Searchable abstracts of presentations at key conferences in endocrinology
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European Congress of Endocrinology 2021

22 May 2021 - 26 May 2021

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The European Congress of Endocrinology provides a global platform for the international endocrine community to discuss the latest advances in the field.

Oral Communications

Oral Communications 10: Thyroid

ea0073oc10.1 | Oral Communications 10: Thyroid | ECE2021

The role of VEGF expression in the development of papillary thyroid carcinoma in patients with lymphocytic thyroiditis

Gulcelik Nese Ersoz , Akın Şafak , Aydin Kadriye , Aydin Mericö Cisel , Usman Aydan

BackgroundVascular endothelial growth factor (VEGF) has been implicated in angiogenesis of papillary thyroid carcinoma (PTC). As VEGF expression is increased in PTC and even in lymphocytic thyroiditis (LT), we hypothesized that VEGF may play a role in the development of PTC in patients with LT. In order to find an association between VEGF and these disorders, we examined both the tumoral and adjacent tissues of PTC patients with and without LT.<p cla...

ea0073oc10.2 | Oral Communications 10: Thyroid | ECE2021

NTRK fusion genes in thyroid cancer

Pekova Barbora , Sykorova Vlasta , Mastnikova Karolina , Vaclavikova Eliska , Moravcova Jitka , Petr Vlcek , Lastuvka Petr , Taudy Milos , Cisel Rami , Bavor Petr , Kodetova Daniela , Kodetova Martin , Drozenova Jana , Kodetova Jaromir , Hrabal Petr , Vcelak Josef , Bendlova Bela

ObjectivesRearrangement involving one of the neurotrophic-tropomyosin receptor kinase (NTRK) genes belonging to the NTRK family represents a significant oncogenic event in thyroid cancer (TC). Recently, there has been a growing interest in testing and characterizing NTRK fusion genes because they are therapeutically targetable. This study aimed to determine a frequency, clinical and histopathological features of a large cohort ...

ea0073oc10.3 | Oral Communications 10: Thyroid | ECE2021

Predictive factors for recurrent non-diagnostic fine-needle aspiration biopsy in thyroid nodules

Benido Silva Vânia , Maria Teresa Vânia , Carvalho André , Freitas Cláudia

IntroductionThe most cost-effective, minimally invasive and accurate tool to discriminate benign from malignant thyroid nodules is a fine-needle aspiration biopsy (FNAB). However, 2%–24% of FNABs provide non-diagnostic results, which are a clinical challenge, particularly when this result is recurrent.AimTo determine the predictive factors for recurrent non-diagnostic FNAB in thyroid nodules.<p class...

ea0073oc10.4 | Oral Communications 10: Thyroid | ECE2021

Targeting TSHR and ICAM-1 for treatment of Graves’ disease in BALB/c mice

Zheng Wei , Wang Xuan , Li Wang , Wang Shen , Tan Jian , Jia Qiang , Meng Zhaowei , Rui Zhongying

ObjectiveIn BALB/c mice with GD model, the TSHR and ICAM-1 were targeted for treatment, and new approaches to GD targeted therapy were explored.MethodsThe siRNA targeting TSHR and the ICAM-1 mAb specifically binding ICAM-1 were designed and synthesized. Thirty GD model mice were randomly divided into siRNA treatment group, ICAM-1 mAb treatment group, and untreated GD group, with 10 mice in each group, and 10 ...

ea0073oc10.5 | Oral Communications 10: Thyroid | ECE2021

External validation of AIBx, an artificial intelligence model for risk stratification, in surgically resected thyroid nodules

Swan Kristine , Thomas Johnson , Nielsen Viveque , Jespersen Marie Louise , Bonnema Steen

BackgroundArtificial intelligence algorithms can be used in classification of thyroid nodules to reduce subjectivity. External validation on images collected from different ultrasound machines and other institutions are vital before wider use of these algorithms. We retrospectively analyzed the performance of AIBx on thyroid nodules with surgically proven pathology.Materials and methodsPatients harboring thyr...

ea0073oc10.6 | Oral Communications 10: Thyroid | ECE2021

Impact of allogeneic stem cell transplantation on thyroid function

Felicetti Francesco , Zavattaro Marco , Faraci Danilo , Gatti Filippo , Dellacasa Chiara , Busca Alessandro , Arvat Emanuela , Rosso Daniela , Marinelli Lorenzo , Margherita Dionisi-Vici , Giaccone Luisa , Bruno Benedetto , Brignardello Enrico

IntroductionPrimary hypothyroidism, which is one of the main endocrine complications of allogenic stem cells transplantation (allo-SCT), has been largely studied in children. Conversely, data on adults are still limited with a reported incidence widely ranging between 9 and 47%. Older age, multiple allo-SCT, chronic Graft vs Host Disease (cGVHD), prolonged immunosuppressive therapy and high-dose total body irradiation (TBI) have been indicated as potenti...