Searchable abstracts of presentations at key conferences in endocrinology
Previous issue | Volume 29 | ICEECE2012 | Next issue

15th International & 14th European Congress of Endocrinology

Poster Presentations

Bone & Osteoporosis

ea0029p129 | Bone & Osteoporosis | ICEECE2012

Unilateral and bilateral adrenal incidentaloma: comparing clinical and biochemical features

Eller-Vainicher C. , Morelli V. , Salcuni A. , Palmieri S. , Zhukouskaya V. , Scillitani A. , Beck-Peccoz P. , Chiodini I.

Introduction: Subclinical hypercortisolism (SH), affecting about 30% of patients with unilateral adrenal incidentaloma (UAI), has been associated to hypertension (HT), type 2 diabetes mellitus (T2DM), dyslipidemia (DL), osteoporosis and vertebral fractures (FX). The prevalence of SH in patients with bilateral adrenal incidentaloma (BAI) seems to be even higher. Data on metabolic and bone complications in these patients are lacking.Methods/design: We enro...

ea0029p130 | Bone & Osteoporosis | ICEECE2012

Bone mineral density is associated with BsmI vitamin D receptor’s polymorphism in adult patients with epilepsy

Armeni E. , Triantafyllou N. , Kaparos G. , Alexandrou A. , Logothetis E. , Creatsa M. , Antoniou A. , Kouskouni E. , Lambrinoudaki I.

Introduction: The BsmI restriction fragment polymorphism of the vitamin D receptor (VDR) has been related with the development of bone disease in postmenopause, homozygous β thalassemia and hyperthyroidism. The present study aimed to evaluate the association between bone metabolism in patients with epilepsy and the BsmI VDR’s polymorphism.Methods/design: This cross-sectional study evaluated 73 adult patients with epilepsy, under antiepileptic d...

ea0029p131 | Bone & Osteoporosis | ICEECE2012

Vitamin D and estrogen receptors’ polymorphisms in postmenopausal women

Oros S. , Ianas O. , Vladoiu S. , Giurcaneanu M. , Neacsu E. , Voicu G. , Stoiceanu M. , Rosca R. , Neamtu C. , Badiu C. , Dumitrache C.

Osteoporosis is a polygenic disease. The intensive search for genetic markers has led to the identification of several genetic polymorphisms, associated with the decrease of bone tissue and therefore a higher risk of osteoporosis.The study aimed to evaluate estrogen receptor alpha (ESR1) and vitamin D receptor (VDR) polymorphisms in postmenopausal women with or without osteoporosis and their correlations with bone markers and adipocytokines.<p class=...

ea0029p132 | Bone &amp; Osteoporosis | ICEECE2012

Osteoporosis and vitamin D deficiency in patients with lipid storage disease

Del Prete M. , Negri A. , Sarnataro M. , Pivonello C. , Ramundo V. , Marotta V. , Russo R. , Carratu A. , Cianciaruso B. , Colao A. , Pisani A. , Faggiano A.

Introduction: Bone metabolism is impaired in several lipid storage diseases. At now no data are available in Fabry disease (FD), a genetic lipid storage disease characterized by systemic accumulation of glicolipids. The aim of this study was to evaluate bone metabolism and calcium/vitamin-D pathway in patients with FD.Methods/design: Study population included 15 FD patients (8 M and 7 F, age 28–59 years) and 15 sex-, age- and BMI-matched normal subj...

ea0029p133 | Bone &amp; Osteoporosis | ICEECE2012

De novo autoimmune hepatitis associated with PTH(1–34) and PTH(1–84) administration for severe osteoporosis in a liver transplant patient

Anagnostis P. , Efstathiadou Z. , Akriviadis E. , Hytiroglou P. , Kita M.

Introduction: Recombinant parathyroid hormone 1–34 (PTH(1–34)) and 1–84 (PTH(1–84)) stimulate new bone formation and are associated with significant decrease in the risk of vertebral and non-vertebral fractures. De novo autoimmune hepatitis (AIH) is a rare graft dysfunction occurring in patients having undergone liver transplantation (LT) for causes other than AIH.Case report: A 61-year old woman was referred to our metabolic b...

ea0029p134 | Bone &amp; Osteoporosis | ICEECE2012

Osteogenesis imperfecta: phenotypic characteristics and response to treatment in an Irish cohort

O'Sullivan E. , McKenna M.

Background: Osteogenesis imperfecta is a group of heterogenous disorders affecting connective tissue. The disorders are inherited by autosomal dominant or recessive patterns. The phenotypes vary both between and within the subgroups of which there are eight described by the modified Sillence criteria. The common features are reduced bone mineralization, predisposition to fracture and resulting bony deformities. In addition blue sclerae and joint hyperlaxity can be present....

ea0029p135 | Bone &amp; Osteoporosis | ICEECE2012

Bone mineral density in diabetic postmenopausal women with bone fracture

Gusova A. , Pavlova M. , Melnichenko G. , Kavalersky G.

Introduction: There are contradicting data about bone mineral density (BMD) in patients with type 2 diabetes mellitus (DM), although most studies describe increased BMD values in them. Due to this finding it is not clear how tightly bone fragility is bound with BMD in type 2 diabetic people.Design: We provided dual-energy X-ray absorptiometry of lumbar spine and proximal femur to 46 postmenopausal women with type 2 diabetes mellitus (DM), 14 of them had ...

ea0029p136 | Bone &amp; Osteoporosis | ICEECE2012

Evidence for vitamin D deficiency and increased fractures’ prevalence in autoimmune bullous skin diseases

Eller-Vainicher C. , Marzano A. , Trevisan V. , Cairoli E. , Zhukouskaya V. , Marchese L. , Morelli V. , Beck-Peccoz P. , Crosti C. , Chiodini I.

