Endocrine Abstracts

Introduction: New drug approaches are urgently required to improve radioiodide (RAI) uptake for efficient ablation of thyroid cancer cells in RAI-refractory disease. Employing high-throughput screening of FDA-approved compounds we recently identified drugs capable of robust induction of sodium iodide symporter (NIS) activity to promote RAI uptake1. In particular, a leading drug candidate – the well-established anti-alcoholism drug disulfiram (DSF) – had no...

Introduction: Polycystic ovary syndrome affects 10% of women and comes with a 2-3fold increased risk of type 2 diabetes, hypertension, and fatty liver disease. Androgen excess, a cardinal feature of PCOS, has been implicated as a major contributor to metabolic risk. Adrenal-derived 11-oxygenated androgens represent an important component of PCOS-related androgen excess and are preferentially activated in adipose tissue. We aimed to identify PCOS sub-types with distinct androge...

Background: Non-alcoholic fatty liver disease (NAFLD) is a common comorbidity in obese individuals. GLP-1 agonists, such as semaglutide, and SGLT-2 inhibitors, such as empagliflozin, are well known to be beneficial in NAFLD, while other incretins, like peptide tyrosine tyrosine 3-36 (PYY3-36), might be also useful for the treatment of NAFLD. We directly compared the effects of semaglutide alone and in combination with peptide tyrosine tyrosine 3-36 (PYY3-36), empagliflozin and...

Background: Medical treatment with cortisol-lowering drugs is commonly used following pituitary surgical failure or recurrence of hypercortisolism in patients with Cushing’s disease (CD). Studies using late-night salivary cortisol (LNSF) measurement have shown persistent disruption of the circadian secretion of cortisol despite normalization of UFC in a subset of medically treated CD patients. Study aim Our objective was to assess the long-term cortisol exposure in CD pat...

Background: Hyperprolactinemia, caused by chronic use of antipsychotics, is associated with impaired bone density and increased risk of fractures. We examined if calcium and vitamin D supplementation have influence on Prlr gene expression in the duodenum, vertebrae and kidneys in female rats with sulpiride-induced hyperprolactinemia.Methods: Wistar female rats 21 weeks old were divided into: Group S: 10 rats that were intramuscular administrated Sulpirid...

Background: Transsphenoidal surgery (TSS) is the primary treatment of choice in acromegaly. Previous research succeeded to some extent in predicting remission after TSS. However, it was based mainly on clinical and radiological data, lacking histopathological evaluation.Objective: To produce a clinicopathological prediction model for remission after TSS for acromegaly, enabling clinicians to better inform patients on expected treatment outcome.<p cla...