Endocrine Abstracts

Introduction: Accumulating evidence suggests an association of vitamin D with insulin resistance (IR) in women with polycystic ovary syndrome (PCOS). The role of PTH in insulin metabolism is less clear. We aim to study the association of PTH and 25-hydroxyvitamin D (25(OH)D) levels with metabolic and endocrine parameters in a cohort of PCOS women.Methods: We measured PTH and 25(OH)D levels in 544 PCOS and 139 healthy control women within the same age ran...

Introduction: Calcium transport is regulated by active transcellular and passive paracellular pathways which are responsible for calcium (re)absorption in the intestine and kidney. The activity of passive transport is determined by the permeability of tight junction. In general, the permeability of tight junction is inversely proportional with the expression of tight junction genes. Claudin and occludin among the tight junction genes are concerned directly with permeability of...

IGF1 concentrations have been reported to increase with 25-hydroxyvitamin D (25(OH)D) values in population studies, but it is unclear whether this association expresses a cause-effect relationship. Mice genetically deficient of steroid receptor coactivator 3, a transcriptional coactivator for the nuclear vitamin D receptor, have significantly lower circulating IGF1 levels than wild-types.We measured serum fasting 25(OH)D and IGF1 by enzyme- and radioimmu...

Background: Vitamin D deficiency is an important public health problem because of its great impact on bone metabolism and the possible implication in cardiovascular outcomes, diabetes, cancer and mortality. Cross-sectional studies have related vitamin D deficiency with the prevalence of diabetes but there are only a few prospective cohort studies on the incidence of type 2 diabetes.Objective: To investigate the relationship between levels of 25-hydroxyvi...

Introduction: Placenta has many essential roles to maintain pregnancy and homeostasis. Calcium transport and its regulation are also important for vital roles of placenta. In general, calcium transport is regulated by active transcellular and passive paracellular pathways. Transient receptor potential cation channel subfamily V member 5/6 (TRPV5/6), calbindin-D9k (CaBP-9k), calbindin-D28k (CaBP-28k), and Na+/Ca2+ exchanger (NCX1) are involved in the transcellular pathway. Para...

Introduction: The combination of hypokalemia and hypercalcaemia is uncommon but potentially lethal. In primary hyperparthyroidism hypokalaemia most commonly occurs due to incomplete distal renal tubular acidosis. We present the first case of simultaneous primary hyperparathyroidism with Gitelman’s syndrome resulting in profound electrolyte imbalance.Case: A 48-year old man, referred with hypokalaemia (2.5 mmol/l) presented with a short history of ex...

Introduction: In addition to its well known effects on calcium homeostasis and bone metabolism, growing evidences shows that vitamin D plays an important role in regulation of cancer angiogenesis, cell apoptosis, differentiation, and proliferation. Vitamin D acts through vitamin D receptor (VDR), an intracellular nuclear receptor. It was found an association between different cancer histotypes and single nucleotide polymorphisms (SNPs) of VDR. Despite the close relationship be...

Introduction: Here, we present a case of epithelial breast cancer releasing iPTH thereby causing MAH.Case report: A 48-year-old woman with metastatic breast cancer was consulted for hypercalcemia. Previous medical record was insignificant except for nephrolitiasis. She had a left mastectomy+left axillary lymph node dissection in another hospital. Prior to surgery no calcium levels were obtained. Pathology revealed infiltrative ductal carcinoma. Postopera...

Studies show conflicting results regarding possible excess risk of atypical fractures associated with bisphosphonate (BSP) use. Since BSP reduces bone remodeling, they freeze the skeleton allowing accumulation of microcracks over time leading to atypical fractures. We present two cases of atypical fracture and discuss on monitoring therapy and drug holiday in chronic BSP users.Methods: Over the period of last 8 months we diagnosed two cases of alendronat...