Background: Vitamin D deficiency plays a role in autoimmune diseases and risk of fractures. No data are available on vitamin D levels and vertebral fractures in autoimmune bullous skin diseases.Objectives: To assess vitamin D serum levels and vertebral fractures’ prevalence in patients with pemphigus vulgaris (PV) and bullous pemphigoid (BP), potentially deadly autoimmune bullous disorders.Methods: We studied 13 consecutive ac...

ea0029p137 | Bone &amp; Osteoporosis | ICEECE2012

A correlation between bone mass density and body mass index and the lipid profile?

Radoi V. , Carsote M. , Virgolici B. , Poiana C.

Bone mass density and beta cross laps have been recognized as valid tests for the diagnostic and treatment control, as well as fracture prediction for osteoporotic patients. Statin treatment has been reported to be associated with a reduced risk fracture in these patients also. However, no studies, as of our knowledge, have tried to see if adding the lipid profile to the analysis of body mass density would improve the statistical power of prediction for any of the afore mentio...

ea0029p138 | Bone &amp; Osteoporosis | ICEECE2012

Vertebral fracture risk and bone metabolism in patients with addison’s disease

Camozzi V. , Betterle C. , De Caneva E. , Lucato P. , Piccolo M. , Zaninotto M. , Silvia G. , Rizzati S. , Mantero F. , Luisetto G.

Forty seven patients suffering from Addison’s disease (AD: 12 males and 35 females, 44.5±12.7 year old) were compared with 63 normal age-, sex- and BMI-matched subjects.The duration of disease ranged from 0.6 to 44 years (10.23±9.07 years). AD had received a cumulative dose of cortisone acetate of 290.5±326.8 g, equivalent to a daily dose of 44.5±15.5 mg, and to 26.34±10.57 mg/m2 of body surface. AD had average va...

ea0029p139 | Bone &amp; Osteoporosis | ICEECE2012

Bone mineral density and muscle mass in women with multiple sclerosis

Zikan V. , Tyblova M. , Luchavova M. , Havrdova E. , Raska I. , Michalska D. , Kubena A.

Aim: The aim of this study was to compare the bone mineral density (BMD) and muscle mass between ambulatory women with multiple sclerosis (MS) and control subjects and to examine the influence of motor disability, muscle mass and/or glucocorticoids (GC) use on BMD.Methods: Body composition and BMD were measured by dual-energy X-ray absorptiometry in 250 ambulatory MS women (153 premenopausal and 97 postmenopausal women) with Expanded Disability Status Sc...

ea0029p140 | Bone &amp; Osteoporosis | ICEECE2012

Teriparatide: effects on cortical bone microstructure

Stepan J. , Dobnig H. , Fahrleitner-Pammer A. , Ma Y. , Zeng Q. , Wan X. , Marin F. , Pavo I.

Teriparatide (TPTD) reduces the vertebral and nonvertebral fracture risk. TPTD increases bone formation and improves the cancellous bone microstructure which is an important determinant of the mechanical integrity of vertebrae. The aim of our study was to evaluate first time the effect of TPTD on cortical microstructure and dynamic histomorphometric indices in patients with osteoporosis with or without prior therapy with ALN. Sixty-six postmenopausal women with osteoporosis, m...

ea0029p141 | Bone &amp; Osteoporosis | ICEECE2012

Serum soluble RANKL levels are related to breast arterial calcification and hypertension in Japanese osteoporotic postmenopausal women

Hirano F. , Wada H. , Nishimura H.

It has been suggested that the association between osteoporosis and cardio-vascular diseases is not just due to the aging process. The osteoprotegerin (OPG)/RANKL system has been identified as a possible mediator of arterial calcification suggesting common links between osteoporosis and vascular diseases. Moreover, breast arterial calcification (BAC) is reported to be associated with an increased prevalence of both cardiovascular risk factors and cardiovascular morbidity. In c...

ea0029p142 | Bone &amp; Osteoporosis | ICEECE2012

BMP-3b inhibits osteoblast differentiation via Smad2/3 pathway by counteracting Smad1/5/8 signaling

Otsuka F. , Hino J. , Matsumoto Y. , Miyoshi T. , Takano M. , Miyazato M. , Makino H. , Kangawa K.

Involvement of BMP-3b (also called GDF-10) in osteogenesis, embryogenesis and adipogenesis has been reported to date. However, the functional receptors and intracellular signaling of BMP-3b have yet to be determined. In the present study, we studied the cellular mechanism of BMP-3b in osteoblast differentiation using mouse myoblastic C2C12 cells, which show osteoblasitc differentiation in response to osteogenetic BMP ligands. BMP-3b stimulated activin/TGF-β-responsive pro...

ea0029p143 | Bone &amp; Osteoporosis | ICEECE2012

Glucocorticoid - treatment in the adrogenital syndrome due to deficit of 21-hydroxylase: long-term bone side effects

Camozzi V. , Scaroni C. , De Toni P. , Albiger N. , Zaninotto M. , Mantero F. , Luisetto G.

The purpose of this study was to compare bone mineral density (BMD) and bone metabolism in patients suffering from adrogenital syndrome due to deficit of 21-hydroxylase with those of a group of healthy subjects. A longitudinal follow-up was also carried out in a subgroup of patients.Thirty-eight patients 19-47 years old were compared with a group of healthy, age- and sex-matched controls. Sodium, potassium, calcium, phosphorus, parathyroid hormone (PTH),...

ea0029p144 | Bone &amp; Osteoporosis | ICEECE2012

Polymorphism of the vitamin D3 receptor gene and bone mineral density in girls with functional hypothalamic amenorrhea subjected to estroprogestagen treatment

Sowinska-Przepiera E. , Poblocki J. , Friebe Z. , Jarzabek-Bielecka G. , Andrysiak-Mamos E. , Syrenicz A.

