Cardiovascular Endocrinology and Lipid Metabolism

Fatty liver (Hepatic Steatosis) is common in men with type 2 diabetes mellitus (T2DM). Furthermore there is a high prevalence of testosterone deficiency (up to 40%) in this population. Testosterone replacement therapy (TRT) has been shown to reduce elevated serum liver transaminase levels in hypogonadal men. The testicular feminised (Tfm) mouse exhibits a non-functional androgen receptor (AR) and low circulating testosterone levels. We have previously shown that a high-fat die...

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ea0029p270 | Cardiovascular Endocrinology and Lipid Metabolism | ICEECE2012

Effect of testosterone on hepatic liver X receptor and ApoE expression as a potential mechanism of atheroprotection in the testicular feminised mouse

Kelly D. , Akhtar S. , Brooke J. , Channer K. , Jones T.

Testosterone deficiency is associated with several cardiovascular risk factors. Testosterone replacement therapy (TRT) improves insulin sensitivity, inflammation and cholesterol. Liver X receptor (LXR) is a nuclear receptor which regulates lipid and glucose metabolism, stimulates cholesterol efflux and ApoE, and suppresses inflammation. LXR agonists cause hepatic steatosis but protect against atherosclerosis. TRT attenuates high-cholesterol diet-induced hepatic steatosis in th...

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ea0029p271 | Cardiovascular Endocrinology and Lipid Metabolism | ICEECE2012

The effect of potassium supplementation on the endothelium, the renin-angiotensin-aldosterone system (RAAS) and blood pressure in patients at moderate cardiovascular disease risk

Graham U. , McCance D. , Young I. , Mullan K.

There is limited evidence on the effect of potassium (K+) supplementation on endothelial function. Three studies suggest a beneficial effect in healthy volunteers and mild hypertensives. However potassium increases aldosterone due to a direct effect on the adrenal gland and there is evidence that aldosterone excess is detrimental to cardiovascular health. We therefore aimed to determine the effect of potassium supplementation on endothelial function in patients with >10% c...

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ea0029p272 | Cardiovascular Endocrinology and Lipid Metabolism | ICEECE2012

(Pro)renin Receptor is essential for filtration barrier in glomerular podocyte

Kinouchi K. , Ichihara A. , Oshima Y. , Kurosawa H. , Sun-Wada G. , Wada Y. , Yamada T. , Takemoto M. , Saleem M. , Quaggin S. , Itoh H.

Backgrounds: Podocytes are highly specialized postmitotic kidney cells that contribute to maintaining the filtration barrier and normal structure of glomerular capillaries. The (pro)renin receptor (PRR), as ATP6AP2, is an accessory subunit of the vacuolar H+-ATPase (V-ATPase), implying more fundamental, developmental functions for the PRR in addition to its role in activating the local renin-angiotensin system.Results: Podocyte-specific conditional (P)RR...

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ea0029p273 | Cardiovascular Endocrinology and Lipid Metabolism | ICEECE2012

Testosterone replacement therapy: a safety audit of clinical practice including men with Type 2 diabetes and cardiovascular disease

Brooke J. , Walter D. , Muraleedharan V. , Jones T.

Hypogonadism is highly prevalent in men with type 2 diabetes (T2D) and/or cardiovascular disease (CVD). Low testosterone levels are associated with CVD risk factors including obesity, insulin resistance, dyslipidaemia and hypertension. Testosterone replacement therapy (TRT) has been shown to have beneficial effects on these parameters; however, safety needs to be verified. An audit of 308 (50% with T2D, 32.1% CVD, 82.8% ED) hypogonadal men (age 59.02±13.23 years; mean bas...

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ea0029p274 | Cardiovascular Endocrinology and Lipid Metabolism | ICEECE2012

Thyroid axis hormones and cortisol are associated with subjective fatigue in patients with coronary artery disease

Bunevicius A. , Gintauskiene V. , Brozaitiene J. , Prange A. , Bunevicius R.

Introduction: Subjective fatigue is a common symptom in patients with coronary artery disease (CAD) and has a significant negative effect on quality of life of CAD patients. However, currently there are no studies evaluating possible association between endocrine measures and subjective fatigue in CAD patients. Therefore the aim of the current study was to evaluate possible associations of subjective fatigue with function of adrenal axis and thyroid axis in CAD patients.<p...

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ea0029p275 | Cardiovascular Endocrinology and Lipid Metabolism | ICEECE2012

Familiar hypercholesterolemia: effects of treatment with rosuvastin

Gonzalez-Molero I. , Dominguez Lopez M. , Gonzalo Marin M. , Soriguer F.

Introduction and objetives: There are few data in literature about the effects of rosuvastatin in patients with familial hypercholesterolemia in Spain. The objective of this study has been:1-to evaluate the efficacy and security of rosuvastatin in patients with familiar hypercholesterolemia2-to test the hypothesis that patients with diabetes have different response to treatment with rosuvastatin.Material and ...

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ea0029p276 | Cardiovascular Endocrinology and Lipid Metabolism | ICEECE2012

Metabolic and glycaemic profile in patients with acute coronary syndrome

Maric A. , Gradiser M. , Igrec M. , Marodi I. , Katalinic D.

Introduction: Components of metabolic syndrome, particularly overweight, dyslipidemia and diabetes mellitus (DM), are well known cardiovascular risk factors. The objective of this work was to evaluate the metabolic and glycaemic profile in patients (pts) with acute coronary syndrome (ACS), treated in our institution.Methods: A total of 126 pts with ACS (unstable angina, acute myocardial infarction with /STEMI/or without ST-segment elevation/NSTEMI/) were...

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ea0029p277 | Cardiovascular Endocrinology and Lipid Metabolism | ICEECE2012

Impact of 6-month course of 1 mg finasteride tablets on levels of lipid profile in men with androgenic alopecia

Seiedmohammaddoulabi S. , Kavoussi H. , Isapour D. , Hashemian A.

Background: Atherosclerosis constitutes one of the most frequent diseases and one of the important predisposing factor for atherosclerosis is lipid profile change. Androgen change lipid profile mainly high densitylipoprotein (HDL), and 1 mg finasteride tablets are used for treating androgenic hair loss through inhibition of 5-α reductase, and preventing convertion of testosterone to dihydrotestosterone (DHT) the most active derivative of testosterone in the other hands an...

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ea0029p278 | Cardiovascular Endocrinology and Lipid Metabolism | ICEECE2012

Transient glucocorticoid excess does not cause persisting metabolic changes in mice

Auvinen H. , Romijn J. , Biermasz N. , Boon M. , Havekes L. , Smit J. , Rensen P. , Pereira A.