Introduction and objective: The aim of this study has been to evaluate the relationship between vitamin D and iPTH levels and the status of carbohydrate metabolism in a representative sample of the Spanish population.Material and methods: The study was conducted in two population of northern and southern Spain, evaluated in the same period of time and with a similar methodology: Pizarra Study (Málaga) and Asturias Study. Subjects in both groups unde...

Introduction: We report a case of a parathyroid carcinoma with very unusual and revealing features.Case report: DAB, male aged 66 was subjected to subtotal gastrectomy because of a localized gastric adenocarcinoma (intestinal type). A mild primary hyperparathyroidism (PTH<200 pg/ml) was simultaneously found. Calcium oxalate nephrolythiasis at 50 years was noted. Sonography revealed a nodular lesion in the right lower thyroid pole, while NMR showed a ...

Introduction: Pseudohypoparathyroidism type la (PHP-1a) is an uncommon disorder that results from an inactivating mutation in the GNAS gene. It can present with resistance to several hormones, in addition to parathyroid hormone (PTH). A characteristic skeletal phenotype also results, referred to as Albright’s hereditary osteodystrophy, that occurs because of the crucial role of Gs-α signaling in the growth, differentiation, and structure of these tissues.<p class...

A 72-year-old woman was initially referred by her GP to the colorectal service of our Hospital. She had a 4-month history of weight loss, fatigue and appetite loss.The initial blood tests at the GP surgery revealed a normochromic normocytic anaemia.She had a diagnosis of SVT and she was on sotalol. She had never smoked nor she had a history of excess alcohol.In her initial blood tests: Hgb 9 g/dl, albumin 27 ...

Medial calcification is a major cause of premature cardiovascular mortality in chronic kidney disease. Vascular smooth muscle cells (VSMC) play a key role in this process and studies have suggested a protective role for vitamin D. The exact mechanism for this is unclear but local synthesis of 1,25-dihydroxyvitamin D (1,25D) may be important. Production of 1,25D from 25-hydroxvitamin D (25D) is catalyzed by 25-hydroxyvitamin D-1α-hydroxylase (1α-OHase). 1,25D is metab...

Background: Vitamin D deficiency is very common in older persons. It is not clear how serum 25-hydroxyvitamin D (25(OH)D) levels change during aging.Objective: To examine longitudinal changes in serum 25(OH)D levels in two representative cohorts of Dutch older persons during 6 and 13 years of follow-up, respectively.Methods: Data of the Longitudinal Aging Study Amsterdam (LASA) were used, an ongoing cohort study in older persons. T...

Background: The study aimed to evaluate quality-of-life (QoL) aspects and impact of vitamin D deficiency in primary hyperparathyroidism (pHPT).Method: One hundred and fifty consecutive patients (119 women) with pHPT (mean age 60±11 years; BMI 27±5 kg/m2; ionized calcium 1.44±0.08 mmol/l; PTH 130±69 ng/l) were included. Six weeks postoperatively, the pHPT patients were reexamined and randomized (double-blind) to daily substi...

Introduction: In type 1 multiple endocrine neoplasia (MEN1), primary hyperparathyroidism (PHPT) is a challenging problem due to the high post-surgery recurrence rate. Cinacalcet is a calcimimetic agent which showed to be effective in patients in whom surgery is contraindicated or refused. In this study we assessed the efficacy and the safeness of cinacalcet in MEN1 patients, in comparison with patients with sporadic PHPT (sPHPT). Moreover, the influence of Arg990Gly CASR polym...

Background: α-Klotho was first identified as an aging gene and was later shown to be a regulator of phosphate metabolism. Fibroblast growth factor 23 (FGF23) is the key regulator of phosphate metabolism. Serum levels of soluble α-Klotho in chronic kidney disease (CKD) patients have not previously been determined, especially in relation with FGF23 and creatinine levels. This study was designed to investigate whether serum soluble α-Klotho levels are modulated by ...