Background: We analyzed in the vitamin D3 receptor gene (VDR) polymorphism can modulate therapeutic response of functional hypothalamic amenorrhea (FHA) patients to the estroprogestagen (EP) treatment.Material and methods: The study included 84 FHA girls and 50 controls. FHA patients underwent a 4-year sequential EP therapy with 17-β estradiol (2 mg from the 2nd to 25th day of the menstrual cycle) and didrogesterone (10 mg from the 16th to the 25th ...

ea0029p145 | Bone &amp; Osteoporosis | ICEECE2012

Altered bone mineral density in unilaterally orchiectomized subjects

Selice R. , De Toni L. , Strapazzon G. , Di Mambro A. , Ferlin A. , Garolla A. , Foresta C.

Introduction: Testicular cancer (TC) is the most common cancer in white males aged 20–40 years, with a worldwide incidence of 7.5/100.000. Recently, we demonstrated an association between testiculopathy and alteration of the bone status, despite conserved bone-sparing effects of androgens and estrogens. Furthermore, recent published data from our group documented a strong reduction in 25(OH)D plasma levels in bilaterally orchiectomized patients compensated by testosterone...

ea0029p146 | Bone &amp; Osteoporosis | ICEECE2012

Effects of aminobisphosphonates and thiazides in patients with osteopenia/osteoporosis, hypercalciuria and recurring renal calcium lithiasis

Sueliman-Martos Y. , Arrabal-Polo M. , Jimenez-Pacheco A. , Zuluaga-Gomez A. , Escobar-Jimenez F. , Arrbal-Martin M.

Introduction: A relationship between osteopenia/osteoporosis and calcium nephrolithiasis has been recognized in several studies. An association has also been observed between bone mineral density loss, hypercalciuria, hypocitraturia and nephrolithiasis.The aim of this study was to analyze the effects of aminobisphosphonates and thiazides on renal lithogenic activity and bone mineral density in patients with recurring renal calcium lithiasis.<p class=...

ea0029p147 | Bone &amp; Osteoporosis | ICEECE2012

Bone mineral density in patients with thalassaemia major in the UK

Tzoulis P. , Ang A. , Shah F. , Barnard M.

Introduction: Osteoporosis is a major cause of morbidity in β thalassaemia major patients. Our institution serves one of UK’s largest populations of thalassaemia patients. This study aimed to examine the prevalence of osteopenia and osteoporosis in thalassaemia major patients and identify risk factors for low bone mineral density (BMD).Methods: BMD of lumbar spine and neck of femur were measured using dual-emission X-ray absorptiometry (DEXA). ...

ea0029p148 | Bone &amp; Osteoporosis | ICEECE2012

Abstract withdrawn....

ea0029p149 | Bone &amp; Osteoporosis | ICEECE2012

Both high- and low levels of procollagen type 1 amino-terminal propeptide are associated with increased risk of hip fracture in elderly women. Norwegian Epidemiologic Osteoporosis Studies

Finnes T. , Lofthus C. , Meyer H. , Eriksen E. , Tell G. , Holvik K.

Aim: The study aimed to investigate the relation between the levels of the bone formation marker P1NP and the risk of subsequent hip fractures in elderly women.Materials and methods: Women born 1924–27 who participated in two population-based health studies in Bergen (The Hordaland Health Study (HUSK) 1997–2000) and in Oslo (The Oslo Health Study (HUBRO) 2000–2001), were followed up regarding hip fractures from date of inclusion until end ...

ea0029p150 | Bone &amp; Osteoporosis | ICEECE2012

Alendronate inhibits adipocyte differentiation in 3T3-L1 through a Vitamin D receptor mediated effect

Caprio M. , Calanchini M. , Mammi C. , Antelmi A. , Cinti F. , Fabbri A.

Background: Adipocyte and osteoblast derive from the same mesenchimal progenitor. Age-related decrease in bone mass is accompanied by an increase in marrow adipose tissue. Vitamin D3 (VD) inhibits adipogenesis in 3T3-L1 preadipocytes. Recently it has been demonstrated that alendronate (ALN) inhibits adipogenesis while promoting osteoblast differentiation of mesenchimal stem cells.Aim of the study: To evaluate the in vitro role of ALN on 3T3-L1 adi...

ea0029p151 | Bone &amp; Osteoporosis | ICEECE2012

Genetic predispositions do not explain short- and long-term effects of hormonal therapy on bone mineral density in girls with functional hypothalamic amenorrhea

Sowinska-Przepiera E. , Poblocki J. , Andrysiak-Mamos E. , Chelstowski K. , Friebe Z. , Syrenicz A.

The aim of this study was to verify if genetic factors influence the short- and long-term therapeutic response to estroprogestagen (EP) therapy implemented in girls with functional hypothalamic amenorrhea (FHA) in order to improve their bone mineral density (BMD). The study included 78 FHA girls who underwent a 4-year sequential EP therapy with 17β-estradiol and didrogesterone. Changes in the lumbar spine BMD were determined at the end of the therapy and 6 years after its...

ea0029p152 | Bone &amp; Osteoporosis | ICEECE2012

Improved assessment of bone turnover by the PTH-(1–84)/ large C-PTH fragments ratio in dialysis patients

van Helden J.

Background: The ‘intact’ parathyroid hormone (PTH) assays recognizes PTH (1–84) as well as amino terminally truncated fragments (C-PTH fragments). The present study investigated whether the use of plasma PTH-(1–84)/C-PTH fragment ratio enhances the noninvasive assessment of bone metabolism in patients on dialysis.Methods: Blood samples of 45 healthy subjects with normal ‘intact’-PTH values and 135 samples of dialysis patient...

ea0029p153 | Bone &amp; Osteoporosis | ICEECE2012

Comparaison of serum PTH concentrations obtained with a second and a third generation assay in a cohort of hemodialysis patients according to the KDIGO guidelines

Laruelle E. , Massart C.

