ea0090oc12.1 | Oral Communications 12: Environmental Endocrinology | ECE2023
Tamez Angel
, Bravo Naila
, Garcia Emily
, Dean Frank
, Evanseck Jeffrey
, Kotsikorou Evangelia
The androgen receptor (AR) function is inhibited by endocrine disrupting chemicals (EDCs) such as DDT and DDE leading to problems in embryonic development and negative health outcomes for adults. EDCs may bind in the steroid binding pocket and disrupt AR function by leading to altered receptor conformations. However, this may not be the only way EDCs interfere with the receptor. Estébanez-Perpiñá et al identified binding function 3 (BF3) as a surface bi...