Introduction: In humans, Cushings syndrome (CS) is associated with an increased incidence of the metabolic syndrome, increased cardiovascular morbidity and mortality, even after long-term correction of glucocorticoid (GC) excess.Aim: To evaluate the effects of transient overexposure to GC on the metabolic changes in the long-term in mice.Methods: Single housed male C57Bl/6J mice were given corticosterone (CORT; 50 μg/ml)...

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ea0029p279 | Cardiovascular Endocrinology and Lipid Metabolism | ICEECE2012

Gastrectomy for early gastric cancer is associated with decreased cardiovascular mortality in accordance with amelioration of metabolic abnormalities, visceral adiposity and atherosclerosis

Lee Y. , Han S. , Kim H. , Hyung W. , Lim J. , Lee K. , Lee H. Lee E. , Kang E. , Ahn C. , Cha B. , Lee H.

Objectives: We investigated cardiovascular and all-cause mortality in patients who underwent gastrectomies for early gastric cancer (EGC), and analyzed the changes in metabolic parameters in these patients after surgery.Background: Bariatric surgery, including gastric banding and gastric bypass, effectively induces weight loss and resolves cardiovascular comorbidities in obese patients.Methods: 2477 patients who underwent gastrecto...

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ea0029p280 | Cardiovascular Endocrinology and Lipid Metabolism | ICEECE2012

The role of testosterone activation of liver X receptor in a human macrophage cell line and its implications for the treatment of type 2 diabetes and atherosclerosis

Kilby E. , Akhtar S. , Jones T.

Testosterone deficiency is common in men with type 2 diabetes (T2D) and cardiovascular diseases (CVD), such as atherosclerosis. Previous studies have shown that testosterone replacement improves several cardiovascular risk factors including insulin resistance, glycaemic control, cholesterol and inflammation. The mechanisms by which testosterone mediates these effects are unknown. LXR, a nuclear receptor also regulates these cardiovascular risk factors and the atheroprotective ...

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ea0029p281 | Cardiovascular Endocrinology and Lipid Metabolism | ICEECE2012

Chemerin/CMKLR1 and adiponectin/T-cadherin expression in human coronary arterial wall and pericoronary adipose tissue in correlation with atherosclerosis

Kostopoulos C. , Karamouzis I. , Spiroglou S. , Papadaki H.

Introduction: Perivascular adipose tissue has been implicated in vascular physiology and pathology, including atherosclerosis. Local adipokine production is one of the paracrine mechanisms involved in this adipose tissue fuction. We investigated the expression of adipokines chemerin and adiponectin and their receptors CMKLR1 and T-cadherin, respectively, in human coronary arterial wall and pericoronary fat as well as their correlation with coronary atherosclerosis.<p class...

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ea0029p282 | Cardiovascular Endocrinology and Lipid Metabolism | ICEECE2012

Six loci associated with high-density lipoprotein cholesterol or triglycerides in Chinese pregnant women

Nie M. , Wang Y. , Li W. , Ping F. , Gao J. , Liu J.

Background: The serum concentrations of lipoproteins and lipids are heritable risk factors for cardiovascular disease. Pregnancy is associated with increases in plasma lipid profiles. Identifying the genetic determinants could provide novel insights into mechanisms of dyslipidemia and reveal avenues for developing new therapies. The objective of this study was to investigate the impact of six single nucleotide polymorphisms (SNPs) on serum lipid levels during pregnancy.<p ...

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ea0029p283 | Cardiovascular Endocrinology and Lipid Metabolism | ICEECE2012

Development of primary hyperparathyroidism is closely associated with the onset of dyslipidemia and insulin resistance in a large family harboring a MEN1 gene mutation

Anselmo J. , Moniz C. , Sousa I. , Cesar R.

Introduction: Dyslipidemia is a common finding in patients with primary hyperparathyroidism and together with hypertension and glucose intolerance seems to be responsible by the increased risk of cardiovascular disease in hyperparathyroid patients. In the present work we studied members of a family harboring a MEN1 gene mutation (type 1 multiple endocrine neoplasia syndrome). The penetrance of primary hyperparathyroidism in this condition is close to 100%, starting usually dur...

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ea0029p284 | Cardiovascular Endocrinology and Lipid Metabolism | ICEECE2012

Level of adiponectin and vaspin, and adiponectin/vaspin ratio is associated with insulin resistance and clinical expression of metabolic syndrome in type 2 diabetic patients

Liu S. , Yang J. , Wang T. , Wang X. , Niu B.

Objective: The goal of this study is to evaluate the relationship between levels of adiponectin and vaspin, adiponectin/vaspin (A/V) ratio and metabolic syndrome, degree of adiposity, and insulin resistance (IR), as well as their correlation with metabolic variables.Methods: Two hundred sixty patients with newly diagnosed type 2 diabetes (126 male, 134 female) were enrolled. Patients were grouped based on degree of adiposity, IR assessment (homeostasis m...

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ea0029p285 | Cardiovascular Endocrinology and Lipid Metabolism | ICEECE2012

Insulin mediates the glucagon-induced decrease in atrial natriuretic peptide: a randomized controlled trial

Arafat A. , Rudovich N. , Weickert M. , Adamidou A. , Spranger J. , Birkenfeld A. , Mohlig M. , Pfeiffer A.

Objectives: Atrial natriuretic peptide (ANP) is a cardiac hormone that is known to play an essential role in regulation of blood pressure and vascular endothelial function. However, the metabolic regulation of ANP is not fully understood. In patients with the metabolic syndrome, hyperglucagonemia is a common feature, besides hypertension and hyperinsulinemia. Our aim was to evaluate the impact of glucagon on proANP and the possible mechanisms underlying this effect.<p clas...

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ea0029p286 | Cardiovascular Endocrinology and Lipid Metabolism | ICEECE2012

The role of β-arrestin proteins in CB1 cannabinoid receptor endocytosis

Hunyady L. , Gyombolai P. , Boros E. , Turu G.

Introduction: β-Arrestins are cytosolic proteins, which play key roles in the desensitization, internalization and signaling of G protein-coupled receptors. Currently, little is known about the role of β-arrestins in the internalization of the CB1 cannabinoid receptor (CB1R). Therefore, the interaction between β-arrestins and CB1R, and its role in receptor internalization were studied.Materials and methods: The β-arrestin binding of C...

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ea0029p287 | Cardiovascular Endocrinology and Lipid Metabolism | ICEECE2012

Abstract withdrawn....

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ea0029p288 | Cardiovascular Endocrinology and Lipid Metabolism | ICEECE2012

Plasma aldosterone to plasma renin ratio on an automated analyzer using two novel chemiluminescence immunoassays

Manolopoulou J. , Bennett A. , Grimminger P. , Fischer E. , Pallauf A. , Reincke M. , Diederich S. , Bidlingmaier M.