Introduction: PTH concentrations obtained with the second generation (2G) assays may vary widely according cross-reactivities against 7–84 PTH fragments. 1–84 bio-intact PTH is only measured with a third generation (3G) assay.Objective: To evaluate whether the results found with a 3G method improve the classification of dialysis patients according to the KDIGO recommendations.Patients and methods: We studied the PTH value...

ea0029p154 | Bone &amp; Osteoporosis | ICEECE2012

Endoscopic comparison of esophageal and gastroduodenal mucosal effects of enterocoating alendronate with calcitriol combined drug and alendronate in Korean postmenopausal women

Mok J. , Yu C. , Lee C.

Introduction: The study was a single-center, open label, randomized, head-to-head clinical study to compare the mucosal findings after perform esophagogastroduodenoscopy between two groups before and after use of alendronate only and enterocoating alendronate (5 mg) with calcitriol (0.5 μg) combined drug (Maxmarvil).Methods: The 33 postmenopausal healthy volunteers, aged 50–70 years (mean age: 58±5 years) without gastrointestinal symptoms ...

ea0029p155 | Bone &amp; Osteoporosis | ICEECE2012

Functional hypoparathyroidism is a risk factor for bone fragility of postmenopausal women with vitamin D insufficiency

Yamauchi M. , Nawata K. , Kaji H. , Takaoka S. , Yamaguchi T. , Sugimoto T.

Aim: Vitamin D insufficiency is associated with an increase in PTH, which might be critical for an increase in bone fragility. However, the role of endogenous PTH in vitamin D insufficiency-induced increase in fracture risk still remains unclear. The present study was performed to examine the relationships among vitamin D insufficiency, bone fragility, PTH and sclerostin, which is produced by osteocytes and inhibits bone formation by inhibiting the Wnt pathway.<p class="ab...

ea0029p156 | Bone &amp; Osteoporosis | ICEECE2012

Platinum nanoparticle reduces ovariectomy-induced bone loss by decreasing osteoclastogenesis

Kim W. , Kim J. , Kim J. , Choi H.

Platinum nanoparticles have shown to have a remarkable antioxidant activity. Growing evidence between oxidative stress and bone loss suggests that platinum nanoparticle could protect bone loss via modulating oxidative stress. Intragastrical administration of platinum nanoparticle reduced ovariectomy (OVX)-induced bone loss with lowered level of in vivo bone resorption. Platinum nanoparticle inhibited osteoclast (OC) formation via an impaired receptor activator of nuclea...

ea0029p157 | Bone &amp; Osteoporosis | ICEECE2012

The level of Osterix expression in osteoblasts is important to prevent IL6-induced inflammatory-prone state

Baek W. , Kim Y. , Park S. , Kwon T. , Park K. , Kim J.

Osterix (Osx) is an essential transcription factor for osteoblast differentiation and bone formation. Osx null mutants died perinatally with a complete absence of bone formation and Osx conditional knockouts in osteoblasts showed the osteopenic phenotype after birth. Even in Osx heterozygous mice with normal bone morphology, the reduced cortical thickness and osteoblast differentiation were observed by QCT and in vitro cell culture, respectively. This result exhibited t...

ea0029p158 | Bone &amp; Osteoporosis | ICEECE2012

Osteopenia/osteoporosis in patients with calcium nephrolithiasis

Suleiman-Martos Y. , Arrabal-Polo M. , Jimenez-Pacheco A. , Zuluaga-Gomez A. , Escobar-Jimenez F. , Arrabal-Martin M.

Introduction: Calcium nephrolithiasis is the most frequently diagnosed type of nephrolithiasis. It is related to metabolic alterations, inhibitor deficiencies, anatomical factors, alterations in urinary pH, and bone alterations.The objective of this study is to analyze the alterations in bone mineral density and bone and calcium-phosphorus metabolism in patients with calcium nephrolithiasis.Methods/design: We designed a study with ...

ea0029p159 | Bone &amp; Osteoporosis | ICEECE2012

No effect of long-term valproate monotherapy on bone mineral density in adults with epilepsy

Triantafyllou N. , Armeni E. , Boufidou F. , Antoniou A. , Tsivgoulis G. , Lambrinoudaki I.

Introduction: Anti-epileptic drugs, usually defined according to their effect on the cytochrome P450 system, might lead to bone mineral density (BMD) decrease and fractures. The anticonvulsant valproate is a hepatic enzyme inhibitor, effective in many types of epilepsy. The present study aimed to assess the impact of long-term valproate monotherapy on BMD in a sample of consecutive ambulatory adult patients with epilepsy.Methods/design: This cross-sectio...

ea0029p160 | Bone &amp; Osteoporosis | ICEECE2012

Bone cross-sectional geometry and strength parameters at the radius by pQCT in male obese adolescents

Vandewalle S. , Roggen I. , Van Helvoirt M. , Debode P. , Taes Y. , Kaufman J. , De Schepper J.

Introduction: Male gender, adolescence and obesity are known risk factors for upper limb fractures, although the mechanism by which obesity confers the increased fracture risk is unknown. In addition, most studies investigating the influence of body fat mass on bone in adolescents have been performed in school based populations using the DXA technique, which does not take into account the material and geometric bone properties.Methods: We investigated vo...

ea0029p161 | Bone &amp; Osteoporosis | ICEECE2012

Osteonecrosis of the jaw (ONJ) with superimposed osteomyelitis related to actinomyces in a patient with multiple myeloma receiving thalidomide and intravenous zoledronic acid

Chaudhari S. , Patibandla K. , Maritato M. , Bahtiyar G. , Sacerdote A.

