human cohorts and animal models provide compelling evidence suggesting the role of vitamin B12 in modulating the risk of diabetes and adiposity via developmental programming. We recently demonstrated that neonates born to mothers with low B12 levels in pregnancy have adverse cord blood lipid profile and in vitro studies in human adipocytes with low B12 showed increased cholesterol biosynthesis. Therefore, we hypothesized that vitamin B12 deficiency may pla...

ea0038p210 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Proteomic detection of extracellular matrix proteins in insulin-resistant skeletal muscle

Kang Li , Lin De , Sneddon Claire

Increased deposition of extracellular matrix (ECM) components such as collagens and hyaluronan is associated with diet-induced insulin resistance (IR) in skeletal muscle. Studies of the role of specific ECM components in muscle IR have been pivotal but incomplete. Here we used an approach (i.e. ECM-specific mass spectrometry-based proteomics) that gives a more complete view of ECM protein abundance with muscle IR. Male C57BL/6 mice were fed with either a chow or high fat (HF) ...

ea0038p211 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Longitudinal changes in adipose tissue gene expression profile are asociated with deteriorating glucose tolerance

Woods Conor , Crowley Rachel , Gathercole Laura , Hughes Beverly , Gray Joanna , McCarthy Theresa , Crabtree Nicola , Stewart Paul , Tomlinson Jeremy

Increased adiposity is associated with insulin resistance, type 2 diabetes and metabolic dysfunction. Altered adipokine secretion, changes in local and systemic glucocorticoid metabolism and increased inflammation have all been postulated as contributory mechanisms. We have previously described changes in subcutaneous adipose tissue (SAT) gene expression that are associated with obesity and glucose intolerance in cross-sectional studies. However, the effects of longitudinal ch...

ea0038p212 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Distinguishing different subtypes of aldosterone-producing adenoma by histological, immunohistochemical and radiological features; a basis for individualised treatment strategies in primary aldosteronism?

Powlson Andrew S , Teo Ada , Haris Lalarukh , Maniero Carmela , Marker Alison , Azizan Elena , Gurnell Mark , Brown Morris J

Background: Primary aldosteronism (PA) is now recognised to account for 5–10% of all cases of hypertension (and 20–25% of refractory hypertension). For patients with a demonstrable unilateral cause, adrenalectomy offers the potential for cure of PA, although resolution of hypertension occurs in only ~50% of patients. We have examined histological appearances and radiological features in patients with APAs undergoing adrenalectomy in an attempt to further our understa...

ea0038p213 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Adrenal insufficiency following bariatric surgery

Rajeswaran Chinnadorai , Oglesby Sarah , Zaidi Syed Zulfiqar Raza , Muniyappa Suresha

Introduction: Bariatric surgery is now a common surgical procedure for weight management recommended by NICE. Complications such as dumping syndrome, micronutrient deficiencies and cholelithiasis are well documented in the literature. Here we discuss the lesser reported complication of adrenal insufficiency seen in three patients following roux-en-y gastric bypass surgery for morbid obesity.Case reports: Three patients were seen in the outpatient clinic ...

ea0038p214 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Discovery and localisation of the expression of calcitonin-type and CRH-type neuropeptide precursors in an echinoderm

Cai Weigang , Egertova Michaela , Badi Yusef , Semmens Dean , Elphick Maurice

Calcitonin and corticotropin-releasing hormone (CRH) are members of a family of neuropeptides that exert effects by activating secretin-type G-protein coupled receptors. Calcitonin lowers blood calcium levels and acts to protect against calcium loss from the skeleton during periods of calcium mobilisation. CRH is a key player in the stress response mediated by the hypothalamic-pituitary-adrenal axis. Analysis of the phylogenetic distribution of calcitonin-type and CRH-type pep...

ea0038p215 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

The role of vitamin B12 deficiency in molecular mechanism of metformin

Khin May Oo , Antonysunil Adaikala , Kumsaiyai Warunee , Voyias Philip , Mcternan Philip , Gates Simon , Tripathi Gyanandra , Saravanan Ponnusamy

The anti-diabetic drug, metformin, is associated with progressive decrease in serum vitamin B12 levels whereas vitamin B12 deficiency is related to increased insulin resistance and dyslipidaemia by altered methylation. As the risk of vitamin B12 deficiency is increased among metformin users, it is of utmost importance to examine how metformin response in vitamin B12 deficient population.We investigated the cellular mechanism of metformin in vitamin B12 i...

ea0038p216 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Enhanced orbitofrontal cortex activation following sympathetic neural stimulation in young women with polycystic ovary syndrome: an fMRI study

Lansdown Andrew , Warnert Esther , Wise Richard , Rees Aled

Introduction: Polycystic ovary syndrome (PCOS) is associated with increased cardiovascular risk, which may relate to enhanced sympathetic nervous system (SNS) activation. The cerebral pathways involved in this process are not known.Aims: i) To compare SNS activation in response to isometric forearm contraction (IFC) in patients with PCOS and controls. ii) To identify and compare the neuronal signatures of this response.Methods: 15 ...

ea0038p217 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Enhanced insulin secretion and insulin action in young lambs with intrauterine growth restriction

Camacho Leticia , Limesand Sean

Intrauterine growth restriction (IUGR) is associated with postnatal metabolic complications, which include glucose intolerance in adulthood. However, information is limited on the progression of insulin secretion and its action in young IUGR infants. The objective of this study was to determine glucose stimulated insulin secretion and insulin action in young lambs with placenta insufficiency-induced IUGR.Placental insufficiency-induced IUGR was created b...

ea0038p218 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Glucocorticoid excess increases hypothalamic AgRP and results in obesity and hyperinsulinaemia in mice

Wray Jonathan , Harno Erika , Davies Alison , Sefton Charlotte , Ramamoorthy Thanuja Gali , Allen Tiffany-Jayne , Coll Anthony P , White Anne

Glucocorticoids (Gcs) are widely prescribed to treat a number of conditions, such as arthritis and asthma. However, patients receiving Gcs often develop metabolic complications such as obesity and hyperglycaemia. The aim of this study was to investigate the molecular mechanisms in the hypothalamus which drive these adverse effects. Male C57BL/6J mice were given ad libitum access to either corticosterone (CORT; 75 μg/ml) or vehicle (V; 1% ethanol) in their drinkin...

ea0038p219 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Non-selective beta-adrenergic agonist infusion acutely stimulates the temperature of brown adipose tissue in adult males