Background: Screening for primary aldosteronism (PA) using the aldosterone to renin ratio (ARR) is recommended by clinical practice guidelines in patient groups with a high prevalence as the disease is reported by several authors in more than 10% of essential hypertensives (EH).Methods: Plasma aldosterone concentration (PAC) and direct renin (DR) were measured using two novel automated chemiluminescence assays (IDS-iSYS; Boldon, UK) and compared to the S...

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ea0029p289 | Cardiovascular Endocrinology and Lipid Metabolism | ICEECE2012

Hypogonadism as a risk factor for cardiovascular mortality in men: a meta-analytic study

Rastrelli G. , Corona G. , Monami M. , Guay A. , Buvat J. , Sforza A. , Forti G. , Mannucci E. , Maggi M.

Objective: To verify whether hypogonadism represents a risk factor for cardiovascular (CV) morbidity and mortality and to verify whether testosterone replacement therapy (TRT) improves CV parameters in subjects with known CV diseases (CVDs).Design: Meta-analysis.Methods: An extensive Medline search was performed using the following words testosterone, CVD, and males. The search was restricted to data from January 1, 196...

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ea0029p290 | Cardiovascular Endocrinology and Lipid Metabolism | ICEECE2012

Testosterone and cardiovascular risk in patients with erectile dysfunction

Corona G. , Rastrelli G. , Balercia G. , Sforza A. , Forti G. , Maggi M.

Background: The relationship between cardiovascular (CV) diseases (CVD) and testosterone levels in men has not been completely clarified.Aim: To evaluate the association between testosterone levels and CV risk in subjects with erectile dysfunction (ED) and to verify whether their body mass index might (BMI) represents a possible confounder in testosterone-related CV stratification.Material and methods: A consecutive series of 2269 ...

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ea0029p291 | Cardiovascular Endocrinology and Lipid Metabolism | ICEECE2012

Oxytocin stimulates cardiomyogenesis and cardioprotection via stem cells activation

Jankowski M. , Noiseux N. , Gutkowska J.

The functional oxytocin (OT) system is present in the heart and stimulate cardiomyocyte (CM) differentiation of embryonic stem cells. Presently, we are reporting that the OT stimulates CM differentiation of stem cells isolated from the rat heart and termed as side population cells (SP). Specifically, the phenotype of SP-CD31(−) cells, but not SP-CD31(+) cells, proliferate in the presence of OT; the OT treatment promote cell aggregation, and then stimulate differentiation...

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ea0029p292 | Cardiovascular Endocrinology and Lipid Metabolism | ICEECE2012

Metabolism of angiotensin II and angiotensin III in HAC15 cells

Oki K. , Kopf P. , Campbell W. , Gomez-Sanchez E. , Gomez-Sanchez C.

Angiotensin II (A-II) stimulates aldosterone (aldo) secretion through the zona glomerulosa AT1R. A-II can be metabolized to angiotensin III (A-III) which also stimulates aldo synthesis. In the rat A-III stimulates aldo secretion through the AT2R receptor.The human adrenocortical HAC15 cells were incubated with A-II or A-III (10 nM) for 24 h and the concentration of aldo and cortisol (F) measured in the media. A-II produced a fourfold and A-III a twofold ...

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ea0029p293 | Cardiovascular Endocrinology and Lipid Metabolism | ICEECE2012

Chemerin/CMKLR1 and adiponectin/T-cadherin expression in human aortic wall and periaortic adipose tissue in correlation with atherosclerosis

Kostopoulos C. , Karamouzis I. , Spiroglou S. , Papadaki H.

Introduction: Periadventitial adipose tissue has been implicated in vascular physiology and pathology, including atherosclerosis, through paracrine and endocrine mechanisms, mainly adipokine production. We investigated the expression of adipokines chemerin and adiponectin and their receptors CMKLR1 and T-cadherin, respectively, in human aortic arterial wall and periaortic fat as well as their correlation with aortic atherosclerosis.Methods: Paraffin embe...

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ea0029p294 | Cardiovascular Endocrinology and Lipid Metabolism | ICEECE2012

In primary aldosteronism, plasma aldosterone concentration is an independent risk factor for albuminuria, and the higher baseline urinary albumin excretion predicts the less glomerular filtration rate after treatment

Iwakura Y. , Morimoto R. , Kudo M. , Ono Y. , Ito S. , Satoh F.

Background: The higher prevalence of urinary albumin was reported in patients with primary aldosteronism (PA) than those with essential hypertension (EH). It remains to be unclear, although glomerular hyperfiltration (HF) was hypothesized as one of the mechanisms of urinary albumin.Objectives: To clarify the risk factor of urinary albumin and the relationship with HF in PA.Methods: 123 patients with PA were treated acco...

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ea0029p295 | Cardiovascular Endocrinology and Lipid Metabolism | ICEECE2012

Relationships between insulin resistance and cardiovascular risk factors in primary hyperparathyroidism

Tassone F. , Baffoni C. , Gianotti L. , Pellegrino M. , Cassibba S. , Magro G. , Cesario F. , Borretta G.

Introduction: Primary hyperparathyroidism (pHPT) is characterized by an increased frequency of glucose tolerance abnormalities associated with insulin-resistance. Few studies evaluated the relationship between insulin resistance and others cardiovascular risk factors in pHPT.Subjects and methods: In 255 consecutive pHPT patients (M/F=66/189, age (mean±S.D.): 59.9±13.7 years, PTH: 215.6±219.4 pg/ml, calcium: 11.2±1.2 mg/...

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ea0029p296 | Cardiovascular Endocrinology and Lipid Metabolism | ICEECE2012

Allosteric effects between the protomers of AT1 angiotensin receptor homodimer: role of the conserved DRY motif

Szalai B. , Varnai P. , Hunyady L.

Introduction: G protein coupled receptor dimerization is proposed to have great impact on receptor signaling. Allosteric communication between the protomers of a dimer can alter ligand binding, receptor conformation and the interactions with different effector proteins. Although the concept of intradimeric interactions is widely accepted, the molecular mechanism behind them is not clearly understood. In this study we investigated the allosteric interactions within the type I a...

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ea0029p297 | Cardiovascular Endocrinology and Lipid Metabolism | ICEECE2012

Effect of triiodothyronine and angiotensin-II on expression of (pro)renin receptor in the human erythroid cell line, YN-1

Nishiyama H. , Kaneko K. , Ohba K. , Yoshioka T. , Shimizu T. , Hirose T. , Totsune K. , Takahashi K.

The reninangiotensin system is known to enhance erythropoiesis. (Pro)renin receptor ((P)RR), a specific receptor for renin and prorenin, has recently been identified. We have recently shown expression of (P)RR in a human erythroid cell line, YN-1. It is known that triiodothyronine (T3) and angiotensin-II (A-II) stimulate proliferation of erythroid cells. The aim of the present study is to clarify effects of T3 and A-II on expression of (P)RR in the ...