Introduction: Vitamin D insufficiency is common in subjects with type 2 diabetes. Observational studies suggest that vitamin D plays a role in the pathogenesis of type 2 diabetes. However, results of intervention studies have been inconsistent. We investigated the effects of improving vitamin D status on insulin sensitivity and inflammatory markers in type 2 diabetic patients with vitamin D insufficiency.Methods: A double blind, randomized, placebo contr...

Introduction: Primary hyperparathyroidism (PHPT) is emerging as a cause of secondary hypertension. Between 20 and 50% of patients with PHPT have hypertension, this being directly proportional to the calcemia. The elevation of blood pressure in PHPT is mediated by hypercalcemia that acts directly stimulating the contraction of muscle fibers of the arterial vessel wall, and increases plasma renin levels and the release of catecholamines.Objectives: (1) Det...

Primary hyperparathyroidism (PHPT) negatively affects renal function. It is known that chronic kidney disease is a predictor of cardiometabolic diseases. Cystatin C (cystC), an alternative measure of renal function, has been associated with adverse cardiovascular events and cardiometabolic risk factors. This study was aimed to evaluate serum cystC, its relationships with PTH and cardiometabolic risk in patients with PHPT.The following parameters were mea...

Objective: Pseudohypoparathyroidism type 1b (PHP-1b) is rare disorders resulting from genetic and epigenetic aberrations in the GNAS locus. PHP-1b usually defined by isolated renal resistance to PTH, is due to a maternal loss of GNAS exonA/B methylation, leading to decreased Gs’α expression in specific tissues. To clarify the usefulness of methylation specific multiplex ligation-dependent probe amplification (MS-MLPA), we evaluate the genetic and epigenetic changes o...

Parathyroid hormone (PTH) secretion maintains extracellular calcium (Ca2+o) homeostasis under the control of the calcium-sensing receptor (CaR). Supra-physiological pHo changes (±1 pH unit) significantly alter CaR activity in a heterologous expression system. Interestingly, metabolic acidosis and hyperparathyroidism are concomitant in both ageing and chronic kidney disease. Therefore, here we examined whether smaller, pathophysiological pH...

There are limited data on the natural history of normocalcemic PHPT and it is unclear how the patients should be regarded vis a vis parathyroid surgery. Among the 1500 admissions/year for 10 years referred to our outpatient endocrine clinics for a variety of diseases, we collected 481 subjects with high serum levels of PTH. In the presence of hypercalcemia, a diagnosis of primary hyperparathyroidism was performed in 127 (26%). Other 354 (74%) subjects were normocalcemic: 186 (...

Introduction: Primary hyperparathyroidism is associated with cardiovascular disease. In addition, data about cardiovascular abnormalities in patients with asymptomatic primary hyperparathyroidsm (APHPT) is’nt clear. In this study, we aimed to examine the cardiac structure–functions and hs-CRP levels in patients with APHPT.Materials and method: Thirty-one patients with APHPT and 32 sex- and age-matched control cases with similar cardiac risk fac...

Background: In patients with hyperparathyroidism, parathyroidectomy is the only curative therapy. Anesthetic management differs function of etiology (primary vs secondary or tertiary hyperparathyroidism) and surgical technique (minimally invasive or classic parathyroidectomy).Aim: To evaluate peri-operative management in parathyroidectomy for hyperparathyroidism of various etiologies, in a tertiary center.Patients and methods: Two ...

Aim: In this study, our aim was to investigate frequency of impaired glucose tolerance (IGT), undiagnosed diabetes mellitus (DM) and presence of insulin resistance by HOMA.Material and method: Fifty-five primary hyperparathyroid patients without known glucose tolerance were included in this study. The control group was with similar BMI, normocalcemic, without known glucose tolerance. Seventy-five gram oral glucose tolerans test was performed to PHP patie...