Scotney Hannah , Symonds Michael , Law James , Budge Helen , Sharkey Don , Manolopoulos Konstantinos

Brown adipose tissue (BAT) is present in small quantities in human adults (~100 g) and can have a significant influence on metabolism. This effect is mediated by rapid activation of the BAT specific uncoupling protein 1 (UCP1), following stimulation of β-adrenergic receptor (AR) by the sympathetic nervous system. AR agonists stimulate rodent BAT, but have so far provided inconsistent findings in humans when administered orally (Vosselman et al. 2012). Rapid activ...

ea0038p220 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Endogenous ARX knockdown enhances beta-cell lineage specification and maturation during ex vivo transdifferentiation of human exocrine pancreatic tissue

Lima Maria Joao , Docherty Hilary M , Muir Kenneth R , Forbes Shareen , Casey John , Docherty Kevin

The shortage of donor material has driven research towards finding a replenishable supply of islets for transplantation. We have previously shown that the exocrine material that results as a by-product of the islet isolation procedure can be transdifferentiated towards functional islet-like structures by overexpression of the pancreatic transcription factors (TFs) Pdx1, MafA, Ngn3 and Pax4 followed by culture in the presence of betacellulin, nicotinamide and exendin-4. These c...

ea0038p221 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Altered adipocytes in an ovine model of polycystic ovary syndrome

Siemienowicz Katarzyna , Couckan Flavien , Lerner Avi , Franks Steve , Rae Mick , Duncan Colin

Women with Polycystic Ovary Syndrome (PCOS) are at increased risk of developing insulin resistance, obesity and dyslipidemia, however obesity per se does not explain the higher incidence of insulin resistance in PCOS women when compared to the general population. Altered adipose tissue morphology and function may be a central factor contributing to metabolic disturbances in PCOS. Using a clinically realistic ovine model of PCOS we reported hyperinsulinaemia and early ...

ea0038p222 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Transcriptional profiles explain insulin hypersecretion following chronic adrenergic stimulation in foetal sheep islets

Kelly Amy , Chen Xiaochuan , Bidwell Christopher , McCarthy Fiona , Limesand Sean

Prolonged increases in foetal plasma noradrenaline occur in pathologies, including intrauterine growth restriction (IUGR). Infusion of noradrenaline into healthy sheep foetuses showed continuous suppression of insulin secretion but produced a compensatory beta-cell response after noradrenaline infusion was terminated, similar to findings with adrenergic antagonists in IUGR foetuses. Hyper-insulin secretion responsiveness was confirmed in isolated foetal islets. To identify mol...

ea0038p223 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Measuring the contribution of de novo lipogenesis to fatty liver disease: a mouse and translational human study using high resolution mass spectrometry

Sanders Francis , Harvey Matthew , Ament Zsuzsanna , Tingley Jessie , Vacca Michele , Griffin Julian

De novo lipogenesis (DNL) is recognised as potentially contributory to pathogenesis of non-alcoholic fatty liver disease (NAFLD), and could be a factor in the progression of simple steatosis to steatohepatitis, although it contributes a relatively minor amount of whole body fat compared to dietary lipid. Consequently understanding the lipidome during induced DNL may provide insight into potential biomarkers of DNL that could be clinically relevant in those at risk of ...

ea0038p224 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

The hypoglycaemic and antioxidant properties of oleanolic acid ameliorate blood pressure and kidney function of experimental animals

Khathi Andile , Mbatha Bonisiwe , Musabayane Cephas T

The wide range of phytochemicals in medicinal plants serves as sources of bioactive compounds for treatment diabetic complications. We investigated whether Syzygium aromaticum-isolated oleanolic acid (OA) has beneficial effects on some diabetic complications in STZ-induced diabetic rats. We used experimental models of hypertension [spontaneously hypertensive (SHR) and Dahl salt-sensitive (DSS)] rats to explore the effects of OA on mean arterial blood pressure (MAP) and renal f...

ea0038p225 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Dietary cocoa (Theobroma cacao) and turmeric (Curcuma longa) consumption: a comparison of metabolic effect in high-fat fed rats

Adegoke Olufeyi , Morakinyo Olufemi , Adekunbi Daniel , Ajibola Wurola

A growing number of studies have reported beneficial health effects of cocoa and turmeric, including atherosclerosis, hypertension and insulin resistance. Relatively few studies have investigated the preventive or therapeutic effects of cocoa and turmeric against obesity-related metabolic disorders and co-pathologies. The study was undertaken to determine the effects of cocoa and turmeric powder supplementation on glucose tolerance, insulin sensitivity and lipid profile in rat...

ea0038p226 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Glucose tolerance, insulin sensitivity and adiponectin level in niacin-treated obese rats

Morakinyo Olufemi , Samuel Titilola , Adekunbi Daniel , Adegoke Olufeyi

We examined the effect of dietary niacin supplementation on fat mass, glucose control, insulin sensitivity, lipid profile, and adiponectin level in diet-induced obese rats. Twenty-one male Sprague-Dawley rats (n=21) were initially divided into two (2) groups of seven and fourteen rats; the group of 14 rats was fed with a high-fat-diet (HFD) and the other group of 7 rats consumed the control diet. Eight weeks after the diet regimen started, half of the rats from the HFD group w...

ea0038p227 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Circadian rhythm of ambulatory blood pressure in rotating night shift nursing professionals and its relation with 6- sulfatoxy melatonin as neuroendocrine chronomolecule

Anjum B , Verma Narsingh , Tiwari Sandeep , Singh Ranjana , Mahdi Abbas

Background & aim: Night shift work is associated with a disruption of circadian rhythms, where a person’s internal body clock is in conflict with the rotating shift schedule. The circadian rhythm of the human body is characterized with an alternating sleep-wake cycle. Shift work has been associated with increased risk of hypertension, cardiovascular diseases and hormonal disturbances. The Present study was aimed to investigate the effects of rotating night shift on 24...

ea0038p228 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Characterising fat distribution and response to weight loss in idiopathic intracranial hypertension

Ali Fizzah , O'Reilly Michael , Botfield Hannah , Markey Keira , Tomlinson Jeremy , Arlt Wiebke , Sinclair Alexandra

Introduction: Idiopathic intracranial hypertension (IIH) occurs in young obese women (>90%) but little is known about the metabolic characteristics in these patients. We aimed to characterise IIH fat distribution, metabolic phenotype and evaluate alterations following weight loss.Methods: IIH and matched (BMI/sex) healthy obese controls were recruited. Metabolic indices (fasting lipid, glucose, insulin), anthropological measures and body composition ...

