ea0059p106 | Diabetes & cardiovascular | SFEBES2018
Ast Julia
, Podewin Tom
, Arvaniti Anastasia
, Fine Nick HF
, Stamataki Zania
, Broichhagen Johannes
, Johnsson Kai
, Hodson David J
The glucagon-like peptide-1 receptor (GLP-1R) is a G protein-coupled receptor (GPCR) expressed in various tissues such as brain and pancreas where it contributes to the regulation of energy expenditure and metabolism. Due to its involvement in glucose-dependent release of insulin from pancreatic beta cells, the GLP-1R has become a blockbuster target for the treatment of type 2 diabetes. Despite this, debate still exists about the exact distribution of the GLP-1R throughout the...