Searchable abstracts of presentations at key conferences in endocrinology

ea0073oc11.4 | Oral Communications 11: Adrenal and Cardiovascular Endocrinoloyg | ECE2021

The management of post-operative recurrences in patients with adrenocortical carcinoma (ACC): The experience of San Luigi Hospital

Calabrese Anna , Puglisi Soraya , Basile Vittoria , Perotti Paola , Berchialla Paola , Pia Anna , Reimondo Giuseppe , Terzolo Massimo

BackgroundThe management of post-operative recurrences of ACC remains controversial, although the current guidelines recommend a surgical approach whenever feasible with radical intent.AimThe aim of our study was to evaluate retrospectively the management of recurrences in patients with ACC. We collected data of 106 patients with ACC followed at the San Luigi Hospital for the management of recurrence. Median ...

ea0063p24 | Adrenal and Neuroendocrine Tumours 1 | ECE2019

Management of adjuvant mitotane therapy for adrenocortical carcinoma: a survey in Italy

Puglisi Soraya , Calabrese Anna , Basile Vittoria , Pivonello Rosario , Ceccato Filippo , Scaroni Carla , Torlontano Massimo , Cannavo Salvatore , Arnaldi Giorgio , Stigliano Antonio , Malandrino Pasqualino , Saba Laura , Altieri Barbara , Casa Silvia Della , Perotti Paola , Berchialla Paola , De Filpo Giuseppina , Canu Letizia , Loli Paola , Reimondo Giuseppe , Terzolo Massimo

Background and objective: Mitotane is widely used as post-operative adjuvant treatment of adrenocortical carcinoma. However, the management of therapy is largely empirical. Mitotane monitoring is recommended but we do not know what impact target concentrations do have on patient outcome. The aim of the study is to evaluate its use in expert Italian centers, analyzing data of Lysosafe Online® database.Methods: Retrospective analysis of patients repor...

ea0041oc13.1 | Pituitary Clinical | ECE2016

Acromegaly is associated with increased cancer risk: a nationwide survey in Italy on behalf of the Italian study group of acromegaly

Reimondo Giuseppe , Terzolo Massimo , Berchialla Paola , Malchiodi Elena , Arosio Maura

Introduction: That acromegaly may cause cancer remains an unsolved issue. Aim of the present study was to assess the standardized incidence ratios (SIRs) of different types of cancer in a nationwide multicenter cohort study in Italy on acromegalic patients who have been treated in the somatostatin-receptor ligands era.Methods and design: We have evaluated the prevalence of neoplasia from a series of 1512 patients who were proactively followed in 24 terti...

ea0056p116 | Endocrine tumours and neoplasia | ECE2018

Outcome of adjuvant mitotane therapy in patients with adrenocortical carcinoma: the experience of San Luigi Gonzaga Hospital

Puglisi Soraya , Calabrese Anna , Basile Vittoria , Perotti Paola , Pia Anna , Berchialla Paola , Volante Marco , Reimondo Giuseppe , Terzolo Massimo

Background and objectives: The role of adjuvant mitotane therapy after radical surgery for adrenocortical carcinoma (ACC) is still debated. The aim of our study is to assess the effects of adjuvant mitotane on recurrence free survival (RFS) and overall survival (OS) in non-metastatic ACC patients and to evaluate prognostic factors in adjuvant setting.Methods: Retrospective data were collected from 152 patients affected by ACC (stage I-III) referred to ou...

ea0070aep611 | Pituitary and Neuroendocrinology | ECE2020

Effects of different therapeutic approaches on cardiovascular risk in patients with acromegaly: Results of a multicentric study

Reimondo Giuseppe , Spagnolo Federica , Puglisi Soraya , Lombardi Stocchetti Benedetta , Ragonese Marta , Ceccato Filippo , Ferraù Francesco , Berchialla Paola , Carla Scaroni , Cannavò Salvatore , Terzolo Massimo

The association between acromegaly and increased cardiovascular morbidity and mortality is widely recognised. The aim of this retrospective multicentric study is to evaluate the impact of different therapeutic approaches on the progression of cardiovascular risk (CVR) in acromegalic patients. At diagnosis and last follow up (follow up time of 13 ± 8 years),we assessed BMI, blood pressure, glycaemic and lipid profile, GH and IGF1 levels in 199 patients with acromegaly (116...

ea0073oc11.5 | Oral Communications 11: Adrenal and Cardiovascular Endocrinoloyg | ECE2021

Results of the ADIUVO trial, the first randomized study on post-operative adjuvant mitotane in patients with adrenocortical carcinoma

Terzolo Massimo , Fassnacht Martin , Perotti Paola , Libè Rossella , Lacroix Andre , Kastelan Darko , R. Haak Harm , Arlt Wiebke , Loli Paola , Decoudier Benedicte , Lasolle Hélène , Bancos Irina , Quinkler Marcus , Barisson Villares Fragoso Maria Candida , Canu Letizia , Puglisi Soraya , Calabrese Anna , Kroiss Matthias , Dusek Tina , Bourdeau Isabelle , Baudin Eric , Berchialla Paola , Beuschlein Felix , Bertherat Jerome , Berruti Alfredo

BackgroundThe ESE-ENSAT guidelines suggest adjuvant mitotane for patients with adrenocortical carcinoma (ACC) at high risk of recurrence following radical surgery. This indication has a limited evidence base, lacking results from randomized controlled trials. No suggestion is available in low-risk patients, since studies did not stratify patients for prognosis. The randomized controlled study ADIUVO compared the efficacy of adjuvant mitotane (MIT) treatm...

ea0099p236 | Adrenal and Cardiovascular Endocrinology | ECE2024

Impact of environmental pollution on adrenocortical carcinoma in Italy

Puglisi Soraya , Calabrese Anna , Ferrau Francesco , Alessi Ylenia , Lagana Marta , Grisanti Salvatore , Ceccato Filippo , Scaroni Carla , Di Dalmazi Guido , Stigliano Antonio , Altieri Barbara , Canu Letizia , Luconi Michaela , Loli Paola , DeMartino Maria Cristina , Arvat Emanuela , Palmieri Serena , Perotti Paola , Basile Vittoria , Berchialla Paola , Berruti Alfredo , Pia Anna , Reimondo Giuseppe , Cannavo Salvatore , Terzolo Massimo

Background: Whether environmental pollution may influence adrenocortical carcinoma (ACC) development remains largely unknown. The aim of this study was to evaluate the impact of exposition to environmental pollutants on ACC presentation and prognosis in Italy.Patients and methods: A retrospective analysis was done on 500 patients affected by ACC, who were diagnosed in 12 reference centers in Italy from 1990 to 2018 and followed-up for a median of 37.5 mo...