ea0038p229 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Anti-inflammatory effects of metformin and their relationship to the therapeutic action of the drug

Cameron Amy , Forteath Calum , Beall Craig , Rena Graham

Improvements in circulating cytokine levels have occurred in patients with endometriosis and chronic heart disease when prescribed the type 2 diabetes (T2D) drug metformin. However it is unclear how metformin exerts these effects and whether or not they are related to antihyperglycaemic effects in T2D. The purpose of this study is to investigate the relationship between anti-inflammatory and anti-hyperglycaemic effects of metformin in the liver, the main target tissue of the d...

ea0038p230 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Maternal overnutrition programs hypothalamic neuropeptides and metabolic syndrome in offspring

Ramamoorthy Thanuja Gali , Allen Tiffany-Jayne , Davies Alison , Harno Erika , Sefton Charlotte , Wray Jonathan , Murgatroyd Christopher , White Anne

Background and objective: The prevalence of obesity is increasing worldwide and it is known that intra-uterine experience can program metabolic disorders. The hypothalamic appetite regulatory system is a key target of developmental programming by maternal nutrition. Therefore, the aim of this study was to investigate the effects of maternal overnutrition on the expression of hypothalamic genes controlling energy homeostasis.Research design: Eight week ol...

ea0038p231 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

‘Thin-fat’ phenotype in early foetal life in GDM pregnancies – novel evidence from an Indian Cohort

Venkataraman Hema , Ram Uma , Anuradhai A , Suresh S , Saravanan P

Research question: What are the differences in foetal size in early pregnancy between GDM and control.Methods: Serial foetal biometry was performed for GDM women and controls at 18–20 weeks and 28–32 weeks. At each visit, abdominal and head circumference (AC) & (HC), femur length (FL) and abdominal wall thickness (AWT) was measured along with collection of maternal data.Results: women with GDM and 184 controls had com...

ea0038p232 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Functional significance of renal gene expression changes in a mouse model of ACTH-dependent Cushing’s syndrome

Monaghan Marie-Louise , Sime Nichole , Conway Bryan , Bailey Matthew , Kenyon Christopher

Renal functions in a mouse model of Cushing’s Syndrome have been characterised by analysing RNA expression complemented by immunohistochemistry studies. A microarray of kidneys from mice infused with ACTH for two weeks identified gene transcripts that were up-regulated (70) and down-regulated (49) more than two-fold. Four separate clusters of closely correlated genes (r> 0.97; P< 0.001) were investigated in more detail. One down-regulated cluster included histocom...

ea0038p233 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Brown adipose tissue plays a role in regulating fetal growth by undergoing a gestational-dependent phenotypic change

McIlvride Saraid , Abu-Hayyeh Shadi , Papacelovoulou Georgia , Jansen Eugene , Steel Jennifer , Maragkoudaki Xanthi , Williamson Catherine

Pregnancy is associated with increased maternal plasma lipid levels, an important physiological response to support the nutritional demand of the developing fetus and mother. The homeostatic controls of metabolically active organs are known to change in response to pregnancy signals. We hypothesised that pregnancy affects brown adipose tissue (BAT) phenotype and function and as a consequence plays a role in the regulation of fetal development and growth....

ea0038p234 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Seasonal variation of HbA1c

Burgess Jordan , Broughton Paul , Leese Graham

The aim of this study was to investigate seasonal variation in haemoglobin A1c (HbA1c) using a retrospective population analysis linking HbA1c values to the time of year. The study cohort included 171 442 NHS patients from Scotland, UK. Patients were divided into three groups. The ‘stable group’ were defined as having a HbA1c that varied less than the tertile either side of the mean HbA1c. The ‘high summer’ was comprised of ...

ea0038p235 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Relationship between high-sensitivity C-reactive protein and anthropometric indices of obesity

Soyoye David , Kolawole Babatope , Ikem Rosemary , Enikuomehin Adenike

Background: Obesity contributes to the occurrence of many metabolic and cardiovascular complications including Type 2 diabetes, hypertension etc. Body adiposity is not just an energy store, but also an endocrine organ with elaboration of hormones and cytokines. Some of these cytokines have been implicated in the initiation and propagation of inflammation, and hence atherosclerosis.Aim: This study examined the relationship between high-sensitivity C-react...

ea0038p236 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

2β-hydroxybetulinic acid 3β-caprylate: an active principle from euryale ferox salisb. seeds with antidiabetic, antioxidant, pancreas & hepatoprotective potential in streptozotocin induced diabetic rats

Ahmed Danish , Sharma Manju , Kumar Vikas , Bajaj Harish Kumar , Verma Amita

Introduction: The aim of the present study was to evaluate the glycaemic control, antioxidant, pancreas and liver protective effect of 2β-hydroxybetulinic acid 3β-caprylate (HBAC) from Euryale ferox Salisb. seeds on streptozotocin induced diabetic rats.Materials & methods: The active principle was isolated from Euryale ferox Salisb. seeds extract by utilizing chromatographic techniques. The rats were divided into seven exp...

ea0038p237 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Clinical profile and outcome of patients with hyperglycaemic emergencies presenting at a rural hospital in southern Nigeria

Olugbemide Orebowale , Adunbiola Patrick , Bankole Idowu , Akhuemokhan Kennedy

Background: Hyperglycaemic emergencies (HEs) continues to be important causes of morbidity and mortality among persons with diabetes mellitus. Hyperglycaemic hyperosmolar state (HHS) and diabetic ketoacidosis (DKA) are the two most common acute metabolic complications seen in persons with diabetes mellitus.Objective: To describe the clinical presentation and outcome of patients with hyperglycaemic emergencies.Materials and methods:...

ea0038p238 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Diabetic neuropathy: an evaluation using the ntss-6 questionnaire and biothesiometry in type 2 DM patients

Lawal-Bello A T , Owolabi F A , Yusuff O T , Amjo O O , Raiyemo O A , Kolawole B A , Ikem R T

Background & objectives: Vibration perception threshold (VPT) is the gold standard for diagnosis of diabetic peripheral neuropathy. The relationship between symptom severity and VPT remains to be determined. This study evaluated the diagnostic utility of symptoms using the NTSS-6 symptom score vis a vis Bio-thesiometry.Methods: diabetic patients with symptoms suggestive of peripheral neuropathy and 40 apparently healthy controls were studied. Detaile...

