Searchable abstracts of presentations at key conferences in endocrinology

ea0038p222 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Transcriptional profiles explain insulin hypersecretion following chronic adrenergic stimulation in foetal sheep islets

Kelly Amy , Chen Xiaochuan , Bidwell Christopher , McCarthy Fiona , Limesand Sean

Prolonged increases in foetal plasma noradrenaline occur in pathologies, including intrauterine growth restriction (IUGR). Infusion of noradrenaline into healthy sheep foetuses showed continuous suppression of insulin secretion but produced a compensatory beta-cell response after noradrenaline infusion was terminated, similar to findings with adrenergic antagonists in IUGR foetuses. Hyper-insulin secretion responsiveness was confirmed in isolated foetal islets. To identify mol...