Searchable abstracts of presentations at key conferences in endocrinology

ea0049gp90 | Diabetes & complications 2 | ECE2017

The G allele of the BDKRB1 rs12050217 polymorphism is associated with protection for diabetic retinopathy

Brondani Leticia A. , Pisco Julia , Guimaraes Jorge A. , Crispim Daisy , Berger Markus

Background: Diabetic retinopathy (DR) is a chronic diabetic complication occurring in most diabetic patients after 20 years of disease. Progression of DR to its sight threatening stages is usually associated with worsening of underlying retinal vascular dysfunction and disease. The plasma kallikrein kinin system is activated during vascular injury, mediating important functions in inflammation, blood flow, and coagulation. Bradykinin B1 receptor (B1R) is expressed in human ret...