ea0038p239 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Hypothalamic glucocorticoid levels increase in an in vivo model of glucocorticoid-induced obesity and hyperinsulinaemia

Sefton Charlotte , Harno Erika , Davies Alison , Small Helen , Allen Tiffany-Jayne , Wray Jonathan , Ramamoorthy Thanuja Gali , Coll Anthony P , White Anne

Glucocorticoid (Gc) excess, either endogenously produced (Cushing’s syndrome) or as a result of exogenous steroid treatment, can cause metabolic disorders such as obesity and hyperglycaemia. The contribution of centrally acting corticosterone in the development of these metabolic disorders is unknown. Gcs regulate the anorexigenic and orexigenic neuropeptides (POMC and AgRP) within the arcuate nucleus of the hypothalamus to modulate energy balance. This study investigated...

ea0038p240 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Effects of androgen on the adipokinome and metabolic genes in white and brown adipose tissue

Lerner Avi , Kewada Drashti , Okolo Anthony , Hardy Kate , Franks Stephan

Polycystic ovary syndrome (PCOS) is a common endocrinopathy that is associated with an adverse metabolic profile including insulin resistance and dyslipidaemia. Hyperandrogenism is the hallmark of PCOS and obesity increases androgen synthesis, partly due to accompanying hyperinsulinemia but also as a result of adipokines affecting ovarian steroidogenesis (Comim et al., 2013, PLoS ONE 8(11). Adipokines are factors secreted by adipose tissue and while a clear link betwe...

ea0038p241 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

From the bronze age to the iron age

Grecian Sheila , Adam Safwaan , Syed Akheel

A 53 year old man, without any previous medical history, presented acutely to the Accident and Emergency Department with a 5 day history of vomiting and abdominal pain on a background of weight loss, fatigue, polyuria and polydipsia for 4 weeks. On examination he was obviously tanned and thin. He was clinically dehydrated and had palpable hepatomegaly. Immediate biochemical testing revealed hyperglycaemia with a venous blood glucose of 20.7 mmol/l, a metabolic acidosis with a ...

ea0038p242 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Characterisation of the astrocytic response to acute and recurrent hypoglycaemia

Walker Julia Vlachaki , Ashford Mike , McCrimmon Rory , Beall Craig

Background: In diabetes, exposure to frequent episodes of hypoglycaemia diminishes a persons awareness of hypoglycaemia, by poorly defined mechanisms. Evidence suggests that, at least in part, changes in cell behaviour within the ventromedial hypothalamus may contribute to this defect and that changes in AMP-activated protein kinase (AMPK), a key glucose-sensing enzyme are involved. Evidence suggests there are (mal)adaptations within neurons, however, little is known about cha...

ea0038p243 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Markers of adipose tissue hypoxia are elevated in subcutaneous adipose tissue of morbidly obese patients with hypoventilation syndrome and obstructive sleep apnoea syndrome but not in the moderately obese

Todorčević Marijana , Austen Luke , Manuel Ari , Michailidou Zoi , Stradling John , Karpe Fredrik

Adipose tissue (AT) dysfunction is thought to be a central component in the pathophysiology of obesity-associated metabolic disease. Low AT oxygenation (hypoxia) is suggested to be a driver of this dysfunction, yet studies in humans have resulted in conflicting data. Therefore, we aimed to investigate if markers of AT hypoxia were present in the subcutaneous AT of morbidly obese individuals who had hypoxia from obesity hypoventilation syndrome (OHS), with or without obstructiv...

ea0038p244 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Prevalence of diabetes mellitus among HIV patients in Kano, northwestern Nigeria

Muhammad Fakhraddeen , Uloko Andrew , Ramalan Mansur , Adenike Enikuomehin , Mukhtar Rahila , Muhammad Fauziyyah

Background: Highly active antiretroviral therapy (HAART) particularly protease inhibitors cause hyperglycaemia through insulin resistance. There is raising number of HIV patients on HAART attending the diabetic clinic in Nigeria and very few studies were done to determine their risk of developing diabetes. We aimed to determine the prevalence and factors associated with diabetes mellitus (DM) among HIV patients.Methods: In a cross sectional study of 300 ...

ea0038p245 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Obstructive sleep apnoea and bariatric surgery: the need for more universal screening and post-operative follow up

Martinou Chrysiis , Nayak Ullal , Katreddy Mahesh , Varughese George , Varadhan Lakshminarayanan

Aim: Bariatric surgery can provide significant weight loss but a complete resolution obstructive sleep apnoea (OSA) cannot be predicted. The aim of our audit was to assess the prevalence of OSA in bariatric clinics and outcomes after malabsorptive bariatric surgery.Methods: Retrospective observational analysis was performed on patients who had undergone bariatric surgery (laparoscopic gastric bypass and sleeve gastrectomy) and completed a minimum of 6 mo...

ea0038p246 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

The effect of soy protein with and without isoflavones in men with type 2 diabetes mellitus and subclinical hypogonadism: a randomised double-blind parallel study

Sathyapalan Thozhukat , Thatcher Natalie J , Rigby Alan S , Kilpatrick Eric S , Atkin Stephen L

Isoflavones are a subgroup of phytoestrogens and have a chemical structure similar to oestrogen, leading to concerns regarding possible adverse effects of isoflavones in men. Testosterone levels in men with type 2 diabetes mellitus (T2DM) are lower.Materials and methods: A randomised double-blind, parallel study was undertaken with 200 men with T2DM, of median age of 50 years (25th/75th centiles; 50, 55) years with a total testosterone level ≤12 nm...

ea0038p247 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Is polycythaemia a marker of an increased cardiovascular risk in transmen?

