Searchable abstracts of presentations at key conferences in endocrinology
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25th European Congress of Endocrinology

Istanbul, Turkey
13 May 2023 - 16 May 2023

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ECE 2023 will be held in Istanbul, Turkey from 13-16 May 2023. Istanbul is known for its rich culture, historical sites and dynamic nightlife, and we are excited to come together in this city, and look forward to meeting old friends, making new ones, and sharing science, collaborations and ideas.

Oral Communications

Oral Communications 12: Environmental Endocrinology

ea0090oc12.1 | Oral Communications 12: Environmental Endocrinology | ECE2023

Androgen Receptor Binding by DDE at the BF3 Site Favors Release of Bound Dihydrotestosterone

Tamez Angel , Bravo Naila , Garcia Emily , Dean Frank , Evanseck Jeffrey , Kotsikorou Evangelia

The androgen receptor (AR) function is inhibited by endocrine disrupting chemicals (EDCs) such as DDT and DDE leading to problems in embryonic development and negative health outcomes for adults. EDCs may bind in the steroid binding pocket and disrupt AR function by leading to altered receptor conformations. However, this may not be the only way EDCs interfere with the receptor. Estébanez-Perpiñá et al identified binding function 3 (BF3) as a surface bi...

ea0090oc12.2 | Oral Communications 12: Environmental Endocrinology | ECE2023

Effect of circadian disruption on the hypothalamic control of reproduction in female mice

Marine Simonneaux , Mathilda Kretz , Thibault Bahougne , Valerie Simonneaux , Jeandidier Nathalie

In female mammals, the timing of the preovulatory LH surge depends on the combination of the positive estrogen feedback and a circadian signal which synchronizes the LH surge with the transition between the resting and active period at the end of the follicular phase, when arousal is maximal. Previous results have demonstrated that a functional biological clock, located in the suprachiasmatic nucleus (SCN), is required for optimal female fertility. In this context, we have inv...

ea0090oc12.3 | Oral Communications 12: Environmental Endocrinology | ECE2023

Effects of perinatal tributyltin exposure in Wistar rats on body parameters, insulin, leptin, milk composition and ultrastructure of the pancreatic islets in dams and offspring

Aparecida Miranda Rosiane , Vieira de Andrade Cherley Borba , Gaspar de Moura Egberto , Lisboa Patricia Cristina

Tributyltin (TBT) is a biocide organotin compound widely used as an antifouling in boat paints. This substance is a factor of contamination to water and food, especially marine fish. As an endocrine disruptor, TBT can interact with hormonal pathways and can induce gonadal dysfunction and glycemic dyshomeostasis; however, the effects caused by maternal exposure to TBT are scarce. Here, we investigate maternal exposure to low dose of TBT, considered safe, during pregnancy and la...

ea0090oc12.4 | Oral Communications 12: Environmental Endocrinology | ECE2023

Micronutrient deficiency screening in obese patients

Olfa Berriche , Khalaf Rahma , Amor Nadia Ben , Othman Rym Ben , Gamoudi Amel , Kacem Awatef , Henda Jamoussi

Background and Aim: A direct link between obesity and micronutrient deficiencies has been established. These nutritional dificencies are mainly caused by poor-quality diets but also due to increased demands and have been associated with a wide range of physiological and functional impairments. The aim of this study was to assess the nutritional status of obese patients and to investigate the possible association between funnctional disorders and micronutrient intake.<p cla...

ea0090oc12.5 | Oral Communications 12: Environmental Endocrinology | ECE2023

Pregnant women in the Faroe Islands are iodine depleted

Johannesen Herborg Liggjasardottir , Andersen Stig , Sofia Veyhe Anna

Introduction: Iodine deficiency is a significant global health issue of various severity depending on the age of the deficiency. The foetal period is the most critical stage in life, negatively impacting the brain and neurodevelopment. Hence, the developing foetus is a crucial issue, and the present study focussed on iodine nutrition among pregnant women from the Faroe Islands. The need for iodine increases in pregnancy, and the recommended target for median urinary iodine con...

ea0090oc12.6 | Oral Communications 12: Environmental Endocrinology | ECE2023

Effects of perinatal exposure to endocrine-disrupting chemical Tetrabromobisphenol A on neurodevelopment in mice

Kim YongIn , Kim KangMin , Jeung Eui-Bae

Tetrabromobisphenol A (TBBPA) is a brominated flame retardant and is widely used in electronic goods, plastics and furniture. TBBPA is frequently detected in water, soil, organisms and even in human breast milk. It is accessible to both the developing fetus and the nursing pups following maternal exposure. Though some regulatory agencies have asserted that consumer exposures to TBBPA are unlikely to have adverse implications for human health, the safety of TBBPA has been quest...

ea0090oc12.7 | Oral Communications 12: Environmental Endocrinology | ECE2023

Polychlorinated biphenyls (PCBs) modulate AHR pathways leading to the altered expression of genes involved in extra-cellular matrix (ECM) remodeling and epigenetic regulation in thyrocytes

Minuti Aurelio , Aliquo Federica , Giani Fiorenza , Lagana Martina , Ragonese Marta , Avenoso Angela , Cannavo Salvatore , Scuruchi Michele , D'Ascola Angela , Ruggeri Rosaria

Background: PCBs are chemical pollutants able to promote inflammation and carcinogenesis. They can accumulate in human tissues through the food chain causing a variety of adverse health effects. The NF-E2 p45-related factor 2 (NRF2) and the aryl hydrocarbon receptor (AHR) are ligand activated transcription factors controlling pathways modulating xenobiotic metabolism. Increasing evidence indicate the involvement of AhR in regulating extracellular matrix (ECM) homeostasis. ECM ...

ea0090oc12.8 | Oral Communications 12: Environmental Endocrinology | ECE2023

Bisphenols in adrenocortical cell culture: Further evidence for the relevance of endocrine disruptive chemicals for adrenal gland functionality

Potzl Benedikt , Kuerzinger Lydia , Kendl Sabine , Fassnacht Martin , Kurlbaum Max , Dischinger Ulrich

Background: Bisphenol A (BPA) is known to act as an endocrine disruptor in different organs. However, its impact on adrenal gland functionality is largely unknown. This also applies to its substitute substances bisphenol F (BPF) and S (BPS). Therefore, experiments addressing this subject are urgently needed.Methods: The human adrenocortical cell lines NCI-H295R and MUC-1 were treated with increasing concentrations (1 nM – 1 mM) o...