Introduction: The postoperative and idiopathic (autoimmune) hypoparathyroidism are the most frequent causes of hypocalcaemia with low parathyroid hormone level. Moderate chronic hypocalcaemia frequently is asymptomatic, thus the prevalence of hypocalcaemia with low parathyroid hormone level in the general population remains unknown. Therefore, the aim of this study is to assess the prevalence of hypocalcaemia with low parathyroid hormone level in a representative sample of Pol...

Pleiotropic effects of vit. D in the etiology of obesity, metabolic syndrome and diabetes are still debated. So far published reports considered only changes in vit D plasma level in individuals with obesity and diabetes, and did not take into account the role of polymorphisms in the vit. D receptor gene.The aim of the study was to evaluate obesity, carbohydrate and lipid metabolism and vitamin D level in two VDR polymorphisms (Fok and Bsm) in Polish agi...

Introduction: The aim of this study was to compare quality of life among premenopausal women with vitamin D deficiency, vitamin D insufficiency and vitamin D sufficiency.Methods: Premenopausal women with chronic fatigue, myalgia and nonspecific body pain were divided according to their vitamin D levels: ≤20 ng/ml (vitamin D deficient, n=30), 21–29 ng/ml (vitamin D insufficient, n=30) and ≥30 ng/ml (vitamin D sufficient, ...

Introduction: Sestamibi (SM) and ultrasound (US) are routinely used for preoperative localisation of abnormal parathyroids in patients with hyperparathyroidism. Minimally invasive parathyroidectomy (MIP) is recommended if localisation is concordant, otherwise neck exploration is the method of choice.Aim: To assess whether introduction of intraoperative parathormone (IOPTH) monitoring allows us to perform MIP successfully in patients with non concordant f...

Introduction: Secondary hyperparathyroidism (SHPT) develops more frequently in the elderly. The high prevalence of chronic kidney disease and inappropriate vitamin D status are among the predisposing factors. The aim of this study is to assess the prevalence of SHPT, chronic kidney disease (CKD) and vitamin D status in a representative group of Polish elderly population.Objective: The study was carried out as a part of the nationwide PolSenior project (m...

Introduction: It has been reported that vitamin D deficiency is common in patients with primary hyperparathyroidism (pHPT), and this could affect the clinical expression of the disease. However only few studies addressed this issue and refer to American or North European patients. In these studies, only about one third of the patients showed a vitamin D replete state.Subjects and methods: In 207 consecutive pHPT patients (M/F=45/162, age (mean ±<sma...

Vitamin D deficiency has been implicated in the pathogenesis of autoimmune diseases, such as diabetes mellitus type 1 and multiple sclerosis. Reduced vitamin D intake has been linked to increased susceptibility to the development of rheumatoid arthritis (RA) and vitamin D deficiency has been found to be associated with disease activity in RA patients. The aim was to evaluate vitamin D status in RA patients and to assess the relationship between vitamin D levels and disease act...

Introduction: Primary hyperparathyroidism (PHPT) develops more frequently in the elderly with marked predisposition for female gender. The prevalence of PHPT in Poland is unknown. Therefore, the aim of this study is to assess the prevalence of PHPT in a representative sample of Polish elderly population.Description of methods/design: The study was carried out as a part of the nationwide PolSenior project (medical, psychological and socioeconomic aspects ...

The levels of bone turnover markers are elevated e.g. in osteoporosis, neoplastic diseases with bone involvement (e.g. myeloma). Recently bone markers have been found to play an important role in other diseases, like cardiovascular diseases (CVD). Vitamin D, which plays a role in body metabolism, is also an important hormone maintaining bone homeostasis.The aim of the study was to evaluate the levels of bone turnover markers (osteoprotegerin and ICTP) in...

Introduction: Primary hyperparathyroidism (PHPT) is associated with increased risk of mortality from cardiovascular disease and this appears to decrease with time after parathyroidectomy. However, data on hyperparathyroid patients are conflicting and there is no data regarding secondary hyperparathyroid patients. Our aim in this study was to determine the association between flow-mediated dilatation (endothelium dependent, FMD), nitroglycerine-induced dilatation (endothelium i...