Naing Aye , Lei Lily , Jones Katie , Barrett James , Seal Leighton

A retrospective single centre audit was conducted on the effects of polycythaemia in trans-male and native male.Polycythaemia is a recognised side effect of testosterone treatment. It could be viewed as a maker of excess testosterone action. We examined whether lipid profiles as a marker of cardiovascular risk differed in a population of polycythaemic transmen (TM) and native males (NM).Forty-six NM and 12 TM were identified to hav...

ea0038p248 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Cost of illness among patients with diabetic foot ulcer in secondary and tertiary health facilities in Kano, northwestern Nigeria

Muhammad Fakhraddeen , Pedro Lateefah , Suleiman Hassan , Adenike Enikuomehin , Mukhtar Rahila , Muhammad Fauziyyah , Uloko Andrew

Background: In Nigeria, the economic burden of diabetes foot ulcer is enormous for several reasons and there are very few studies that look at the economic cost of diabetes foot care. This study estimated the cost of illness among patients with diabetes foot ulcer in secondary and tertiary health facilities in Kano.Methods: The study was a cross-sectional evaluation involving ninety patients with diabetes having various degrees of foot ulcerations. A str...

ea0038p249 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Impact of DAFNE and subsequent CSII therapy on glycaemic control in type 1 diabetes mellitus

Yunus Saba , Forde Hannah , Browne Sonya , Twamley Helen , Fanning Eimear , Smith Diarmuid

Background: Dose adjustment for normal eating (DAFNE) structured education programme is an effective tool in improving glycaemic control in patients with type 1 diabetes while reducing the frequency of hypoglycemic episodes. DAFNE however, does not solve all glucose related problems and patients often request or are recommended continuous subcutaneous insulin infusion (CSII) therapy post DAFNE.Objective: Out of our 370 DAFNE graduates, 46 have subsequent...

ea0038p250 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Lifelong exposure to sewage sludge chemicals causes proteome-wide and sex-specific disturbances in the liver

Filis Panagiotis , Eaton-Turner Emily , Bellingham Michelle , Amezaga Maria , Mandon-Pepin Beatrice , Evans Neil , Sharpe Richard , Cotinot Corinne , Rhind Stewart , O'Shaughnessy Peter , Fowler Paul

Introduction: A complex cocktail of endocrine-disrupting and other chemicals is ubiquitous in the modern environment. Exposure to such chemicals contributes to diseases including metabolic syndrome and infertility. The liver is the primary defence organ against xenotoxicants, but also the source of major of plasma proteins, and growth factors/hormones.Aim: To understand how chronic exposure to complex mixtures of chemicals at human and environmentally re...

ea0038p260 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

GLP1 agonist based therapy has modest effect on weight and glycaemic control among UAE patients with diabetes: analysis of data on 3725 patients

Almazrouei Raya A , Alkaabi Fatima M , Lessan Nader , Hassan Sama , Barakat Maha T

Background and aims: GLP1 agonists are used in UAE for diabetes and obesity management (prevalence of 19 and 74% respectively). Few outcome data on GLP1 agonist therapy in this population is available. We investigated the effects of two commonly used GLP1 agonists on weight and HbA1c among UAE patients with diabetes.Materials and methods: Data was retrieved from a computerized database of patients attending a large diabetes center in UAE. Patients on exe...

ea0038p261 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Extracts of Hymenocardia acida ameliorate insulin resistance in skeletal muscle cells

Ezeigbo I I , Gibbons S , Cleasby M E

There are a limited range of drugs available to treat type 2 diabetes (T2D) and insulin resistance (IR) that are efficacious and inexpensive. In West Africa, extracts of Hymenocardia acida are frequently used. However, few objective studies have yet attested to their efficacy. Here we evaluated the potential for extracts of H. acida to overcome IR in muscle in vitro.Crude extracts of H. acida were prepared in methanol ...

ea0038p262 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

A study of metabolic syndrome among HAART naïve HIV patients in Kano, northwestern Nigeria

Muhammad Fakhraddeen , Ramalan Mansur , Adenike Enikuomehin , Mukhtar Rahila , Muhammad Fauziyyah , Gezawa Ibrahim

Background: Most studies of the metabolic syndrome (MS) among HIV patients focus on those receiving HAART. This study determined the prevalence and factors associated with MS among HAART naïve HIV patients in Kano, Nigeria.Methods: In this descriptive study, we evaluated 150 consecutive HAART naive HIV patients attending the HIV clinic of Aminu Kano Teaching Hospital. Data on socio-demography, relevant clinical history, anthropometric indices, and b...

ea0038p263 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Anthropometric indices: optimal cut-off values for abdominal obesity in adult Nigerians

Umuerri Ejiro , Ayandele Christiana , Eze Godson , Anizor Chinedu

Introduction: Central obesity has been linked more to adverse cardiovascular risks than general obesity. The cut-off values for BMI, waist circumference (WC), waist:hip ratio (WHR), and waist:height ratio (WHtR) have been shown to vary with ethnicity. This study sets out to determine the optimal cut-off values for obesity in adult Nigerians using four anthropometric indices.Method: In a cross-sectional study of adults in Delta State, Nigeria, data on wei...

ea0038p264 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Influence of gender on the distribution of type 2 diabetic complications at the Obafemi Awolowo Teaching Hospital, Ile-Ife, Nigeria

Enikuomehin Adenike , Kolawole Babatope , Ikem Rosemary , Soyoye Bukunmi

Background: Gender specific differences appear particularly relevant in the overall management and outcome of type 2 diabetes mellitus (T2DM). We determined gender specific differences in cardio-metabolic risk, microvascular, and macrovascular complications in patients with T2DM.Method: Four hundred T2DM patients matched for age and disease duration were studied. Relevant clinical information, physical examination and laboratory data were analysed.<p...

ea0038p265 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

A study of the influence of West African ethnicity and gender on β-cell function and insulin sensitivity in essential hypertensives treated with hydrochlorothiazide and hydrochlorothiazide–lisinopril combination

Olamoyegun Micheal , Kolawole Babatope , Ajayi Adesuyi

Background: We assessed the effects of hydrochlorothiazide given alone and in combination with an ACEI on β-cell function in a negroid population to further explore possible ethnic differences in the effect of antihypertensive drugs on HOMA-IR.Materials and methods: Eighty newly diagnosed Nigerian essential hypertensive patients were assigned to receive either hydrochlorothiazide 25 mg daily or both hydrochlorothiazide and lisinopril (25/10 mg daily...

ea0038p266 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Comparison of surrogate measures of percentage body fat with bioelectric impedance in Nigerians

Boladae Alalade , Sandra Iwuala , Ife Odeniyi , Olufemi Fasanmade , Augustine Ohwovoriole

Background: Quantifying the body fat percentage (%BF), its scientific and clinical implications is critical to timely intervention as it has been proven to be a better measure of patient’s risk of cardiovascular diseases than the BMI. Several techniques have been developed to assess BF including imaging, DEXA, bioelectric impedance analysis (BIA), and underwater weighing. The use of anthropometric indices to derive %BF provides an inexpensive surrogate. There are very few...

ea0038p267 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Evidence of foetal growth restriction in South-Asian foetuses of GDM mothers?

