Searchable abstracts of presentations at key conferences in endocrinology

ea0035p359 | Diabetes (epidemiology, pathophysiology) | ECE2014

The rs1746661 polymorphism in the FNDC5 (Irisin) gene is associated with increased levels of total cholesterol in white patients with type 2 diabetes mellitus

Boucas Ana Paula , Brondani Leticia , Assman Tais , Boelter Gabriela , Canani Luis Henrique , Crispim Daisy

Introduction: Type 2 diabetes mellitus (T2DM) is a highly prevalent chronic metabolic disease with strong co-morbidity with obesity and cardiovascular diseases. FNDC5 gene encodes a type I membrane protein that is processed proteolytically to form a newly identified hormone secreted into the blood, termed irisin. After induction by exercise, irisin activates profound changes in the subcutaneous adipose tissue, stimulating browning and UCP1 gene expression. Th...

ea0035p365 | Diabetes (epidemiology, pathophysiology) | ECE2014

UCP1, UCP2 and MnSOD expression in pancreas from brain-death subjects: A case-control study

Brondani Leticia , Boelter Gabriela , Carlessi Rodrigo , Rheinheimer Jakeline , Bauer Andrea Carla , Canani Luis Henrique , Crispim Daisy

Introduction: Long-term insulin independence after pancreatic islet transplantation depends on the engraftment of a large number of viable islets. However, the yield and quality of islets isolated from brain-death (BD) donors are negatively affected by upregulation of proinflammatory cytokines and by hypoxia and oxidative stress that occurs during the BD status. Uncoupling proteins (UCPs) are mitochondrial transporters present in the inner mitochondrial membrane and are associ...