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ea0029p298 | Cardiovascular Endocrinology and Lipid Metabolism | ICEECE2012

The combined use of serum interleukin 6 and C-reactive protein is better than either alone in predicting cardiovascular events in a Chinese population

Lam K. , Chow W. , Yeung C. , Tso A. , Yuen M. , Fong C. , Wat N. , Lam T. , Lo S. , Tse H. , Cheung B.

Objectives: Obesity is associated with an increase in cardiovascular risk. We investigated whether the measurement of obesity-related biomarkers could enhance the prediction of cardiovascular (CVD) events when used in conjunction with traditional risk factors.Methods: We studied subjects in the Hong Kong Cardiovascular Risk Factors Prevalence Study 2 (CRISPS 2) cohort without previous cardiovascular disease. Baseline serum levels of several biomarkers kn...

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ea0029p299 | Cardiovascular Endocrinology and Lipid Metabolism | ICEECE2012

Short-term detraining cannot reverse insulin sensitivity improvement and serum retinol binding protein 4 in spontaneously hypertensive rats previously submitted to aerobic exercise

Lehnen A. , Pinto G. , Borges J. , Markoski M. , Schaan B.

Background: Elevated serum retinol binding protein 4 (RBP4) levels were previously described in insulin-resistance states. Recently it was shown that RBP4 contributes, at least partly, to the pathogenesis of insulin resistance in spontaneously hypertensive rats (SHR), but the effects of exercise training and time-course of changes after detraining on RBP4 levels have not yet been explored.Aims: To examine the effects of exercise training and short-term d...

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ea0029p300 | Cardiovascular Endocrinology and Lipid Metabolism | ICEECE2012

Multiple cardiovascular risk factors in patients with myotonic dystrophy type 1 and 2

Passeri E. , Bugiardini E. , Sansone V. , Costa E. , Bandera F. , Pizzocaro A. , Meola G. , Ambrosi B. , Corbetta S.

Introduction: Myotonic dystrophy (DM) type 1 and 2 are multisystemic autosomal dominant disorders with visceral obesity, insulin resistance and hypogonadism. The prevalence of metabolic risk factors for coronary artery disease (CAD) in DM is not well defined, particularly in patients affected by DM2, a milder and clinical challenging condition.Methods: We assessed the frequency of CAD risk factors in 31 male DM1 (44±11 years) and 13 male DM2 (54&#17...

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ea0029p301 | Cardiovascular Endocrinology and Lipid Metabolism | ICEECE2012

Role of peroxisome proliferator-activated receptor-γ (PPARγ) in regulation of glucocorticoid metabolism in vascular smooth muscle cells

Pacha J. , Vagnerova K. , Ergang P. , Loukotova J.

Glucocorticoids are known to have significant and diverse effects on the cardiovascular system. They have been shown to foster hypertension indirectly due to enhanced vascular tone by potentiation of the vasocontrictor hormones and directly by action on vascular smooth muscle cells (VSMC). The local concentration of glucocorticoids in various tissue including vessels is determined by the enzyme 11β-hydroxysteroid dehydrogenase type two (11HSD2) and 1 (11HSD1) that has bee...

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ea0029p302 | Cardiovascular Endocrinology and Lipid Metabolism | ICEECE2012

Recombinant erythropoietin treatment enhances mitochondrial function in human skeletal muscle

Plenge U. , Guadeloupe-Grau A. , Andersen P. , Carsten L. , Dela F. , Pott F. , Jorn H. , Belhage B. , Boushel R.

Erythropoietin (Epo) treatment has been shown to induce mitochondrial biogenesis in cardiac muscle along with enhanced mitochondrial capacity in mice. We hypothesized that recombinant human Epo (rhEpo) treatment enhances skeletal muscle mitochondrial oxidative phosphorylation (OXPHOS) capacity in humans. In six healthy volunteers rhEpo was administered by s.c. injection over eight weeks with oral iron (100 mg) supplementation taken daily. Mitochondrial OXPHOS was quantified by...

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ea0029p303 | Cardiovascular Endocrinology and Lipid Metabolism | ICEECE2012

Association of IL4 receptor gene polymorphisms with high density lipoprotein cholesterol

Shiau M. , Huang C. , Chang Y.

Abundant evidence demonstrates that long-term cytokine-mediated inflammation is a risk factor for obesity and type 2 diabetes mellitus (T2DM). Our previous study shows a significant association between IL4 genotypes and T2DM, as well as between IL4 genotypes and the lower circulatory levels of high-density lipoprotein-cholesterol (HDL-C). In addition, IL4 has anti-hyperglycemic function by improving insulin sensitivity and glucose tolerance as well as being involved in lipid m...

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ea0029p304 | Cardiovascular Endocrinology and Lipid Metabolism | ICEECE2012

Cardiovascular risk factors in a large cohort of children with GH deficiency

De Martino L. , Capalbo D. , Esposito A. , Cerbone M. , Improda N. , Rezzuto M. , Salerno M.

Background: Adults with GH deficiency (GHD) may have an increased risk of cardiovascular disease. Several studies showed that also GHD children may present cardiovascular risk factors. However results are controversial.Objective: Aim of this prospective, case-control study on a large cohort of children with GHD was to evaluate the effects of GHD and GH therapy on cardiovascular risk factors, such as lipid profile, clinical measures of visceral adiposity ...

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ea0029p305 | Cardiovascular Endocrinology and Lipid Metabolism | ICEECE2012

Lipid profile in children with persistent idiopathic subclinical hypothyroidism

De Martino L. , Cerbone M. , Barbieri F. , Esposito A. , Di Donato I. , Di Mase R. , Salerno M.

Background: There is a great controversy on whether subclinical hypothyroidism (SH) in children should be treated for TSH values between 4.5 and 10 mU/l. In adults SH has been associated with abnormalities in lipid profile and increased risk of atherosclerosis. Data in untreated SH children are scanty.Objective: The aim of this cross-sectional controlled study was to evaluate in children the effects of long term untreated SH on lipid profile and endothel...

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ea0029p306 | Cardiovascular Endocrinology and Lipid Metabolism | ICEECE2012

Variants of endothelial nitric oxide synthase gene are associated with components of metabolic syndrome in an Arab population

Alkharfy K. , Al-Daghri N. , Al-Attas O. , Alokail M. , Mohammed A. , Vinodson B. , Clerici M. , Kazmi U. , Hussain T. , Draz H.

Genetics plays a crucial role in the development of metabolic syndrome (MetS). Here we examined the association between endothelial nitric oxide synthase (eNOS) gene polymorphisms and MetS in a Saudi Arabian cohort to extend the understanding of the genetic basis of MetS in diverse ethnic populations. Anthropometric, clinical and biochemical parameters as well as genotyping for 894G>T, −786T>C variants of eNOS gene by PCRRFLP and 4a/b by direct PCR were per...