Venkatarman Hema , Craik Sam , Sukumar Nithya , Saravanan Ponnusamy

Research question: Are there ethnic differences in foetal growth patterns in GDM?Methods: Retrospective data collection was undertaken for all women with GDM between 2008 and 2012 at University Hospital Coventry. Foetal biometric data was obtained at 28, 32, and 36 weeks gestation for 125 South-Asian (SA) and 142 WC.Results: Compared to WC, SA had had lower BMI (28.5±6.1 kg/m2 vs 32.2±7.4 kg/m2), hei...

ea0038p268 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Prediabetes incidence and risk of developing cardiovascular disease in women with polycystic ovary syndrome

Asimi Zelija Velija , Semiz Sabina , Dujic Tanja

Objective: In this study we analysed the prediabetes incidence in women with polycystic ovary syndrome (PCOS), as well as prediabetes and cardiovascular disease (CVD) risk factors in women with PCOS.Methods: This study included 148 women with PCOS, with no type 2 diabetes mellitus (T2DM) and CVD present at the baseline. We determined a comprehensive panel of biochemical parameters, including lipid profile, glucose and insulin levels during oral glucose t...

ea0038p269 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Improving glycaemic control in T1DM: the Fife Insulin and Food Education for Diabetes (FIFE Diabetes) structured education programme

Boyle Luke , Jamieson Fiona , Burns Denise , Duncan Katie , Malcolm Jill , White Leslie , Chalmers John , Osborne Louise , Patterson Catherine

Background: The 2013 Scottish Diabetes Survey demonstrated that only 22% of individuals with type 1 diabetes have optimal glycaemic control, defined as a HbA1c <58 mmol/mol. The 2014 Diabetes Improvement Plan in Scotland prioritised, ‘improving the care and outcomes of all people living with type 1 diabetes’. Scotland’s Diabetes Education Advisory Group has now been established. Accordingly, the Fife Insulin and Food Education for Diabetes (FIFE Diabetes) st...

ea0038p270 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Intra-Individual correlation between flow mediated dilation and reactive hyperaemia peripheral arterial tonometry in PCOS

Ehtesham Ehtesham , Javed Zeeshan , Kilpatrick Eric S , Atkin Stephen L , Sathyapalan Thozhukat

Background: Endothelial damage is one of the early signs of cardiovascular disorders. Assessing endothelial function in women with polycystic ovary syndrome (PCOS) has shown evidence of cardiovascular disease in the absence of clinically evident disorder. Flow mediated dilation (FMD) and reactive hyperaemia peripheral arterial tonometry (RH-PAT) are the frequently used non-invasive techniques for assessing endothelial function. Both the techniques have been used to assess endo...

ea0038p271 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Evaluation of hypoglycaemia unawareness in individuals with type 1 diabetes mellitus using continuous glucose monitoring in a tertiary care centre

Naik Dukhabandhu , Shilpa R M , Mahesh D M , Asha H S , Kapoor Nitin , Paul Thomas , Padmanabhan V , Inbakumari Mercy , Christina Flory , Rani Jansi , Natarajan Divya , Jeyaseelan L , Thomas Nihal

Background: Intensive glycemic control forms the benchmark of management of type 1 diabetes mellitus (T1DM) and is limited by the risk of hypoglycaemia. Repeated episodes of hypoglycaemia can lead to development of hypoglycaemia unawareness and a sixfold increase in deaths in those experiencing severe hypoglycaemia. Severe hypoglycaemia occurs in 35–42% patients with T1DM. However, there is lack of data from our population and hence we aimed to objectively estimate the pr...

ea0038p272 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Postnatal screening in patients with gestational diabetes

Patel Nishal Nimish , Malhotra Yamini , Sagi Satyanarayana , Butt Muhammad Imran

Introduction: Approximately 700 000 women give birth in England and Wales each year with up to 5% of these women having either pre-existing diabetes or gestational diabetes (GDM). Women who have diabetes during pregnancy, it is estimated that approximately 87% have GDM. It is well recognised that early diagnosis of diabetes aids in timely intervention to reduce long-term complications.Objectives: To assess the screening for diabetes mellitus in post-deli...

ea0038p273 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Prevalence of vitamin D deficiency and its association with diabetes in a South-Asian population

Gunawardane Kavinga , Somasundaram Noel , Thalagala Neil , Chulasiri Pubudu , Fernando Sudath

Introduction: Sri Lanka has been experiencing rapid urbanization, with ~30% of the population residing in urban areas. We report the age and sex-specific prevalence of dysglycaemia and vitamin D (VitD) status, along with the association between the two in an urban community in Sri Lanka.Methodology: Using a stratified random sampling method, 369 subjects (116 men and 253 women) aged 18 years and above, were tested for 25OH VitD3, 75 g OGTT, and HbA1c. De...

ea0038p274 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

What the mouth has to say about diabetes in a Nigerian Tertiary Hospital

Stella Ogunmuyiwa , Olubiyi Adesina , Boladale Alalade , Adedeji Otukoya , Titilope Adewusi , Oluwale Olukunle , Adejoke Bello

Introduction: The mouth is said to be the body’s mirror. Diabetes can be associated with the development of various types of disorders within the oral cavity of which periodontal disease is about the commonest and may indeed be the first manifestation of diabetes.Aim: To evaluate the oral health of individuals with diabetes at Federal Medical Centre, Abeokuta, Nigeria.Methodology: Descriptive study carried out between January ...

ea0038p275 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Anthropometric indexes correlate of body fat percentage among Nigerians

Ajani Gbadebo , Olamoyegun Michael

Background: Obesity is significant risk factor for cardiovascular diseases and type 2 diabetes mellitus. Many anthropometric indexes are now being used in clinical practice to identify and determine the prevalence of obesity.Aim: This study determined the relationship between common anthropometric indexes and percentage body fat (%BF).Methodology: Ninety-four volunteer subjects participated in this cross sectional hospital based st...

ea0038p276 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Lipid profile in apparently healthy Nigerian adults

Ramalan Mansur , Uloko Andrew , Fakhradeen Muhammad , Gezawa Ibrahim

Background: The lipid profile of healthy adults in northern Nigeria is scarcely reported in literature. Yet, hospital records show increasing frequency of dyslipidemia-related illnesses like CVA, MI, and peripheral vascular diseases in practice. We aim to report the pattern of lipid abnormalities in a rural population in Kano, Nigeria.Methods: A population screening of apparently healthy adults resident in sub urban community in Kano was undertaken over ...

ea0038p277 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Overweight and obesity in a rural Nigerian adult population