Patient, methods and case report: A 50-years-old AAF with a PMH of multiple myeloma (MM), hypertension, and schizophrenia presented with jaw pain for 2 months. The patient had been diagnosed with MM for 10 years and had been treated with thalidomide and IV zoledronic acid for 1 year. CT scan of facial bone was consistent with osteonecrosis of the jaw with possible, superimposed osteomyelitis. Jaw biopsy revealed necrosis with a fistulous tract and filamentous organism consiste...

ea0029p162 | Bone &amp; Osteoporosis | ICEECE2012

Effect of alcohol consumption on bone mineral density in healthy elderly Spanish males

Lavado-Garcia J. , Moran J. , Gonzalez Lopez-Arza L. , Costa-Fernandez C. , Guerrero-Bonmatty R. , Gonzalez Lopez-Arza M.

Background: There are no data concerning a relationship between alcohol and bone status of elderly Spanish men. Previous studies in other countries on the influence of alcohol intake on bone mineral density (BMD) in men are inconsistent and the effect of these variables on BMD is yet to be explored.Objective: The aim of this study was to describe the associations between total and beverage-specific alcohol intake and both BMD and bone ultrasound in elder...

ea0029p163 | Bone &amp; Osteoporosis | ICEECE2012

Effect of alendronate on bone mineral density in primary hyperparathyroidism

Szymczak J. , Bohdanowicz-Pawlak A. , Jakubowska J.

Background: Bisphosphonates are capable of suppressing parathormone (PTH)-mediated bone resorption and can be used as an adjunct treatment in acute hypercalcemia. We investigated the effects of oral alendronate on bone mineral density (BMD) and biochemical markers of calcium and bone metabolism in patients with primary hyperparathyroidism (PHPT).Methods: Twenty-six patients aged 58.5±13.9 years with confirmed PHPT were treated with alendronate (70 m...

ea0029p164 | Bone &amp; Osteoporosis | ICEECE2012

Association of monocyte chemoatractant protein-1 and adiponectin with bone mineral density and osteocalcin in postmenopausal women

Pandzic Jaksic V. , Grizelj D. , Gizdic B. , Jaksic O.

Recent findings suggested two-way interaction between bone and adipose tissue. Osteocalcin, a hormone of osteoblasts, was shown to stimulate insulin sensitivity by direct interaction with insulin. Adipose tissue has an important effect on insulin sensitivity by secretion of anti-inflammatory and proinflammatory adipocytokines like adiponectin and monocyte chemoattractant protein-1 (MCP-1). It is unknown whether they are related to bone metabolism.Aim of ...

ea0029p165 | Bone &amp; Osteoporosis | ICEECE2012

Age-dependent and sexual features of bone mineral density changes in rats with hyperthyroidism

Gopkalova I. , Povoroznyuk V.

The aim of the research was studying the influence of age and sex on the changes of bone mineral density detected on rats with experimental hyperthyroidism.Research object: Research is conducted on 180 white females and males rats of ‘Wistar’ breed. Animals were arranged in the 12 groups: six controls groups (CG) of pre-pubertal, reproductive and old males and females; six age-dependent groups of males and females rats getting L-...

ea0029p166 | Bone &amp; Osteoporosis | ICEECE2012

Sinomaxillary myopericytoma associated with oncogenic osteomalacia

Kender Z. , Polony1 G. , Godeny M. , Lerant G. , Szekely E. , Igaz P. , Racz K. , Toth M.

Oncogenic osteomalacia (tumor induced osteomalacia-TIO) is a rare disease that can lead to severe physical handicap and pains. Its pathogenesis involves the secretion of fibroblast growth factor-23 inducing urinary phosphate loss and consequent hypophosphataemia. We report a case of a TIO caused by a tumor in the nasal cavity. In 2010, a 61-years-old woman was examined because of muscle weakness and arthralgia in the extremities. Her symptomes started ~3 years before her prese...

ea0029p167 | Bone &amp; Osteoporosis | ICEECE2012

Body composition in postmenopausal women with vertebral fractures

Povoroznyuk V. , Dzerovych N.

The aim of this study is evaluating body composition in postmenopausal women depending on presence of vertebral fractures in their anamnesis.Materials and methods: We’ve examined 144 postmenopausal women aged 50–83 years (mean age – 62.9±0.7 years; mean height – 160.6±0.5 cm; mean weight – 71.9±1.2 kg). The patients were divided into two groups: group A – women without vertebral fractures (n=82), group ...

ea0029p168 | Bone &amp; Osteoporosis | ICEECE2012

Bone mineral density in relation to metabolic syndrome in postmenopausal women with diabetes type 2

Canecki-Varzic S. , Bilic-Curcic I.

Diabetes type two is associated with greater bone mineral density (BMD) due to obesity although observed rapid bone loss over time could be explained with elevated chronic inflammation. The objective of this study was to investigate the relationship between central adiposity and hyperinsulinaemia as well as inflammation markers with vertebral and femoral BMD and bone turnover markers in postmenopausal women with type two diabetes. Femoral and vertebral BMD, osteocalcin, pyrili...

ea0029p169 | Bone &amp; Osteoporosis | ICEECE2012

Assessment of bone turnover and vitamin D levels in women with postmenopausal osteoporosis and type 2 diabetes mellitus

Novakovic-Paro J. , Vukovic B. , Icin T. , Kovacev-Zavisic B. , Medic-Stojanoska M. , Mitrovic M. , Bajkin I. , Rankov O.

Background: Past research suggests that diabetes mellitus, although with still insufficiently known mechanisms, has an effect on bone turnover.Objective of this study was to determine the level of bone metabolism parameters and vitamin D in women with postmenopausal osteoporosis and type 2 diabetes mellitus.: Material and methodsThe prospective study included 30 women with postmenopausal osteoporosis and type 2 diabetes mellitus an...

ea0029p170 | Bone &amp; Osteoporosis | ICEECE2012

Osteoblast and adipocyte differentiation from human adipose tissue-derived cells

Manda D. , Oros S. , Popa O. , Baciu A. , Vladoiu S. , Ianas O. , Lascar I. , Dumitrache C.