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ea0029p307 | Cardiovascular Endocrinology and Lipid Metabolism | ICEECE2012

MRTF-A, a rho-dependent co-activator of SRF, regulates phenotypic modulation of vascular smooth muscle cells and plays an important role in vascular remodeling

Kuwahara K. , Minami T. , Shibata J. , Yamada C. , Kuwabara Y. , Nakao K. Kinoshita H. , Usami S. , Nakagawa Y. , Nishikimi T. , Nakao K.

Myocardin-related transcription factor (MRTF)-A is a Rho signaling-responsive co-activator of serum response factor (SRF). In this study we investigated roles of MRTF-A in the process underlying vascular diseases by using two different mouse models of vascular diseases. MRTF-A expression was significantly higher in the wire-injured femoral arteries of wild-type mice and in the atherosclerotic aortic tissues of ApoE−/− mice than in healthy control tissues...

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ea0029p308 | Cardiovascular Endocrinology and Lipid Metabolism | ICEECE2012

Association of PON-1 activity and other anti-oxidative enzymes with long-chain fatty acids profile in T2DM

Rasic-Milutinovic Z. , Tica J. , Gluvic Z. , Popovic-Radinovic V. , Vujovic M. , Lackovic M. , Samardzic V. , Popovic T. , Glibetic M.

Background: Serum paraoxonase-1 (PON-1) activity is decreased in clinical conditions associated with low high density-cholesterol (HDL-C), increased lipid peroxidation and low-grade chronic inflammation such as in type 2 diabetes mellitus (T2DM). Although many studies have shown that some poly unsaturated fatty acids (PUFA) modulate cardiovascular risk in T2DM, until now there is no data about the association of any fatty acid (FA) with PON-1 activity. This study aims to inves...

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ea0029p309 | Cardiovascular Endocrinology and Lipid Metabolism | ICEECE2012

Risk factors of metabolic syndrome in adolescent with classical congenital adrenal hyperplasia

Esposito A. , De Martino L. , Improda N. , Capalbo D. , Di Mase R. , Di Donato I. , Salerno M.

Background: Patients with classical congenital adrenal hyperplasia (CAH) require life-long therapy with glucocorticoids in order to suppress the androgen production through the inhibition of CRH and consequently ACTH. The therapy must be balanced to avoid either iatrogen hypercortisolism or hyperandrogenism both potentially associated with adverse cardiovascular risk profile.Objective: Aim of this cross-sectional controlled study was to investigate the m...

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ea0029p310 | Cardiovascular Endocrinology and Lipid Metabolism | ICEECE2012

Alterations of protein expression profiles in 3T3-L1 adipocytes by interleukin 4

Chang Y. , Chen S. , Chiu Y. , Tsao C. , Shiau M.

Obesity, characterized by excess intra-abdominal adipose tissue, is closely associated with a cluster of metabolic disorders such as type 2 diabetes mellitus (T2DM). Our previous study revealed significant associations between interleukin 4 (IL4) genotypes and T2DM, as well as IL4 genotypes and high density lipoprotein-cholesterol levels. Our most recent study results reveal that IL4 has anti-hyperglycemic function by improving insulin sensitivity and glucose tolerance. In add...

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ea0029p311 | Cardiovascular Endocrinology and Lipid Metabolism | ICEECE2012

Anti-Müllerian hormone may be a hormonal regulator of the cardiovascular system

Dennis N. , Jones G. , van Rij A. , McLennan I.

Anti-Müllerian hormone (AMH, Müllerian inhibiting substance) is a protein hormone expressed by the Sertoli cells of the testes and the granulosa cells of the ovaries. AMH is best known for its paracrine functions in reproductive organ development and function. The hormonal roles of AMH are largely unexplored, but functions are emerging in growth and brain development. To date, there is no putative function for AMH in the blood of adults. AMH belongs to the TGF-β...

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ea0029p312 | Cardiovascular Endocrinology and Lipid Metabolism | ICEECE2012

Anti-oxidataive actions of urocortin on HL-1 cardiomyocytes

Ikeda K. , Fujioka K. , Claycomb W. , Manome Y. , Tojo K.

Cardioprotective actions of urocortin (Ucn) I have been proposed by several studies and may play a critical role on stress adaptation. And one of the beneficial actions on cardiovascular cells may be anti-oxidative actions. In addition, Ucn I may be regulated by oxidative stress, therefore, the present study is designed to reveal anti-oxidative actions of Ucns on cardiomyocytes. Mouse atrial cell line, HL-1 cardiomyocytes, was cultured in standard Claycomb medium supplemented ...

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ea0029p313 | Cardiovascular Endocrinology and Lipid Metabolism | ICEECE2012

Adipokine expression profile in pericoronary and periaortic adipose tissue in correlation with coronary and aortic atherosclerosis

Karamouzis I. , Spiroglou S. , Kostopoulos C. , Papadaki H. , Varakis J.

Introduction: Adipose tissue is a source of peptides with paracrine and endocrine actions, called adipokines. Adipokines produced by periadventitial fat have been implicated in vascular pathology, including atherosclerosis. We investigated the expression of novel adipokines chemerin and vaspin, as well as visfatin, apelin and adiponectin in human pericoronary and periaortic fat in correlation with coronary and aortic atherosclerosis.Methods: Paraffin emb...

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ea0029p314 | Cardiovascular Endocrinology and Lipid Metabolism | ICEECE2012

Fatty liver index and lipid accumulation product index as markers of liver steatosis in premenopausal women with nonalcoholic fatty liver disease

Vassilatou E. , Vassiliadi D. , Lazaridou H. , Betsi G. , Pavlaki A. , Kelekis N. , Hadjidakis D. , Dimitriadis G.

Background: Nonalcoholic fatty liver disease (NAFLD) is an increasingly recognised disorder with an estimated prevalence of 2030% in the general population and is considered as the hepatic manifestation of the metabolic syndrome. Fatty liver index (FLI) has been developed as an indicator of hepatic steatosis (HS). Another marker, the lipid accumulation product (LAP) index, initially developed to assess cardiovascular risk, has been recently shown to be a reliable marker ...

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ea0029p315 | Cardiovascular Endocrinology and Lipid Metabolism | ICEECE2012

Effects of long-term treatment of hypogonadal men with testosterone undecanoate on blood pressure, fasting glucose, HbA1c and C-reactive protein

Saad F. , Haider A. , Gooren L.

Introduction: Hypogonadism is associated with metabolic syndrome and all its individual components. This study analysed effects of normalization of serum testosterone in mainly elderly, hypogonadal men.Methods: Prospective registry study of 252 men (mean age 60.6±8.0 years), with testosterone levels between ≤3.5 ng/ml. They received parenteral testosterone undecanoate 1000 mg at day 1, week 6 and every 12 weeks thereafter for up to 66 months.<...

