ea0073oc8.1 | Oral Communications 8: Pituitary and Neuroendocrinology | ECE2021
Tang Sicheng
, Perez-Rivas Luis Gustavo
, Albani Adriana
, Rotermund Roman
, Flitsch Jörg
, Honegger Jürgen
, Rachinger Walter
, Sigrun Röber
, Herms Jochen
, Reincke Martin
, Theodoropoulou Marily
IntroductionSomatic USP8 mutations are found in around 50% of Cushings disease tumours and are located in a single mutational hotspot that contains the recognition site for 14–3-3. These proteins bind to phosphoserine recognition motifs to alter the function and location of their target proteins, and are deregulated in several cancers. AimTo explore the expression and function of 14–3-3 prot...