Searchable abstracts of presentations at key conferences in endocrinology

ea0049gp68 | Developmental & Protein Endocrinology | ECE2017

Assessment of reports of behaviour by patients and their parents in paediatric Cushing disease

Keil Margaret , Belyavskaya Elena , Lyssikatos Charalampos , Lodish Maya , Stratakis Constantine

Context: Prior studies of children with endogenous Cushing syndrome (CS) have identified cognitive decline despite reversal of brain atrophy after remission as well as residual impairment of quality of life measures. Although parental observations support personality changes with CS, significant psychopathology has not been described. We investigated the feasibility of using paediatric Patient-reported outcomes (PROMIS) using a computer interface to assess patient perception o...

ea0041gp30 | Adrenal (2) | ECE2016

Hair Cortisol Measurements in the Evaluation of Cushing’s Syndrome

Zilbermint Mihail , Hodes Aaron , Sinaii Ninet , Belyavskaya Elena , Lyssikatos Charalampos , Meyer Jerrold , Lodish Maya , Stratakis Constantine

Context: Hair cortisol has been recently studied to determine evidence of hypercortisolemia in humans. This test may be valuable in estimating cortisol levels, particularly in patients with cyclical Cushing’s syndrome (CS).Objective: To determine correlations with biochemical evidence of CS, and to compare hair cortisol measurements in patients with CS to normative data.Methods: Hair samples from 49 study subjects were collect...

ea0037ep1225 | Clinical Cases–Pituitary/Adrenal | ECE2015

Anaesthesia during petrosal sinus sampling and possible interference with ACTH levels

Keil Margaret , Lodish Maya , Lyssikatos Charalampos , Bhutani Jaikrit , Belyavskaya Elena , Stratakis Constantine

Background: General anaesthesia and surgical intervention in humans are known to affect the function of the hypothalamic–pituitary–adrenal axis (HPA). In the literature there are conflicting reports about the effect of propofol, a commonly used intravenous anaesthetic agent, on HPA function.Case reports: We report two males (11 and 12 years) with ACTH-dependent Cushing syndrome (CS) who underwent inferior petrosal sinus sampling (IPSS) with gen...

ea0035n6 | (1) | ECE2014

Effects of PRKAR1A mutations in behavior and brain function

Keil Margaret , Lyssikatos Charalampos , Shaikh Moomal , Belyavskaya Elena , Elliott Brenda , Batista Dalia , Stratakis Constantine

Background: Various genetic syndromes have identified distinct and consistent behavior patterns. Carney complex (CNC) is a rare multiple endocrine neoplasia syndrome first described by Dr Carney in 1985 as a complex of myxomas (cardiac, skin), spotty skin pigmentation, and endocrine over activity. CNC is caused by mutations of the PRKARIA gene that encodes the RIα regulatory subunit of Protein kinase A (PKA). We recently reported that a Prkar1a heterozyg...

ea0049ep13 | Adrenal cortex (to include Cushing's) | ECE2017

Hair cortisol in patients with primary aldosteronism

Hodes Aaron , Lodish Maya , Tirosh Amit , Meyer Jerrold , Belyavskaya Elena , Lyssikatos Charalampos , Rosenberg Kendra , Demidowich Andrew , Swan Jeremy , Jonas Nichole , Stratakis Constantine , Zilbermint Mihail

Context: Primary aldosteronism (PA) is a common cause of secondary hypertension, and some PA adrenal tumors co-secrete glucocorticoids, causing subclinical or overt Cushing syndrome (CS). We recently reported correlations between hair cortisol concentration (HCC) and serum and urinary levels of cortisol in patients with CS.Objective: To determine correlations of segmental hair cortisol and biochemical markers of a referred cohort of patients for the eval...