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ea0029p316 | Cardiovascular Endocrinology and Lipid Metabolism | ICEECE2012

Dysregulation of tissue renin–angiotensin–aldosterone system in obese hypertensive rats

Takeda Y. , Cheng Y. , Demura M. , Yoneda T. , Kometani M. , Sawamura T. , Karashima S.

The activation of local reninangiotensinaldosterone system (RAAS) plays a pivotal role in the overall pathophysiology of the cardiovascular and renal diseases. Aldosterone can activate local renin and angiotensin converting enzyme (ACE). However, the effects of blockade of aldosterone on tissue RAAS including (pro)renin receptor and ACE2 are unclear in obese hypertensive rats induced by high-salt diet. Obese Zucker rats (ZOR) were fed with normal or high-salt diet ...

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ea0029p317 | Cardiovascular Endocrinology and Lipid Metabolism | ICEECE2012

The relationship between 25(OH)D levels and markers of atherosclerosis and inflammation in type 2 diabetic patients

Akalin A. , Karakus A. , Urfali F.

Vitamin D deficiency has a leading role in endothelial functions and pathogenesis of type two diabetes and is supposed to take part in atherosclerosis. In this study we aimed to investigate the correlation between markers of atherosclerosis and inflammation with 25(OH)D levels in patients with type two diabetes. Forty patients with type two diabetes and macrovascular complication and 40 patients without macrovascular complication were included in the study. Thirty healthy subj...

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ea0029p318 | Cardiovascular Endocrinology and Lipid Metabolism | ICEECE2012

Plasma total homocysteine levels in transsexuals after cross-sex hormonal treatment

Becerra A. , Perez-Lopez G. , Menacho M. , Villar R. , Del Rey J. , Lucio M. , Asenjo N. , Rodriguez-Molina J. , Llopis J. , Aguilar V.

Introduction: The transsexuals are persons that having born with a biological sex feel to belong to the opposite sex. To obtain the sexual characters opposite to his (her) biological sex they need treatment with cross-sex hormones.This treatment with sexual steroids can produce changes in cardiovascular risk factors (CRF). There has been described that hyperhomocysteinemia is an independent CRF that is modifiable by cross-sex hormonal treatment (CHT) in ...

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ea0029p319 | Cardiovascular Endocrinology and Lipid Metabolism | ICEECE2012

Body composition and association to NT-proBNP and myostatin levels in heart failure patients

Christensen H. , Kistorp C. , Schou M. , Zerahn B. , Keller N. , Faber J.

Objectivs: Plasma NT-proBNP is inversely associated with BMI in patients with heart failure (HF). A possible mechanism may be the lipolytic effect of natriuretic peptides on abdominal fat.Myostatin is previously described as a negative regulator of skeletal muscle mass in cachexia.We assessed the hypothesis that body composition is related to plasma NT-proBNP and that myostatin levels are associated with loss of fat free mass (FFM)...

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ea0029p320 | Cardiovascular Endocrinology and Lipid Metabolism | ICEECE2012

Subclinical atherosclerosis and arterial stiffness are associated with levels of circulating androgens in healthy recently menopausal women

Armeni E. , Stamatelopoulos K. , Creatsa M. , Rizos D. , Georgiopoulos G. , Kazani M. , Alexandrou A. , Dendrinos S. , Augoulea A. , Papamichael C. , Lambrinoudaki I.

Introduction: Endogenous sex hormones may affect the cardiovascular risk profile in postmenopausal women indirectly by inducing metabolic, hemodynamic and immunological changes as well as directly through steroid receptors on the arterial wall. The results however, remain controversial.Objectives: This cross-sectional study aims to examine associations between circulating sex hormone levels and indices of vascular function and structure.<p class="abs...

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ea0029p321 | Cardiovascular Endocrinology and Lipid Metabolism | ICEECE2012

Metabolic syndrome, hormone levels and inflammation in patients with erectile dysfunction

Suleiman-Martos Y. , Arrabal-Polo M. , Jimenez-Pacheco A. , Zuluaga-Gomez A. , Escobar-Jimenez F. , Arrabal-Martin M.

Introduction: Chronic inflammation has been found to play an important role in the development of cardiovascular risk factors and erectile dysfunction (ED). Metabolic syndrome (MS) is associated with endothelial dysfunction and higher cardiovascular risk. The end point of this study was to investigate the prevalence of metabolic syndrome in patients with ED in comparison with control subjects and to analyse the association with acute phase reactants (CRP, ESR) and hormone leve...

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ea0029p322 | Cardiovascular Endocrinology and Lipid Metabolism | ICEECE2012

Duration effect of statin therapy on bone metabolism in dyslipidemic patients

Cvijanovic O. , Crncevic-Orlic Z. , Bicanic N. , Celic T. , Bobinac D. , Klobucar S.

Statins are cholesterol-lowering drugs decreasing bone resorption by inhibition of the farnesyl diphosphate synthase step in the mevalonic acid pathway and therefore are believed to have beneficial effects on bone status. Objective is to examine the relationship between lipid status and duration of statin therapy on the bone metabolism in dyslipidemic patients. A hundred and sixty subjects were divided into five groups depending on duration of statin therapy: (controls 0 years...

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ea0029p323 | Cardiovascular Endocrinology and Lipid Metabolism | ICEECE2012

Coronary flow reserve is inversely related to urinary cortisol in Cushing’s syndrome

Fallo F. , Capizzi D. , Dassie F. , Sonino N. , Martini C. , Paoletta A. , Famoso G. , Iliceto S. , Tona F.

There is evidence for a strong association between Cushings syndrome, characterized by a cluster of systemic complications, and increased cardiovascular risk. To our knowledge, coronary circulatory function has not been explored in Cushings syndrome. The aim of the study was to evaluate coronary flow reserve (CFR), an index of coronary microvascular function, in patients with Cushings syndrome. Thirteen newly diagnosed patients with Cushings syndrome (1...

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ea0029p324 | Cardiovascular Endocrinology and Lipid Metabolism | ICEECE2012

Myeloperoxidase is not associated with applications of coronary artery disease and type 2 diabetic patients

Mokhort T. , Tsapaeva N. , Buko I. , Konstantinova E. , Shyshko O.

Myeloperoxidase (MPO), an enzyme of the innate immune system, exhibits pro-atherogenic effects and includes influence on oxidative damage to LDL- and HDL-cholesterol, and promotion of endothelial dysfunction.The aim: To investigate the disturbance of MPO in type 2 diabetic (T2D) patients depending on intensity of atherosclerosisMaterial and methods: We investigated 244 patients aged from 45 to 60 years (M±SD 54.0±4.63) in...

