ea0029p507 | Diabetes | ICEECE2012
Trovato L.
, Settanni F.
, Gallo D.
, Gargantini E.
, Bergandi L.
, Ong H.
, Ghigo E.
, Granata R.
RFamides are a family of peptides containing arginine-phenylalanine-amide at their C terminus. A novel 43-amino acid RFamide, named QRFP43, and a shorter endogenous peptide 26RFa, were discovered and identified as ligands of the G protein-coupled receptor GPR103. Different studies have shown that RFamides, such as neuropeptide FF and QRFP43 and 26RFa, play a role in food intake, thermogenesis and energy homeostasis. Here, we investigated the effects of QRFP peptides on surviva...