Human adipose tissue provides abundant source of mesenchymal stem cells, which can be easily and safely harvested as compared with human bone marrow.The aim of this study was to differentiate a viable osteoblast and adipocyte cell culture from mesenchymal stem cells, an experimental model to study the interrelation between adipocytes and bone forming cells, osteoblasts.Materials and methods: Subcutaneous adipose tissue liposuction ...

ea0029p171 | Bone &amp; Osteoporosis | ICEECE2012

Denosumab increases BMD in primary hyperparathyroidism

Misiorowski W. , Zgliczynski W.

Primary hyperparathyroidism (PHPT) is often associated with reduced bone mineral density (BMD). An open-labeled, prospective trial was conducted to determine whether denosumab 60 mg subcutaneously given every 6 months, maintains or improves BMD in patients with PHPT.Six patients had symptomatic PHPT and met surgical guidelines however refused surgery, and twelve patients had mild PHPT, asymptomatic except low BMD. The primary outcome index, BMD, was meas...

ea0029p172 | Bone &amp; Osteoporosis | ICEECE2012

Relationship between bone metabolism markers, bone mineral density and insulinresistance in healthy and diabetic postmenopausal women

Perez Lopez G. , Becerra Fernandez A. , Menacho Roman M.

Introduction: Some metabolic diseases, including type 1 (T1DM) and type 2 (T2DM) diabetes mellitus have an influence on bone homeostasis. These facts are of great socio-medical impact, since currently the DM2 and osteoporosis are considered public health problems.Objectives: (1) Determine the relationship between markers of bone metabolism and insulin resistance in postmenopausal women with and without T2DM.(2) Compare the bone min...

ea0029p173 | Bone &amp; Osteoporosis | ICEECE2012

The relation between quantitative characteristics of smoking and level of female skeleton damage

Duskova M. , Pospisilova H. , Hruskovicova H. , Simunkova K. , Zofkova I. , Hill M. , Starka L.

Objective: Skeletal disability pathogenesis is multifactorial. Many studies have proved a negative relation of smoking on calcium-phosphate metabolisms, bone density and quality; however in some other papers these results have not been confirmed. The aim of the study was to monitor the influence of the length of smoking, a number of cigarettes smoked and the age of the first use of cigarettes on the whole-body bone density.Methods: Whole-body densitometr...

ea0029p174 | Bone &amp; Osteoporosis | ICEECE2012

The assessment of the behavior of the interleukins IL1β and IL6 and bone mineral density (BMD) and bone metabolism (IBM) in women of postmenopausal age

Tryniszewski W. , Gorska-Chrzastek M. , Kozlowska M. , Gadzicki M. , Raciborska I. , Zajac A. , Maziarz Z.

Women’s bone metabolism is regulated by estrogens and interleukins. During the menopausal period the estrogens’ protective activity is decreased and the production of IL1β and IL6 is increased.The aim of the studyThe assessment of the dependency between IL1β i IL6 and estradiol values and BMD and IBM in postmenopausal women.Material: Forty-eight women, age 49–61, without menstruation ...

ea0029p175 | Bone &amp; Osteoporosis | ICEECE2012

Correction of bone mineral density losing in female rats with exogenous thyrotoxicosis with calcium and alendronate preparations

Povoroznyuk V. , Oliynyk O. , Oliynyk B.

Numerous hormonal and metabolic disorders caused by thyrotoxicosis lead to serious complications, so early diagnosis and adequate treatment becomes very important in warning of functional and organic changes in several organ systems, particularly in the structure of bone tissue.The aim was study of the effectiveness of calcium and alendronate for prevention and treatment of BMD losing in experimental models of thyreotoxicosis.Mater...

ea0029p176 | Bone &amp; Osteoporosis | ICEECE2012

Reference intervals for serum N-MID osteocalcin concentration measured with the IDS-iSYS automated system

Hannemann A. , Friedrich N. , Spielhagen C. , Rettig R. , Nauck M. , Wallaschofski H.

Background: Osteocalcin (OC) is a bone-specific protein produced primarily by osteoblasts during bone formation. The OC concentration is used to assess fracture risk and monitor treatment of osteoporosis and other disorders of bone metabolism. To adequately interpret the OC concentration, it is necessary to calculate reference ranges from a healthy reference population, adapted to a specific laboratory method.Methods: We established a healthy reference p...

ea0029p177 | Bone &amp; Osteoporosis | ICEECE2012

Prevalence of morphometric vertebral fractures and bone quality measured by spinal deformity index in type 1 diabetic patients

Zhukouskaya V. , Eller-Vainicher C. , Vadzianava V. , Zhurava I. , Korolenko G. , Cairoli E. , Beck-Peccoz P. , Shepelkevich A. , Chiodini I.

Background and objectives: There are a lot of studies demonstrating low bone mineral density (BMD) and elevated fracture risk in patients with type 1 diabetes. But there are scarce data about the prevalence of morphometric vertebral fractures (MorfoFx) and spinal deformity index (SDI) that is considered as a surrogate marker of bone quality. Therefore, the objective of this study was to evaluate BMD, the prevalence of MorfoFx and bone quality by SDI in type 1 diabetics.<p ...

ea0029p178 | Bone &amp; Osteoporosis | ICEECE2012

Clinical evaluation of a new specific 1–84 PTH automated platform

Manor M. , Mayer Y.