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ea0029p325 | Cardiovascular Endocrinology and Lipid Metabolism | ICEECE2012

Analysis of hyponatremia in a tertiary hospital during a 5 year period

Duran A. , Gomez E. , Molino A. , Granda C. , Marco J.

Aims: Hiponatremia is the most frequent electrolyte disturbance. Our aim is to retrospectively analyze the diagnosis of hyponatremia in the discharge sheets of a tertiary hospital during 5 yearsMethod: Data from the MBDS (Minimum Basic Data Set) of the discharged patients from the Hospital Clínico San Carlos (Madrid) between the years 2005 and 2009 was analysed. The 5th Edition of the ICD-9-CM was used for the codification of the diagnoses and proce...

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ea0029p326 | Cardiovascular Endocrinology and Lipid Metabolism | ICEECE2012

Effect of melatonin supplementation on lipid peroxidation and on the enzymes of antioxidative system in patients with chronic coronary artery disease.

Podgajny Z. , Kot M. , Szalus N. , Mitura P. , Kaminski G.

Background: Melatonin as strong antioxidant and free radical scavenger can play important, protective role in disease in which oxidative damage is a significant component e.g.: in coronary heart disease, neoplastic disease, neurodegenerative disease. The aim of our study was determination of the effect of melatonin supplementation on malonyldialdehyde (MDA) concentration and activity of: superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and catalase (CAT) in patients...

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ea0029p327 | Cardiovascular Endocrinology and Lipid Metabolism | ICEECE2012

N-terminal pro-brain natriuretic peptide (NT-proBNP) in patients with non-ST-elevation myocardial infarction (NSTEMI) compared to patients with unstable angina (UA) in a lot of patients admitted for non-ST-elevation acute coronary syndrome (NSTE-ACS)

Pascu A. , Radoi M. , Bisoc A. , Barbu D. , Barbu I. , Ciurea C. , Totoianu G. , Stanciu M.

Introduction: The study aimed to evaluate the differences in secretion of NT-proBNP and cardiac troponin T (cTnT), in patients with NSTE-ACS for the early detection of myocardial ischemia in NSTE-ACS.Methods: Hundred and sixteen patients admitted for non-ST-elevation ACS (NSTE-ACS), 71(61.2%) men, mean age 68.7±10.2 were prospectively investigated. Plasma NT-proBNP and cTnT were measured by electrochemiluminescence (Elecsys/Cobas e, Roche Diagnostic...

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ea0029p328 | Cardiovascular Endocrinology and Lipid Metabolism | ICEECE2012

Effect of medical therapy on 24-h blood pressure profile in acromegaly

Sardella C. , Nuzzo A. , Urbani C. , Lombardi M. , Scattina I. , Tomisti L. , Martino E. , Bogazzi F.

To investigate the blood pressure profile (BP) in active acromegaly and the effect of medical treatment of acromegaly on BP circadian rhythm, we studied 21 acromegalics before and after 360 months of treatment with somatostatin analogs (15/21) or pegvisomant (5/21) or both (5/21). Ambulatory 24-h BP was recorded. The 24-h mean BP (MBP), the mean systolic BP (SBP) and diastolic BP (DBP), the day-time (day) and night-time (night) MBP, SBP and DBP and the 24-h mean heart ra...

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ea0029p329 | Cardiovascular Endocrinology and Lipid Metabolism | ICEECE2012

Polycystic ovary syndrome induces leukocyte/endothelial cell interactions

Victor V. , Banuls C. , Bellod L. , Rovira S. , Gomez M. , Rocha M. , Mijares AHernandez-

Insulin resistance is a feature of polycystic ovary syndrome (PCOS) and is related to mitochondrial and endothelial function.We tested whether hyperandrogenic insulin-resistant women with PCOS, who have an increased risk of vascular disease, display impaired leukocyte-endothelium interactions, and mitochondrial dysfunction. This was a prospective controlled study conducted in an academic medical center.The study population consisted of 43 lean reproducti...

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ea0029p330 | Cardiovascular Endocrinology and Lipid Metabolism | ICEECE2012

Effect of weight loss on C3 and C4 components of complement in obesity

Victor V. , Banuls C. , Bellod L. , Jover A. , Morillas C. , Falcon R. , Rocha M. , Mijares AHernandez-

Circulating C3 levels are elevated in obese patients, but how this factor is affected after weight loss through diet is a question that is yet unanswered. Therefore, the aim of this study was to evaluate the effects of weight loss on lipid and hydrocarbonated metabolism parameters and on the levels of C3 and C4 components of complement in obese patients. This is a longitudinal intervention study based on a 6 week very low calorie diet (VLCD), a liquid formula of 603 kcal/day. ...

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ea0029p331 | Cardiovascular Endocrinology and Lipid Metabolism | ICEECE2012

Vitamin D serum levels and cardiovascular risk factors in postmenopausal women

Bohdanowicz-Pawlak A. , Milewicz A. , Jedrzejuk D. , Szymczak J. , Arkowska A.

Results of several clinical studies have suggested that there is an excess risk of cardiovascular disease in persons with vitamin D deficiency.We examined association between serum levels of vitamin D - 25(OH)D and select cardiovascular risk factors in 254 postmenopausal women at a mean age of 55.38±205 years.Vitamin D levels, lipoproteins, TNF-α, Interleukin 6, adiponectin, insulin (using RIA methods) and glucose were as...

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ea0029p332 | Cardiovascular Endocrinology and Lipid Metabolism | ICEECE2012

Sympathetic over-activity and low adrenocortical responses to hypoglycemia in patients in early stage of hypertension

Penesova A. , Radikova Z. , Cizmarova E. , Kvetnansky R. , Vlcek M. , Imrich R.

Increased activity of sympathetic nervous system (SNS) was observed in early stage of hypertension onset. The aim of our present study was to estimate catecholamines response to stress stimulus (insulin induced hypoglycaemia) in young males with early diagnosed non-treated hypertension grade 1 (HT) and normotensive controls (NT).Methods: Insulin tolerance test (ITT, 0.1 IU/kg body weight, Actrapid HM, i.v.) was performed in 21 HT male subjects aged 20.0&...

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ea0029p333 | Cardiovascular Endocrinology and Lipid Metabolism | ICEECE2012

The effect of thyroxine replacement on reduction of small dense low-density lipoprotein (sdLDL) in patients with primary hypothyroidism.

Saito J. , Watanabe T. , Matsuzawa Y. , Omura M. , Nishikawa T.

Background: Dyslipidemia is a well-known manifestation of thyroid dysfunction and there is evidence of an association between hypothyroidism and coronary heart disease. Recently, small dense low-density lipoprotein (sdLDL) has been linked with development of cardiovascular disease. But relations between thyroid function and sdLDL remain incompletely understood.Objective: Our objective was to determine whether replacement therapy with thyroxine for patien...