Introduction: One of the factors influencing a predisposition to calcium renal lithiasis is a lack of crystallization inhibitors, the most important of which is citrate. The aim of our study was to analyze the importance of urinary citrate and the urinary calcium/citrate ratio in patients with calcium renal lithiasis and severe lithogenesis in comparison with control group patients without lithiasis.Methods/Design: We conducted a cross-sectional study of...

Background: The results of studies evaluating the relationship between serum 25-hydroxyvitamin D (25OHD) with intact PTH (iPTH), calcium (Ca) and phosphorus (P) levels are controversial.Objective: To determine the diagnostic values of iPTH, Ca and P for the prediction of vitamin D deficiency.Methods: We analysed iPTH, Ca and P levels in otherwise healthy 700 subjects (619 (88.4%) female, 81 (11.6%) male, mean age 47.44±16.58 y...

Background and aims: We aimed to establish the frequency of vitamin D deficiency and analyse its association with gestational diabetes (GDM).Material and methods: In this descriptive, case control and cross sectional study, pregnant women were screened at 24–28 weeks of pregnancy using a 75 g, 2 h oral glucose tolerance test. Fourthy-six GDM diagnosed (case, group 1) and 43 healthy pregnants (control, group 2) were recruited. Plasma 25-hydroxyvitami...

Objective: Primary hyperparathyroidism (PHPT) is systemic disease affecting bone metabolism and glucose homeostasis. Patients with PHPT are insulin resistant and have atherogenic dyslipidaemia. Osteocalcin (OC) is bone biomarker associated with increased insulin secretion and insulin sensitivity and decreased visceral fat The aim of our study was to evaluate the body composition and levels of bone biomarkers (osteocalcin and betaCTx), insulin sensitivity and lipids in patients...

Backgroud: The association with daily calcium intake and sarcopenia has not been well established.Objective: The objective was to assess the associate of daily calcium intake and sarcopenia.Methods: We analysed the fourth Korea National Health and Nutrition Examination Survey (KNHANES) in old adult (over 50 years), conducted in 2009. A total of 1964 non-obese (body mass index (BMI) <25 kg/m2) old adults (871 men and ...

Introduction: Two major assay systems have been used for evaluation of parathyroid hormone (PTH) secretion. Whole PTH (wPTH) recognizes full-length 84 amino acid residues [PTH(1–84)], and Intact PTH (iPTH) recognizes NH2-truncated forms, such as PTH(7–84), in addition to PTH(1–84). Patients with chronic renal failure have increased amount of PTH(7–84) in circulations, so that the ratio of wPTH/iPTH indicates 0.7 or below usually. On the other hand, chromogr...

Parathormone (PTH) is the marker for bone remodelling in chronic renal failure. The biologically active PTH 1–84 intact molecule (PTHibio) is supposed to better correlate with the degree of remodelling than PTH-intact (PTHi) which also binds to the 1–34 fragment. Our aim was to examine the PTH levels in dialysed patients with these two methods, considering also the total 25-hydroxi-vitamin-D (t-25OHD) levels.Methods: patients (age 63±15 ye...

Introduction: Obese persons may have low vitamin D levels due to behaviors (clothing, time outdoors) that can reduce synthesis of vitamin D. In overweight and obese individuals there are limited quantitative data regarding relationships among serum 25(OH)D, time spent outdoors, sun exposure, and clothing worn.Methods: We assessed environmental and behavioral factors that contribute to cutaneous synthesis of serum 25(OH)D in 63 overweight and obese indivi...