Introduction: 2nd generation ‘Intact’ PTH assays currently available, measure 1–84 PTH and additional fragments. Recently a third generation kit developed which detects only active.1–84 PTH molecule, based on an immuno-radiometric sandwich assay.Design: Evaluation took place in an HMO central lab. 240 plasma samples collected. One hundred and sixty-one randomly out patients and 78 hospitalized nephrologic patien...

ea0029p179 | Bone &amp; Osteoporosis | ICEECE2012

Successful treatment of thyrotoxicosis is accompanied by a decrease in serum sclerostin levels

Skowronska-Jozwiak E. , Krawczyk-Rusiecka K. , Lewandowski K. , Adamczewski Z. , Bienkiewicz M. , Lewinski A.

Sclerostin, a product of a SOST gene, is a protein expressed by osteocytes that inhibits osteoblastic bone formation. Several hormones including PTH and glucocorticosteroids and have been suggested as possible regulators of sclerostin production. The influence of thyroid hormones on sclerostin synthesis has not been investigated so far. The aim of the study was to evaluate sclerostin concentrations in patients before and after treatment of thyrotoxicosis.<p class="abstext"...

ea0029p180 | Bone &amp; Osteoporosis | ICEECE2012

Investigating recurrent hypophostaemia

Agha-Jaffar R. , Reddy M. , Bassett D. , Cox J.

Oncogenic osteomalacia is a rare paraneoplastic phenomenon characterised by abnormal phosphate metabolism typically caused by discrete benign tumours. Due to the indolent presentation and slow progression, diagnosis is often delayed and localisation of the tumour can prove difficult. We present the case of a 64-years-old gentleman who was investigated by the endocrinology department for hypophosphataemia. Three years prior to this, he had started to experience exertional fatig...

ea0029p181 | Bone &amp; Osteoporosis | ICEECE2012

Ovariectomy modulates the effect of phytoestrogens on creatine kinase specific activity in skeletal organs in female rats

Somjen D. , Gayer B. , Kohen F. , Posner G. , Kaye A.

Ovariectomy of immature female rats, results in significant decreased parameters in different organs. Previously we found that estradiol-17b (E2) restored these parameters in the different organs of ovariectomized female rats (Ovx) to values obtained in intact immature female rats. E2 also stimulated creatine kinase specific activity (CK) a hormonal-responsive marker in organs containing estrogen receptors. In the present study, we compared the effects of...

ea0029p182 | Bone &amp; Osteoporosis | ICEECE2012

Bone turnover markers in medicamentous and physiological hyperprolactinemia in female rats

Radojkovic D. , Pesic M. , Antic S. , Djordjevic V. , Radenkovic S. , Kostic S. , Curkovic S. , Ciric V. , Ristic T.

Background: The aim of this study was to compare the influence of medicamentous and physiological hyperprolactinemia on bone turnover in female rats.Methods: Experimental animals (18 weeks old, Wistar female rats) were divided in the following groups: Group I: 9 rats, three week pregnant; Group II: ten female rats that were i.m. administrated Sulpirid (10 mg/kg) twice daily for three weeks; Group III: ten female rats that were i.m. administrated Sulpirid...

ea0029p183 | Bone &amp; Osteoporosis | ICEECE2012

Adiponectin and bone mineral density in obese postmenopausal women

Milin J. , Micic D. , Stamenkovic-Pejkovic D. , Jeremic D. , Kendereski A. , Zoric S. , Cvijovic G. , Sumarac-Dumanovic M.

Introduction: Adiponectin and its receptors are expressed in human osteoblasts, suggesting that adiponectin may be a hormone linking bone and fat metabolism. In contrast to adiponectin anabolic effect on bone in vitro studies, clinical and animal studies suggest that adiponectin may have negative effects on bone by stimulating the receptor activator of nuclear factor-κB ligand (RANKL) pathway and inhibiting the production of the decoy receptor for RANKL and osteopr...

ea0029p184 | Bone &amp; Osteoporosis | ICEECE2012

The body mass index and heel quantitative ultrasound analyze in 300 women

Carsote M. , Voicu G. , Radoi V. , Ene C. , Poiana C. , Coculescu M.

Introduction: The heel Quantitative Ultrasound (QUS) evaluates the bone health, with good results if the clinical risk factors are also evaluated for each patient. Among these, the body mass index (BMI) may be protective or risk factor for a fragility fracture, depending on the values.Aim: We present a study in postmenpausal women evaluated by QUS and BMI.Patients & method: This is a study in 330 patients (women in menopause wh...

ea0029p185 | Bone &amp; Osteoporosis | ICEECE2012

Cimetidine (histamine H2-receptor antagonist and antiandrogenic drug) exerts a beneficial effect in the injured tissues by periodontal disease in male rat molars

Longhini R. , de Oliveira P. , Sasso-Cerri E. , Cerri P.

Studies have demonstrated the presence of androgen receptors in osteoblasts and osteocytes, confirming that androgens are important for the maintenance of bone in men. Additionally to steroid hormones, histamine stimulates osteoclast differentiation and survival and plays a role in the inflammatory response via H2 receptors. We purposed to investigate whether cimetidine, an histamine H2 receptors antagonist and antiandrogenic drug, interferes in the periodontal tissue damages ...

ea0029p186 | Bone &amp; Osteoporosis | ICEECE2012

Age-dependent and sexual features of bone mineral density changes in rats in remote terms after hyperthyroidism abolition

Povoroznyuk V. , Gopkalova I.

The aim: To study age-dependent changes of bone mineral density of females and males rats in remote terms after hyperthyroidism abolition.Research Object: Research is conducted on 180 white females and males rats of ‘Wistar’ breed. Animals were arranged in the 18 groups: six controls groups (CG) of pre-pubertal, reproductive and old males and females; six groups of rats with the experimental model hyperthyroidism (HTG); six groups of rats 30 da...

ea0029p187 | Bone &amp; Osteoporosis | ICEECE2012

Features of bone mineral density losing in ukranian woman of different ages with thyrotoxicosis

Oliynyk O. , Povoroznyuk V.

