Endocrine Abstracts

IntroductionSomatic USP8 mutations are found in around 50% of Cushing’s disease tumours and are located in a single mutational hotspot that contains the recognition site for 14–3-3. These proteins bind to phosphoserine recognition motifs to alter the function and location of their target proteins, and are deregulated in several cancers. AimTo explore the expression and function of 14–3-3 prot...

IntroductionOsilodrostat, a potent oral 11β-hydroxylase inhibitor, normalized mean urinary free cortisol (mUFC) in most patients with CD during the 48-week (W) core phase of a Phase III study (LINC3: NCT02180217). We present efficacy and safety results following an extension to LINC3.MethodsCD patients with mUFC > 1.5× upper limit of normal (ULN) received osilodrostat during the core. Patients b...

The pituitary gland is the master gland of the endocrine system, controlling important physiological steps like growth, puberty or reproduction. There are different endocrine cell types within the adenopituitary, each one producing a specific hormone. Adaptation to different life stages and moments requires a plastic capacity based in proliferation and differentiation of pituitary stem cells. We ans others discovered the existence of a stem cell niche in the pituitary. Parench...

Cushing’s Disease (CD) is a rare condition mostly caused by an ACTH-secreting pituitary tumor resulting in excess of cortisol release by the adrenal glands. Although pasireotide is the only pituitary-targeted drug approved to treat adult patients, many side effects are encountered during the clinical practice and a curative therapy for CD is still challenging. Recently, the discover of somatic mutations in the deubiquitinase USP8 gene in a subset of patients has ...

Background and aimMicroRNAs (miRNA) are small nucleotide sequences that affect gene expression in cells at the posttranscriptional level. Some miRNAs behave like oncogenes, while others behave like tumor suppressors. In this study, it was aimed to investigate the role of miRNAs in tumor development and its effects on clinical and metabolic parameters of the patients with acromegaly.Methods39 patients diagnose...

BackgroundCorticotroph pituitary adenomas present different degrees of functionality, from silent to whispering and finally to functioning adenomas leading to Cushing’s disease. Compared to their functioning (FCA) counterpart, the silent corticotroph adenomas (SCA) express lower levels of the corticotroph cell lineage marker–TBX19 (TPIT), proopiomelanocortin (POMC), and prohormone converting enzyme 1/3 (PC1/3, PCSK1)–t...