The more sophisticated laboratory methods are used, the more likely a disease is found at its asymptomatic stage. In particular, diagnosis of primary hyperparathyroidism (PHPT) is currently based not only on the presence of clinical symptoms but on the typical upswing of the serum parathyroid hormone level. Outlooks of patients with PHPT and normal serum calcium level have not been quite clear so far. We tried to contribute to this question in a prospective study that has been...

Background: Vitamin D3 is the common supplemented form, vitamin D2 is often provided as prescribed supplement in many countries, such as the USA. In these countries, measuring 25(OH)D in patients treated with vitamin D2 using an assay that measures 25(OH)D2 poorly may confound clinical care. Recently, the ADVIA Centaur vitamin D assay has been commercialized for use in the clinical laboratory. We evaluated the assay’s ability of measuring both 25(OH)D2 and 25(OH)D3 and co...

Background: We studied a cohort of hyperparathyroid patients in order to elucidate their clinical, laboratory, radiological and histological findings; the role of diagnostic imaging and concomitant thyroid pathologies.Method: 48 patients met our inclusion criteria for hypercalcaemic primary hyperparathyroidism (pHPT). We documented patients’ demographic data, symptomatology, associated conditions and treatment and analysed the work-up, management an...

Vitamin D (VitD) was shown to affect biology of vascular wall by regulating cell proliferation. However, its effects on vascular extracellular matrix (ECM) remain largely unaddressed. We investigated effects of VitD (calcitriol) on composition of ECM deposed by cultured endothelial cells (HAEC) and smooth muscle cells (HASMC) isolated from human aorta, and compared them to effects of ascorbate (VitC). Cellular monolayers were treated with or without vitamins for 72 h, then ECM...

Background: Recent studies have suggested extensive associations between plasma levels of vitamin D and hepatobiliary diseases including viral hepatitis B or C. In hepatitis C, vitamin D deficiency may lead to a poor prognosis and a poor response to antiviral treatment. CHB has different pathophysiology. There has been no study on the association of vitamin D level and the ALT level in CHB patients, and it is not known whether vitamin D levels are associated with host response...

Introduction: Primary hyperparathyroidism (PHPT) patients who undergo parathyroidectomy can develop isolated intact parathormone (iPTH) elevation with normal calcemia. Common causes are: renal insufficiency (RI), vitamin D deficit and hypomagnesemia.Aim: To identify clinical factors associated with iPTH elevation in patients submitted to surgery treatment.Methods: The medical records of patients admitted into Santo António&#14...

Pseudohypoparathyroidism (PHP) refers to a group of heterogeneous genetic diseases, characterized by resistance to PTH and frequently other hormones activating cAMP-dependent events down-stream of different G protein-coupled receptors. PHP-Ia and Ib, the most frequent forms, are caused by mutations within the GNAS locus that encodes Gαs and several splice variants thereof. We describe a 36-year-old man with sporadic PHP-Ib with renal PTH-resistance, yet severe hyperparath...

Sufficient vitamin D supply is essential for general health. The total 25-hydoxy-vitamin-D (t-25OHD) level refers to the vitamin D supply and can be measured with various methods. Since these methods are not independent of the serum matrix, differences can be obtained among vitamin D levels measured with different methods. Our aim was to study the vitamin D in healthy blood donors, taking also into consideration the use of oral contraceptives (OC).Method...

Introduction: The extracellular calcium-sensing receptor (CaSR) is a G-protein coupled receptor (GPCR) that is expressed in the parathyroids and kidneys, where it allows regulation of parathyroid hormone (PTH) secretion and extracellular calcium concentrations. Inactivating heterozyogous CaSR mutations result in familial benign hypocalciuric hypercalcaemia. However, the role of CaSR polymorphisms in controlling serum calcium, PTH and bone mineral density (BMD) remains controve...