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ea0029p334 | Cardiovascular Endocrinology and Lipid Metabolism | ICEECE2012

Metabolic consequences of obesity in children and adolescents

Gherlan I. , Giurcaneanu M. , Perhaita C. , Alexiu F. , Caragheorgheopol A. , Dumitrescu C. , Procopiuc C.

Introduction: The prevalence of obesity in children and adolescents has dramatically increased over the last 2030 years.Childhood overweight is associated with higher risk of obesity into adulthood and a higher incidence of metabolic consequences.Objectives: To identify the prevalence of metabolic complications in obese children and adolescents.Methods: One thirty-two obese children and adolescents (age...

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ea0029p335 | Cardiovascular Endocrinology and Lipid Metabolism | ICEECE2012

Study on the DHEA-S secretion dynamics in elderly pacients with cardiovascular diseases

Trasca D. , Popescu M. , Trasca E. , Popescu A. , Bistriceanu M. , Micu S. Tudorica-

Background: The general population trend shows an increase in the elderly. The most affected systems in the aging process are the endocrine and cardiovascular systems. The cardiovascular conditions are very important among the diseases of the elderly, the mortality due to cardiovascular diseases holding the first place in geriatrics.The aim of the study is to determine the peculiar aspect of dehydroepiandrosterone sulfate secretion dynamics in the elderl...

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ea0029p336 | Cardiovascular Endocrinology and Lipid Metabolism | ICEECE2012

Testosterone and androstane-3α, 17β-diol glucuronide correlate with coronary disease

Levalle O. , Hershson A. , Otero P. , Mormandi E. , Kogovsek N. , Aszpis S.

The relationship between endogenous testosterone concentrations and coronary disease in men is controversial. Recently, it was demonstrated that the glucuronide metabolite of dihydrotestosterone (DHT), androstane-3α, 17β-diol (3-DIOL-G), but not testosterone (T), is strongly associated to several metabolic risk factors (fat mass, insulin, HOMA index, HDL, triglycerides, ApoA1, etc.) in young and elderly men. The object of the present trial was to evaluate the plasma ...

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ea0029p337 | Cardiovascular Endocrinology and Lipid Metabolism | ICEECE2012

Cardiovascular function and IGF1 deficit (IGF1-D) in β-thalassemia major

Atzori V. , Pigliaru F. , Vacquer S. , Carta M. , Spiga A. , Bina P. , Pili M. , Manca M. , Lai M. , Mariotti S.

Introduction: Both GH and IGF1 have important effects on the heart mass and contractility and deficiency of either hormone is associated with increased cardiovascular morbidity and mortality. GH/IGF1 axis abnormalities (mostly primary or secondary IGF1-D) are frequent in adult patients with β-thalassemia major (β-Thal). IGF1-D could therefore contribute with iron overload to the hearts damage of β-Thal patients, but this question has been little investigat...

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ea0029p338 | Cardiovascular Endocrinology and Lipid Metabolism | ICEECE2012

Psoriasis is associated with decreased adiponectin levels beyond cardiovascular and metabolic risk factors

Li R. , Krishnamoorthy P. , Yu Y. , Raper A. , Baer A. , Derohannessian S. , Wilcox M. , Vorohees A. , Reilly M. , Rader D. , Gelfand J. , Mehta N.

Introduction: Psoriasis is a systemic inflammatory skin disease, which is associated with increased cardiovascular disease (CVD) potentially through metabolic derangements due to chronic inflammation. Serum adiponectin appears to decrease the risk of CVD and has been shown to negatively associate with waist size and insulin resistance (IR), both of which are increased in psoriasis. It is unknown, however, if psoriasis is associated with decreased adiponectin levels beyond trad...

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ea0029p339 | Cardiovascular Endocrinology and Lipid Metabolism | ICEECE2012

The importance of HDL cholesterol to predict adiponectin and retinol binding protein 4 concentration after one session resistance exercise

Mansouri M. , Ranjbar S. Hasani- , Keshtkar A. , Heshmat R. , Larijani B.

Introduction: The capability of exercise to induce useful effect on cardiovascular health could be partly attributed to its concomitant effect on adipokines and HDL cholesterol. Little information is available on whether post exercise concentration of these adipokines could be influenced by HDL cholesterol. Thus this study was designed to examine the possible independent effect of HDL cholesterol on serum level of adiponectin and retinol binding protein 4 following one session...

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ea0029p340 | Cardiovascular Endocrinology and Lipid Metabolism | ICEECE2012

Intrinsic myocardial disease in adults with GH deficiency is characterised by subclinical left ventricular longitudinal dysfunction revealed by tissue Doppler

Badiu C. , Mihaila S. , Mincu R. , Dulgheru R. , Jercalau S. , Vinereanu D.

Purpose: GH deficiency (GHD) is associated with increased cardiovascular events, however, the detailed mechanisms have not been assessed yet extensively. We set up this study in order to evaluate cardiac, arterial, and endothelial function, by conventional echo, TDI, and biomarkers (proBNP and troponin I), in GHD patients by comparison with normal individuals with similar cardiovascular risk factors profile.Methods: Thirty GHD patients (46±14 years,...

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ea0029p341 | Cardiovascular Endocrinology and Lipid Metabolism | ICEECE2012

Paraoxonase, malondialdehyde and lipids in subjects with asymptomatic gallstones

Atamer A. , Can A. , Ovunc AKurdas , Yesil A. , Atamer Y.

Aim: Gallstones are associated with excess body fat. Our aim was to evaluate lipid levels and markers of oxidative stress in subjects with asymptomatic gallstones.Material and method: Eighty subjects (55 females, 25 males) with a mean age±S.D. of 51±14 years with asymptomatic gallstones were admitted to the study. Forty subjects (25 females, 15 males) with a mean age±S.D. of 57±12 years (P<0....

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ea0029p341.1 | Cardiovascular Endocrinology and Lipid Metabolism | ICEECE2012

Cardiac hormones are dual inhibitors of vascular endothelial growth factor and the VEGFR2 receptor

Nguyen J P , Frost C D , Lane M L , Skelton W P , Skelton M , Vesely D L

Introduction: The growth of human tumors depends on the formation of new blood vessels and vascular endothelial growth factor (VEGF) helps control this process via inducing new capillaries to sprout from pre-existing blood vessels. Four cardiac hormones which eliminate up to 80% of human pancreatic cancers and up to 86% of human small-cell lung cancers growing in mice were investigated for their effects on VEGF and the VEGFR2/KDR/Flk-1 receptor. The VEGFR2 receptor is the main...

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15th International & 14th European Congress of Endocrinology

BiosciAbstracts