ea0029p337 | Cardiovascular Endocrinology and Lipid Metabolism | ICEECE2012
Atzori V.
, Pigliaru F.
, Vacquer S.
, Carta M.
, Spiga A.
, Bina P.
, Pili M.
, Manca M.
, Lai M.
, Mariotti S.
Introduction: Both GH and IGF1 have important effects on the heart mass and contractility and deficiency of either hormone is associated with increased cardiovascular morbidity and mortality. GH/IGF1 axis abnormalities (mostly primary or secondary IGF1-D) are frequent in adult patients with β-thalassemia major (β-Thal). IGF1-D could therefore contribute with iron overload to the hearts damage of β-Thal patients, but this question has been little investigat...