Searchable abstracts of presentations at key conferences in endocrinology

ea0081p524 | Adrenal and Cardiovascular Endocrinology | ECE2022

HIF-2α is detrimental for the functioning of the adrenal medulla

Watts Deepika , Bechmann Nicole , Mohr Hermine , Kruger Anja , Pellegata Natalia S. , Eisenhofer Graeme , Peitzsch Mirko , Wielockx Ben

The adrenal gland is a crucial regulator of numerous fundamental biological processes and its hormones are essential for maintaining homeostasis in normal and stressful situations. However, the impact of hypoxia signalling on the function of the adrenal remains poorly understood. During the past years, our research group has focused on enhancing our understanding of hypoxia pathway proteins (HPPs) in the different areas of the adrenal gland. Firstly, we described a crucial rol...

ea0081ep55 | Adrenal and Cardiovascular Endocrinology | ECE2022

The asymmetric adrenal in mice and men: Sexual dimorphism and potential hormonal consequences

Bechmann Nicole , Moskopp Mats Leif , Watts Deepika , Steenblock Charlotte , Kanczkowski Waldemar , Wielockx Ben , Bornstein Stefan R , Peitzsch Mirko , Eisenhofer Graeme

Evidence indicates that the adrenals are sexually dimorphic and asymmetric. These differences may have implications for the prevalence and progression of adrenal diseases, which also show asymmetry and sexual dimorphism. The present study aims to characterize the morphological and metabolic differences associated with adrenal sex and asymmetry in mice and humans. Adrenals were compared bilaterally in male and female C57B/6NRj mice with regard to morphological and hormonal char...

ea0099p419 | Adrenal and Cardiovascular Endocrinology | ECE2024

Primary aldosteronism: Small molecule antagonists of mutant KCNJ5 potassium channels

Mir-Bashiri Sanas , Tetti Martina , Froebel Dennis , Reiss Dunja , Bechmann Nicole , Peitzsch Mirko , Eisenhofer Graeme , Reincke Martin , Williams Tracy Ann

Background: Primary aldosteronism (PA) is the most frequent cause of endocrine hypertension associated with excess aldosterone production from one or both adrenal glands. Somatic or germline mutations in the KCNJ5 potassium channel cause an imbalance in intracellular ion homeostasis. This ultimately drives aldosterone overproduction in some sporadic forms of PA and a familial form of the disease (familial hyperaldosteronism type 3). Our objective was to identify small molecule...

ea0081oc6.1 | Oral Communications 6: Endocrine-Related Cancer | ECE2022

Recurrent disease in patients with sporadic pheochromocytoma and paraganglioma

Li Minghao , Prodanov Tamara , Meuter Leah , Kerstens Michiel , Bechmann Nicole , Prejbisz Aleksander , Fassnacht Martin , Timmers Henri , Beuschlein Felix , Fliedner Stephanie , Robledo Mercedes , Lenders Jacques , Pacak Karel , Eisenhofer Graeme , Pamporaki Christina

Background: It is well established that life-long follow-up is required for patients with hereditary pheochromocytomas and paragangliomas (PPGLs), due to the potential of developing recurrent disease. However, whether follow-up of patients with sporadic PPGLs is necessary, remains unclear.Aims: To examine the prevalence and predictors of recurrent disease in patients with sporadic PPGLs.Materials and method: This multicenter study included retrospective ...

ea0099rc7.1 | Rapid Communications 7: Endocrine-related Cancer | ECE2024

PRAP study - Partial versus radical adrenalectomy for hereditary pheochromocytomas

Xu Kai , Langenhuijsen Johannes , Vietor Charlotte , Feelders Richard , van Ginhoven Tessa , Elhassan Yasir , Bioletto Fabio , Parasiliticaprino Mirko , Zandee Wouter , Kruijff Schelto , AEkerstrom Tobias , Pamporaki Christina , Bechmann Nicole , Lussey-Lepoutre Charlotte , Canu Letizia , Steenaard Rebecca , Driessens Natacha , Velema Marieke , Dreijerink Koen , Engelsman Anton , Timmers Henri , de Laat Marieke

Introduction: Pheochromocytoma, a rare catecholamine-secreting adrenal tumor, can cause hypertension and life-threatening complications. Hereditary cases have an increased risk of developing bilateral disease. Standard treatment involves radical adrenalectomy, leading to adrenal insufficiency in bilateral cases. Partial adrenalectomy aims to preserve adrenal function but has higher recurrence rates. This study compares outcomes of partial vs radical adrenalectomy in hereditary...

ea0099ep223 | Endocrine-Related Cancer | ECE2024

Opposing effects of cannabidiol (CBD) on pheochromocytoma/paraganglioma and neuroendocrine tumor cell lines and individual patient-derived primary cultures

Wang Katharina , Schober Laura , Fischer Alessa , Bechmann Nicole , Maurer Julian , Peischer Lea , Reul Astrid , Hantel Constanze , Reincke Martin , Beuschlein Felix , Robledo Mercedes , Mohr Hermine , Pellegata Natalia , Schilbach Katharina , Knosel Thomas , Ilmer Matthias , Angele Martin , Kroiss Matthias , Maccio Umberto , Broglie-Dappen Martina , Vetter Diana , Lehmann Kuno , Pacak Karel , Grossman Ashley , Auernhammer Christoph , Zitzmann Kathrin , Nolting Svenja

The recreational use of cannabis is becoming more widespread since many countries, including parts of Europe, are currently discussing legalisation. Moreover, the medical use of cannabinoids is already established and has many indications such as multiple sclerosis-induced spasticity or supportive therapy in the case of tumour-associated pain or loss of weight or appetite. However, the effects of cannabinoids on tumour growth still remain largely unexplored in many tumour enti...