Endocrine Abstracts

BackgroundThymic neuroendocrine tumor (THY-NET) accounts for almost 20% of multiple endocrine neoplasia type 1 (MEN1)-associated mortality. Diagnosis at early tumor stage is associated with improved survival.ObjectiveTo study the prevalence, clinical features and prognosis of THY-NET in MEN 1. To describe the overall causes of death among the registered MEN1 patients. To compare and discuss our results with t...

Prostate cancer (PCa) is one of the leading causes of cancer deaths among men population worldwide. This tumour pathology is commonly diagnosed through the determination of serum PSA levels. However, the diagnostic capability of PSA dramatically drops when considering patients with PSA levels lower than 10 ng/ml, the so-called “grey-zone”1. Therefore, additional non-invasive diagnostic biomarkers are urgently needed to substitute/complement PSA. In this se...

IntroductionDysregulation of alternative splicing is emerging as a new hallmark of cancer. This dysregulation may originate from mutations and/or altered expression of specific components of the splicing machinery. Indeed, our group has shown that the expression profile of the splicing machinery is altered in several types of cancer, including endocrine-related cancers. However, to date, the status of alternative splicing and its putative dysregulation h...

Endocrine-metabolic alterations such as obesity and metabolic syndrome are closely linked to the development of chronic liver diseases, from metabolic-associated fatty liver (MAFLD) to non-alcoholic steatohepatitis (NASH) and hepatocellular carcinoma (HCC). An emerging hallmark of endocrine-metabolic and hepatic diseases is the appearance or altered expression of pathological splicing variants (SVs). In fact, the components of the cellular machinery involved in the splicing pr...

IntroductionFasting trial remains the gold standard to confirm the diagnosis of insulinoma, based on low blood glucose level concomitant with inadequate high insulin level. However, diagnostic criteria are not consensual. Glycemia and insulin thresholds differ between the different consensus statements : endogenous hyperinsulism diagnosis relies on a glycemia < 3 mmol/l associated with an insulin level > 3 mUI/l in Endocrine Society guidelines (2009)...

Gliomas are derived from glial-cells and are the most common primary brain tumor, characterized by rapid growth and invasion. Astrocytomas are a subset of malignant gliomas which are classified, based on their agresiveness features, in low grades (I and II) to high grades (HGAs; III and IV), being grade-IV (glioblastoma multiforme; GBM) the most malignant and aggressive type. Current standard treatment for GBMs consists on surgery followed by radiotherapy/chemotherapy; however...