Disorders of bone tissue as a complication of hyperthyroidism now become accepted fact. On other side decreasing of serum levels of estrogens in postmenopausal women potentially may increase effects of thyroid hormones on bone tissue.The aim of our study was investigate with DXA the features of loss of bone mass in women suffering from thyrotoxicosis depending of age and thyrotoxicosis duration.Material and methods: There were exam...

ea0029p188 | Bone &amp; Osteoporosis | ICEECE2012

Comparison of the effects of hormone replacement therapy on bone mineral density, lipid profiles, and biochemical markers of bone metabolism

Namkung J. , Chung Y. , Kwak S. , Kim J. , Kim M.

Objective: To assess the effects of hormone replacement therapy on bone mineral density (BMD), biochemical markers of bone turnover, and lipid profiles in postmenopausal women.Methods: We retrospectively reviewed the medical records of 199 postmenopausal women who had received care at the Department of Obstetrics and Gynecology of Catholic University Seoul St. Mary’s Hospital between January 1994 and December 2008. The patients were divided into the...

ea0029p189 | Bone &amp; Osteoporosis | ICEECE2012

Bone mass in diabetic patients measured by lumbar spine and hip densitometry

Icin T. , Novakovic-Paro J. , Vukovic B. , Kovacev-Zavisic B. , Medic-Stojanoska M. , Tomic-Naglic D. , Benc D. , Popovic D.

Introduction: It is known that diabetes mellitus and its complex yet insufficiently known mechanisms affect bone strength and increases the fracture risk.Objective: The aim of this study was to assess bone mass measured by lumbar spine and hip DXA, in patients suffering from diabetes mellitus according to sex and type of diabetes.Material and methods: It was a prospective study. Included 150 diabetic patients of both sexes.<p c...

ea0029p190 | Bone &amp; Osteoporosis | ICEECE2012

Efficacy, safety and adherence to treatment of teriparatide: an observational study

Franceschetti P. , Ambrosio M. , Zatelli M. , Tommasin T. , Bianchi S. , Lupo S. , Corte R La , Uberti E degli

Teriparatide is a skeletal anabolic drug that represents the first and new class of bone anabolic agents able to increase bone formation, bone mineral density and strength. Several studies demonstrated the efficacy of this drug in post-menopausal and glucocorticoid-induced osteoporosis, but few data are available on the effects of the drug in long-term therapy in humans, so far.We analyzed a population of 135 women in post-menopausal age treated with ter...

ea0029p191 | Bone &amp; Osteoporosis | ICEECE2012

Thyroxin treatment of multinodular and normofunctional goiter and bone mass.

Suarez- Lledo J.

Objective: To research changes in bone mass during treatment on MNG with thyroxin.Material and methods: For two years, patients and their clinical histories were examined when each ambulatory patient was personally visited by the author. MNG by Hashimoto’s disease and classic MNG were included. The patients with MNG in treatment were placed in the problem group, while the patients who were visited for the first time, and the patients with other endo...

ea0029p192 | Bone &amp; Osteoporosis | ICEECE2012

Vitamin D status in patients treated with intravenous ibandronate: a cohort study

Papierska L. , Misiorowski W. , Rabijewski M. , Gietka-Czernel M.

In 100 consecutive osteoporotic women referred to our clinic we assessed 25OHD3 and PTH levels. Patients suffered from postmenopausal osteoporosis and intolerance of oral bisphosphonates, were treated at least for 6 months with calcium and vitamin D. The reasons of intolerance of oral medication were gastritis (53), esophagitis (18) or peptic ulcer (29 cases). Patients were therefore chronically treated with proton pump inhibitors (PPI). They were referred to our Clinic in ord...

ea0029p193 | Bone &amp; Osteoporosis | ICEECE2012

Correlations between the bone matrix markers and bone mineral density in postmenopausal osteoporosis

Gurban C. , Balas M. , Golu I. , Amzar D. , Zosin I.

Objectives: We assessed the implications of PINP (procollagen type I N-terminal propeptide), NTX (cross-linked N-telopeptides of type I collagen), E2 (estradiol), calcium (Ca2+), phosphorus (PHOS(2−)), and their correlation with bone mineral density (BMD) in the process of bone remodeling of postmenopausal osteoporosis.Methods: The study was performed on two groups of women with postmenopausal osteoporosis (with different degr...

ea0029p194 | Bone &amp; Osteoporosis | ICEECE2012

Zoledronic acid treatment improve bone strenght parameters assessed by BMD

Galesanu C. , Loghin A. , Florescu A. , Lisnic N. , Aancute P. , Zaharia V.

Introduction: Bisphosphonates therapy is the standard of care in postmenopausal osteoporosis. In the HORIZON-RFT, annual i.v. Zoledronic acid (ZOL) 5 mg infusion significantly reduced the rate of new fractures by increased bone mineral density (BMD). We proposed to evaluate the effect of ZOL treatment in BMD change in a group of postmenopausal osteoporotic women assessed by DXA–BMD. We have proposed also to assess the adverse events of this treatment.<p class="abstext...

ea0029p195 | Bone &amp; Osteoporosis | ICEECE2012

Therapeutical management in hypogonadal osteoporosis

Bistriceanu I. , Bistriceanu M. , Popescu M. , Preda S. , Bondari S. , Bondari D. , Covei A. , Preda M.

Hypogonadal osteoporosis may occur early, asymptomatic and diagnosis is long etiology is often laborious. Early diagnosis of gonadal failure prevention measures require changes already in the prepubertal bone, puberty or postpuberal to ensure adequate peak bone mass sex and age.Casuistry is represented by 57 patients, of which the: late puberty (26 cases) and premature ovarian failure (31 cases). To elucidate the etiologic diagnosis was clinical and labo...