Searchable abstracts of presentations at key conferences in endocrinology
Previous issue | Volume 29 | ICEECE2012 | Next issue

15th International & 14th European Congress of Endocrinology

Poster Presentations

Adrenal medulla

ea0029p114 | Adrenal medulla | ICEECE2012

Next generation sequencing is a cost effective and time saving method in clinical genetic screening of patients with pheochromocytomas

Crona J. , Delgado Verdugo A. , Granberg D. , Welin S. , Stalberg P. , Hellman P. , Bjorklund P.

Background: Pheochromocytomas are rare tumours arising from adrenal medulla. Recent findings show that about 30–40% of pheochromocytomas are caused by germline mutations in one of the ten hereto known susceptibility genes: SDHA, SDHB, SDHC, SDHD, SDHAF2, RET, VHL, NF1, TMEM127 and MAX. This list of genes is constantly growing. These ten genes together consist of 128 exons and a genetic screening test is both extensive time-consuming and expensive. We introduce utilizing N...

ea0029p115 | Adrenal medulla | ICEECE2012

Pheochromocytomas: a single centre experience

Belo S. , Magalhaes A. , Nogueira C. , Carvalho D.

Introduction: Catecholamine-secreting tumors (pheochromocytomas and paragangliomas) are rare intra and extra-adrenal neoplasms, probably occurring in less than 0.2% of patients with hypertension. Serious morbidity and mortality rates are associated with these tumors which are related to the effects of catecholamines on various organs, especially those of the cardiovascular system.Methods: We reviewed the cases of pheochromocytomas and paragangliomas that...

ea0029p116 | Adrenal medulla | ICEECE2012

Removal of the dominantly secreting adrenal lateralized by bilateral adrenal venous sampling (BAVS) with glucagon stimulation significantly alleviated hypertension in patients with bilateral adrenal pheochromocytoma

Malong C. , Ngo M. , Salvador P. , Pacak K. , Mercado-Asis L.

Background: The current recommendation on the use of venous sampling is reserved for difficult cases of small pheochromocytoma. Bilateral adrenal venous sampling (BAVS) with glucagon stimulation has been reported to be safe and useful in the early diagnosis of the disease. For bilateral lesions, localization can be challenging but highly important since the removal of the dominant side can markedly improve fatal cardiovascular outcomes as a consequence of chronic hypertension....

ea0029p117 | Adrenal medulla | ICEECE2012

Neuroendocrine markers in biochemical vs pathology diagnosis of pheochromocytoma

Badiu C. , Muraru S. , Jercalau S. , Dobrescu R. , Stefanescu A.

Pheochromocytomas, tumors derived from adrenal medulla, are characterized by a polymorphic clinical picture dominated by paroxysmal hypertension. Between the clinical, laboratory and pathology data, discordances are frequently seen.Patients and Methods: Thirty five cases of pheochromocytoma and paraganglioma (10 men) with adrenal tumors and hypertension were confirmed with pheochromocytoma. They were aged 53.68±12.75 years (36–75), while the tu...

ea0029p118 | Adrenal medulla | ICEECE2012

Geranylgeraniols are essential for adrenal catecholamine secretion

Tachikawa E. , Kutsukake M. , Tamura K. , Yosie M. , Hossain M. , Taira H.

Introduction: Dolichols are isoprenoids, which are synthesized from acetyl-CoA via mevalonic acid, and they are known to be abundant in endocrine system. Adrenal medulla, which is not only an endocrine organ but also an organ derived from neural crest, secrets catecholamines via sodium and subsequent calcium influxes into the cells through nicotinic ACh receptor-operated cation channels and voltage-sensitive calcium channels, respectively, when the medulla is stimulated by ace...

ea0029p119 | Adrenal medulla | ICEECE2012

Neither classical symptoms of phaeochromocytoma nor elevated urinary catecholamines are always seen in patients with histologically verified phaeochromocytoma

Lumley S. , Reddy R. , Karavitaki N. , H Wass J.

Background: The symptom triad of ’headaches, palpitations and sweating’ along with elevated urinary catecholamine levels are commonly used to diagnose phaeochromocytoma. We wanted to assess how often patients with histologically verified phaeochromocytoma did not have this triad or had normal urinary catecholamine excretion on one occasion or more.Methods: Retrospective analysis of clinical presentation and urinary catecholamine levels in 75 pa...

ea0029p120 | Adrenal medulla | ICEECE2012

The unique case of adrenal malignant non-functioning oncocytic pheochromocytoma

Przybylik-Mazurek E. , Pach D. , Hubalewska-Dydejczyk A. , Kuzniarz-Rymarz S. , Tracz-Bujnowicz M. , Urbanik A. , Bialas M.

Introduction: Pheochromocytoma is a tumour of chromaffin cells of the sympathetic nervous system and its clinical symptoms are associated with excessive production and release of catecholamines.Case report: We report a rare case of non-functioning malignant adrenal oncocytic pheochromocytoma incidentally found during yearly repeated ultrasound abdomen examination in a 78-year-old man with history of cardiovascular diseases: aortal abdominal aneurysm, isc...

ea0029p121 | Adrenal medulla | ICEECE2012

A rare case of adrenocorticotropic hormone-producing Pheochromocytoma

Galan S. , Kann P.