Vitamin D deficiency is widespread among all age and ethnic groups. Serum 25-hydroxyvitamin D [25(OH)D] is the most reliable marker of vitamin D status. Adequate levels of serum 25(OH)D are necessary to sustain the pleiotropic effects of vitamin D, either skeletal (classical) or extra-skeletal (non-classical). Concentration levels ≧50 nmol/L (20 ng/ml) are required for optimal musculoskeletal health. However, levels above 75 nmol/L (30 ng/ml) may be necessary to maximiz...

Introduction: Vitamin D is important for bone and muscle development, function, and preservation. The serum 25OHD concentration is the best available clinical indicator of vitamin D status. The optimal serum 25OHD concentration is considered to be that level associated with maximal parathyroid hormone (PTH) suppression.The aim: To determine the frequency of vitamin D deficiency and insufficiency in patients of different region of Ukraine and to evaluate ...

Introduction: Italy is considered a country with high prevalence of 25 OH vitamin D deficiency. Changes in vitamin D serum levels were linked with the onset and progression of several diseases, including osteoporosis and cardiovascular diseases. The hypopituitary patients show several comorbidities like cardiovascular diseases and osteoporosis.Purpose: To evaluate the prevalence of vitamin D deficiency in hypopituitary patients.Pat...

Aim: To minimize the duration of vitamin-D insufficiency, current treatment regimes are initiated with an oral bolus dose of cholecalciferol. We have previously developed an algorithm (# Dekristol caps/Vigantol ml =(80 nmol/l – initial [s-25-OH-d-vit])/7 nmol/l) for determining the dosage of this bolus, aimed at reaching a serum 25-OH vitamin-D of 80 nmol/l. Our main aim was to investigate the accuracy of this algorithm.Materials: A retrospective st...

For decades vitamin D by its complex action in the human organism is increasingly considered to be a hormone. Therefore, the author presents here the first complex study performed in Moldova for over 10 years examining the correlation between the vitamin D status in pregnant women, newborns, their physical development after birth, the incidence of hypocalcemic states postpartum, and the prevention of rickets within the first year of life by comparing the strategy of specific r...

The majority of circulating total 25-hydroxi-D-vitamin (t-25OHD) is bound to proteins – 90% to vitamin D binding protein (DBP) belonging to the alfa-2-globulin (a-2gl) fraction and 10% to albumin (ALB). Nowadays the t-25OHD level is the most accepted marker of vitamin D supply in physiological states. Our aim was to investigate the t-25OHD concentration in clinical conditions with low albumin levels.Methods: Seventy-three patients (39 men, 34 women;...

We have previously demonstrated that 80% of patients with PTHP will have co-existing vitamin D deficiency suggesting an increased metabolism of vitamin D. There are few data assessing the impact and safety of different vitamin D preparations on calcium, parathyroid hormone (PTH) and vitamin D in this group. Here, we report the details of replacement therapy using different vitamin D preparations.In a retrospective study of 22 (20 F:2 M and 8 Asian:14 Non...

IntroductionFamilial hypocalciuric hypercalcemia (FHH) is an autosomal dominant trait comprising hypercalcemia, hypophosphatemia and an unusually low renal clearance of calcium. The vast majority of FHH is caused by loss-of-function mutations in the gene CASR, which codes for the calcium-sensing receptor (CASR). CASR is a G-protein coupled membrane receptor expressed in the parathyroid glands and the kidneys, among other tissues. It is generally asymptom...

This cross sectional single centre study was performed at an endocrine center in northern India (latitude 29°42′N and longitude 77°02′E) to assess the prevalence of vitamin D deficiency in 234 symptomatic women presenting with musculoskeletal symptoms. The study was conducted during winter (Nov 2010–Jan 2011).Subjects were recruited from patients attending the OPD for various musculoskeletal symptoms. Inclusion criteria were sy...

Introduction: Coagulation and fibrinolysis defects were reported in primary hyperparathyroid(PHPT) patients. However, there is not enough data regarding platelet functions in this group of patients. Platelet functions of hyperparathyroid patients were measured in very few studies and they have conflicting results. Our aim was to evaluate the platelet functions in primary and secondary hyperparathyroid(SHPT) patients and to compare it with the healthy subjects.<p class="abs...