Ramalan Mansur , Aishatu Bage , Fakhrudeen Muhammad

Objective: To determine the prevalence of overweight and obesity and it’s associated risk factors in a rural population in Kano, northwestern Nigeria.Materials and methods: Thousand and twenty four men and women aged 18 years and above, who reside in Kumbotso ward in Kano, northwestern Nigeria were enrolled into the study using a multistage random sampling technique over a 5 months period (November 2014–April 2015). Anthropometric indices, heig...

ea0038p278 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Comparison of glycaemic control in patients with type-1 diabetes mellitus on CSII therapy with different basal rates

Yunus Saba Yunus , Forde Hannah , Browne Sonya , Moore Anne , Fanning Eimear , Smith Diarmuid

Background: There are very few studies comparing glycaemic control in patients with different basal rates on Continuous Subcutaneous Insulin Infusion therapy (CSII), so the ideal number of basal rates for a patient is not clear.Objective: To compare the glycaemic control between patients with different basal rates.Methods: Data were collected from hospital’s database and by contacting patients via phone....

ea0038p279 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Effects of gypenoside on pancreatic beta cell function and insulin secretion

Patibandla Chinmai , Patterson Steven , Shu Xinhua

Diabetes Mellitus is a chronic disease characterised by hyperglycaemia due to peripheral insulin resistance and/or insulin deficiency. This may be due to a decline in viable pancreatic β-cells number or β-cell dysfunction leading to impaired nutrient-induced insulin secretion. The most probable causes of these β-cell effects are exposure to elevated levels of inflammatory cytokines, glucose and free fatty acids. There are many synthetic and herbal drugs availabl...

ea0038p280 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

GPR142 plays a critical role in Tryptophan-induced insulin and incretin secretion in mice

Lin Hua , Efanov Alexander , Fang Xiankang , Beavers Lisa , Wang Xuesong , Gonzalez Isabel , Ma Tianwei

Nutrient sensors mediating the stimulatory effects of food-derived carbohydrates and lipids on incretin and insulin secretion have been widely studied. However, mechanisms underlying amino acid regulation of those processes remain poorly understood. GPR142 was recently reported to be highly expressed in pancreatic beta cells and selectively activated by L-Tryptophan (L-Trp). Moreover, synthetic GPR142 agonists were demonstrated to stimulate glucose-dependent insulin secretion ...

ea0038p281 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Inborn errors of metabolism and the endocrinologist

Bashari Waiel A , Oyibo Samson O

Introduction: Patients with life-threatening inborn errors of metabolism are usually managed at specialist care centres. These patients are living longer and some of them have migrated to areas far from their specialist care centres. We present two such cases.Case 1: A 37 year old female with Ornithine Transcarbamylase Deficiency (OTCD), well-managed at a specialist care centre since childhood, relocated a few times before settling down in our area. OTCD...

ea0038p282 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

An unusual case of fish odour syndrome – tabloid paper helped in diagnosis?

Basu Ambar , Banerjee Moulinath

Introduction: Trimethylaminuria or Fish Odour syndrome is a rare genetic metabolic disorder. It can cause significant suffering to affected individuals due to social isolation and stigma. It is under recognised and ignored.The case: A 60 years old lady was referred by her GP. The referral – ‘She feels she has a problem with personal hygiene and is aware of an odour from her skin, her breath and urine.’ This lady has been suffering from thi...

ea0038p283 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

eGFR using CKD- EPI, MDRD and COCKCROFT – GAULT and glycaemic control among type 2 diabetics in an out-patient clinic in Nigeria

Onwah Amanda , Ayandele Omotola , Chike- Ezue Eunice , Kweki Anthony

Introduction: Diabetic nephropathy remains a major cause of morbidity and mortality for persons with diabetes mellitus. Globally, most patients with diabetes are in developing countries that do not have the resources or health infrastructure to provide universal renal replacement therapy. The ADA recommends that estimated glomerular filtration rate (eGFR) be calculated using serum creatinine for diabetics at least once a year.Objectives: To determine the...

ea0038p284 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Correlates of dysglycaemia and implications for diabetes care in Calabar, Nigeria

Enang Ofem , Akinlade Akinyele , Fasanmade Olufemi , Ohwovoriole Augustine

Background: Besides differences in the overall prevalence between IGT and IFG, there is now clear evidence of differences in phenotype between the two categories. The most consistent and statistically significant difference is that IFG is commoner in men than women in virtually all age groups, typically being 1.5–3 times higher, but up to seven or eight times higher in Europeans aged 50–70 years. Conversely, the prevalence of IGT is higher in women than men in all ag...

ea0038p285 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Prevalence and risk factors for obesity among HIV patients in Kano, north western Nigeria

Muhammad Fakhraddeen , Uloko Andrew , Ramalan Mansur , Adenike Enikuomehin , Mukhtar Rahila , Muhammad Fauziyyah

Background: Weight gain is a recognised effect of HAART which occur through restoration of the body’s immune function and lipodystrophy. Weight gain could have a negative impact on the medical and social wellbeing of the persons affected. Most HIV studies in Nigeria tend to concentrate on the effect of HAART on viral suppression and improvement in quality of life neglecting other consequences of the disease and treatment. We aimed to determine the prevalence of obesity am...

ea0038p286 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Relationship between three indices of central obesity and fasting plasma glucose

Raimi Taiwo , Odewabi Adesina , Odusan Olatunde , Fasanmade Olufemi

Objectives: Obesity is a risk factor for Type 2 diabetes mellitus. This study evaluated the relationship between central obesity and fasting plasma glucose (FPG).Materials and methods: A cross-sectional study involving five hundred and twenty one (521) adult participants (134 males and 387 females) of a community health survey in Sagamu, Isara and Ode-Remo, Nigeria. The waist circumference (WC), waist-to-hip ratio (WHR) and waist-to-height ratio (WHtR) o...

ea0038p287 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

How well do front line healthcare professionals understand type 2 diabetes?