Introduction: Cushing’s syndrome caused by adrenocorticotropic hormone-producing pheochromocytoma has been rarely reported. In such cases, the high production of ectopic adrenocorticotropic hormone produced by pheochromocytoma results in bilateral adrenocortical hyperplasia and thus in consecutive Cushing’s syndrome. We report a case of a 43-year-old patient with a 6 cm right-sided adrenal tumor producing both elevated levels of catecholamines and adrenocorticotropic...

ea0029p122 | Adrenal medulla | ICEECE2012

A Novel SDHC mutation associated with Head-Neck Paraganglioma

Rasmussen P. , Friis-Hansen L. , Gerdes A. , Langer S. , Feldt-Rasmussen U.

Germline mutations in the succinate-dehydrogenase subunits A, B, C, and D (SDHA/B/C/D) predispose to development of the phaeochromocytoma-paraganglioma (FPGL) syndromes. SDHC and SDHD are anchoring proteins located in the inner mitochondrial membrane. The SDH complex has two major roles in energy production it is part of the tricarboxic acid cycle catalysing the oxidative dehydrogenation of succinate coupled to the reduction of ubiquinone. It is also the complex II component o...

ea0029p123 | Adrenal medulla | ICEECE2012

Features at presentation of adrenal pheochromocytomas in castilla la mancha (spain). Is the clinical spectrum changing ?

Maqueda E. , Vicente A. , Aguirre M. , Louhibi L. , Gomez I. , Alramadan M. , Roa C. , Alvarez de Frutos V.

Background: Typical presentation of adrenal pheochromocytomas (PHEOs) is a combination of variable hypertension with paroxysmal symptoms. However, recent improvements in diagnostic imaging techniques and increasing availability of genetic testing have facilitated presymptomatic diagnosis of PHEOs.Objetive: To analyse the clinical features at presentation of PHEOs in a multicentric study population.Design and patients: Seven Spanish...

ea0029p124 | Adrenal medulla | ICEECE2012

Incidentally discovered pheochromocytoma (PH)

Kesri N. , Boudiba A. , Chentli F.

The main concern of endocrinologist exploring an adrenal incidentaloma (AI) is the identification of malignant and/or secretant AI leading to rapid cure by removal of the tumor. PH remains one of the most difficult lesions to diagnose. In this study we analyze PH clinic, morphologic and secretory profile. Among a series of 91 AI recruited between 1987 and 2007 having benefited from an adrenal exploration, 56 have been removed and 18/56 were diagnosed as tumors of medullar orig...

ea0029p125 | Adrenal medulla | ICEECE2012

Pheochromocytoma incidentally discovered after thyroid surgery manifesting dramatic hypertensive crisis induced by metoclopramide

Corsello S. , Ricciato M. , Paragliola R. , Bello G. , Bocci M. , De Crea C. , Raffaelli M. , Lombardi C. , Antonelli M. , Pontecorvi A. , Bellantone R.

Introduction: Metoclopramide is known to exert stimulatory effects on catecholamine secretion, having been used in the past as provocative test in the diagnosis of pheochromocytoma. We describe a patient with an incidentally discovered pheochromocytoma after metoclopramide administration.Case report: A 64 years-old woman underwent total thyroidectomy for multinodular goiter with ‘follicular proliferation Thy 3’ at FNAB of the target nodule. The...

ea0029p126 | Adrenal medulla | ICEECE2012

A case of adrenoleukodystrophy presenting as progressive cerebellar dysfunction

Qari F. , Nasser T.

Previously asymptomatic 29-year-old Saudi male patient, presented to with a history of dizziness, abdominal pain and diarrhea for three days.His morning 800 h serum cortisol was 6.4 μg/dl (normal: 5–25 μg/dl); plasma ACTH was 7579 pg/ml (normal: <46.00). The diagnosis of acute adrenal crisis was made which confirmed later by a defective rise in the cortisol level with ACTH stimulation test.The patient was admitte...

ea0029p127 | Adrenal medulla | ICEECE2012

Clinical peculiarities of pheochromocytoma in a MEN2A family

Sanchez Sobrino P. , Paramo Fernandez C. , Gil Gil P. , De la Fuente Aguado J. , Palmeiro Carballeira R. , Garcia-Mayor R.

Introduction: Pheochromocytoma occurs in 50% of patients with multiple endocrine neoplasia syndrome type 2A (MEN2A). It is characterized by bilateral location, production of large amounts of adrenalin and a benign course, extraadrenal location being rare. Diagnosis is achieved by measuring catecholamines and metanephrines in serum or urine and/or through imaging techniques, including CT, MRI and 123I-MIBG scintigraphy.Objective: To describe clinical feat...

ea0029p128 | Adrenal medulla | ICEECE2012

Pheochromocytoma in neurofibromatosis type 1

Moreno C. , Bastos M. , Ruas L. , Vieira A. , Alves M. , Gouveia S. , Saraiva J. , Carvalheiro M.

IntroductionNeurofibromatosis type 1 (NF-1) is a relatively frequent syndrome, with an estimated incidence of 1/3000 per year. Patients with NF-1 are at an approximately fourfold higher risk of developing tumors than the general population, most frequently gastrointestinal stromal tumors, central nervous system tumors and endocrine tumors. Pheochromocytoma may occur in about 1% of these patients.Case report: We report a 56-year-old...