Vitamin D deficiency causes rickets in children and osteomalacia in adolescents. Rickets cases are still being reported in the Arab gulf area and worldwide. The clinical spectrum ranges from subclinical (asymptomatic) form to severe symptoms and signs including progressive bone pains, myopathy, waddling gait and bone deformities.We recorded the clinical, biochemical and radiological data 50 adolescents with severe vitamin D deficiency. Clinical symptoms ...

Introduction: Idiopathic calcification of basal ganglia (Fahr’s syndrome) is a rare pathology, mostly incidental finding or familial origin, characterized by cognitive, behavioural and motor impairment, as well as by metabolic changes, such as primary hypoparathyroidism.Report: We report a case of a 59-years old white lady who was referred to our clinic for an evaluation due to suspected Fahr’s syndrome. She had a 20 years long history of moder...

Objective: The purpose of this study was to investigate the 25-hydroxyvitamin (25(OH)D3) levels in general population.Introduction: Vitamin D is important for normal bone health. Vitamin D deficiency is a well-known cause of rickets in children and osteomalacia in adults, and it is also of importance for development of osteoporosis. Beyond this, vitamin D deficiency is suggested as a contributing factor in the development of several other diseases and co...

Introduction: Vitamin D deficiency is a common disorder and may manifest as a musculoskeletal, neurological, mental disorder or neoplastic disease.Case report: A 47 year old woman of Caucasian origin suffered from back, muscle, bone pain and severe depression for 8 years. She was ineffectively treated at the departments of Neurology, Psychiatry, Pain Clinic several times a year. Brain, bone CT, internal ultrasound, routine biochemistry analyses were norm...

Aim: In this study our aim was to evaluate clinical and laboratory findings of our primary hyperparathyroid patients and detect complications caused by hyperparathroidism.Method: Eighty-three patients (73 women, 10 men) were included in this study. Serum calcium (Ca), phosphorus (P), parathormone (PTH), 25(OH) D, 24 hour urine Ca and P levels, bone mineral density (BMD) and renal ultrasonography were evaluated.Results: The mean age...

Introduction: Cinacalcet is an oral calcimimetic indicated in treatment of primary hyperparathyroidism if patients do not accept surgery, do not carry out the surgical criteria, there is failure of previous surgery or serious comorbidity that makes surgery impossible.Methods: Descriptive study that included 34 patients with primary hyperparathyroidism treated with cinacalcet. We recorded clinical and biochemical data before and after 6 months of treateme...

Introduction: Primary Hypoparathyroidism presents most commonly in childhood to early adolescence. Disease may be familial or sporadic.Most commonly hypoparathyroidism is secondary to neck operations especially Thyroid surgeries. Primary can be congenital eg- Digeorge syndrome or inherited by AD, AR or X linked mediated.We report 2 cases of late onset seizure due to Digeorge syndrome and Autosomal Dominant Hypoparathyroidism in a elderly lady.Case Report...

Vitamin D deficiency seems to be more prevalent in patients with primary hyperparathyroidism (PHPT) than in general population. This association has many clinical and therapeutic implications.The aim of this study was to assess the vitamin D status of patients with PHPT and to describe the clinical presentation of the disease when vitamin D deficiency is associated.Methods: We studied in a retrospective manner, the case of seven pa...

The aim of this work is to present two patients with vitamin D deficiency and primary HPT.A 51-year old woman (first refer, 2009-jul) was operated for pathohistologically confirmed parathyroid (PT) adenoma seen by ultrasound (US) and scintigraphy (Sc). Patient treated for previous years for hypertension and depression. Calcium (Ca; mmol/l): 3.1; Creatinine (Cre; μmol/l): 67. The results will be shown in following order: pre-/postoperatively, 3rd mon...