Searchable abstracts of presentations at key conferences in endocrinology

ea0026p661 | Diabetes therapy | ECE2011

Effect of amino acid residues on N-terminal extension of GLP-1/IgG-Fc fusion protein

Lee C , Boyineni J , Chung H-S , Jang S-H

Glucagon-like peptide-1 (GLP-1) is an incretin hormone playing an important role in glucose-dependent insulin secretion and β-cell growth. However, GLP-1 is rapidly degraded by dipeptidyl peptidase IV (DPP-IV) in vivo. Many attempts have been made to develop long-acting GLP-1 analogs with chemical modification, amino acid substitution, and fusion protein technology. We previously showed that the N-terminal Ala- or Gly-extended GLP-1 and human immunoglobulin ...