Boland Xavier , Martin Rhys , Yarwood Suzannah , Browne Duncan

The in-hospital pharmacological management of patients with diabetes has recently been identified by the National Diabetes Inpatient Audit as a key safety issue. Over 30% of inpatient drug charts surveyed in the 2013 audit had at least 1 diabetes medication error in the preceding week. Patients with a diabetes medication error on their drug chart were also twice as likely to have one or more hypoglycaemic episodes during their hospital stay.A paper by Br...

ea0038p288 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Accuracy and reliability of glucose meters used at diabetes clinic of Oauthc Ile Ife

Owolabi Funmilayo , Yusuff Oluwatomi , Lawal-Bello Amina , Ala Oluwabukola , Amjo Oluwadamilola , Raiyemo Adenike , Adedeji Tewogbade , Kolawole Babatope , Ikem Rosemary

Background: Self-monitoring of blood glucose (SMBG), an important tool in diabetes management help patients achieve and maintain target glycaemic levels hence reducing complications. SMBG is usually done with glucose meters which are affordable, portable and easy to use. Significant variations sometimes observed in glucose meter readings necessitated this study. We evaluated the accuracy of glucose meters used routinely in our unit using ISO 15197 guideline.<p class="abste...

ea0038p289 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Behavioural risk factors for diabetes mellitus: a study of secondary school staff in a community in south west Nigeria

Ojo Olubukola , Ilesanmi Olayinka , Omotoso Bridget , Ojo Olalekan , Junaid Oladimeji

Introduction: The prevalence of type 2 Diabetes is increasing worldwide. It is associated with significant morbidity and mortality, hence the need for early identification of risk factors. This study therefore aimed to determine the overall knowledge of the participants about Diabetes Mellitus and to assess its risk factors.Method: A cross sectional survey of 118 staff of three secondary schools in Owo was conducted using a structured self-administered q...

ea0038p290 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Influence of deuterium depleted water on indicators of prooxidant-antioxidant and detoxifying systems in experimental diabetes

Dzhimak Stepan , Basov Alexander , Fedulova Lilia , Kotenkova Elena

Studying the effect of deuterium depleted water (DDW) on isotope (D/H) composition and condition of an antioxidant-prooxidant plasma and lyophilized tissues of internal organs (liver, kidney) balance appropriate indicators in rats were compared: in group 1 (n=15) consumed mineralized water (150 ppm), which by a single intraperitoneal injection of alloxan (at a dose of 17 mg/100 g body weight) was established experimental model of diabetes; group 2 (n=15) cons...

ea0038p291 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Renal function in type 2 diabetes patients at presentation in a tertiary hospital in Nigeria – a preliminary report

Ojo Olalekan , Ojo Olubukola

Introduction: The prevalence of type 2 diabetes is increasing worldwide. It is associated with significant morbidity and mortality, with majority of the patients presenting for the first time with complications. We set out to determine the renal function of type 2 DM patients presenting in our facility.Method: A cross sectional study involving 50 type 2 diabetes patients. At presentation to the DM clinic, these were interviewed using a structured questio...

ea0038p292 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Bloods glucose monitoring in diabetic inpatients – hyperglycaemia

Phung Anita , Brown Nathan , Micanovic Christina , Aloysius Isaac

Background: Hypoglycaemia is considered a medical emergency and is treated as such. However, our experience as junior doctors has shown us that hyperglycaemia, despite being equally damaging to patients’ long term prognosis, can often be left to ‘run high’. This could be due to a number of factors, surrounding how often blood sugars (BM) are checked and how they are managed. We audited three standards set out in local guidelines for BM monitoring in diabetic pat...

ea0038p293 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Case report of a type 2 DM patient with vitamin B12 deficiency anaemia

Akinlade Akinyele , Olamoyegun Michael , Enang Ofem

A 54 year-old businesswoman who has been diabetic for 6 years and had a history of PUD. She was referred following complaints of increasing hyperpigmentation of her palms, feet and old scars. She also had a boil on her back, significant weight loss, poor appetite and a slight non-productive cough.She was transfused with two pints of blood a month earlier at a private hospital when her PCV was found low. She is not hypertensive. Her drug history included ...

ea0038p294 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Relationship between anthropometric indices and insulin resistance in Nigerians with type 2 diabetes mellitus

Onwukwe Chikezie , Chikezie Nkiru

Background/aims: Insulin resistance is predominant in type 2 diabetes mellitus (DM) patients. Obesity is a risk factor for insulin resistance. This study aims to determine the relationship between indices of nutriture and insulin resistance in type 2 DM patients.Methods: This is a cross-sectional study of type 2 DM patients attending the Diabetes Clinic, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Anambra State, Nigeria and evaluated over a 6 wee...

ea0038p295 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Assessment of the relationship between obesity indices and lipid parameters among Nigerians with hypertension

Olamoyegun Michael , David Ajani , Akinlade Akinyele , Gbadegesin Babajide , Aransiola Clement , Olopade Rotimi , Ojo Olujide , Enang Ofem , Adetokunbo Stella

Background: Both obesity and presence of certain patterns of lipid abnormalities has consistently been identified as a strong determinants of cardiovascular health. In resource limited populations, it is important to ascertain methods of reducing resources utilisation by identifying simple measures to cardiovascular risk. Considering the relative ease of measuring anthropometries (BMI, waist circumference-WC, and waist-hip ratio-WHR) data, we sought to determine if any measure...

ea0038p296 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Hyperuricaemia and peripheral arterial disease in patients with diabetes mellitus

Ogbera Anthonia , Osagie Victor

Introduction: The objective of this Report is to evaluate for a possible association between serum uric acid levels and PAD in persons with diabetes mellitus.Methods: This was a cross sectional Study carried out in 232 DM patients, Anthropometric indices and ankle brachial pressure indices were documented. Biochemical analyses were carried out for lipid parameters, glycosylated haemoglobin and uric acid.Results: The mean age and ag...

ea0038p297 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Similia similibus curantur: using DPP-IV inhibitor to treat reactive hypoglycaemia

Clemente Marisa , Moulinath B

Introduction: Reactive hypoglycaemia (RH) is a complex problem, with no definite treatment apart from lifestyle changes.Methods: We used Sitagliptin in two patients with RH, who had tried lifestyle changes for at least 2 years but without much effect. A gentleman with initial BMI of 31.4 kg/m2 and another lady of BMI 24.1 kg/m2 was treated with Sitagliptin 100 and 50 mg daily, in view of their weight and thereby volume of distributi...

ea0038p298 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Clinical profile of persons with diabetes attending an endocrinology clinic in a tertiary hospital in rural Nigeria

Adunbiola Patrick , Olugbemide Ore , Bankole Idowu , Akhuemokhan Kennedy

Background: Diabetes mellitus (DM) is a leading cause of morbidity and mortality globally. Its prevalence is increasing worldwide due to the transition phase. The present prevalence of DM is projected to double in the year 2035.Materials and methods: This is an ongoing prospective observational study. Subjects were persons who had been diagnosed of DM using the World Health Organization (WHO) criteria, and had been on treatment for at least six months. S...