Endocrine Abstracts

Objective: Osteopontin (OPN) is a proinflamatory cytokine involved in the pathogenesis of insulin resistance and atherosclerosis. Adiponectin (ADP), an adipocyte-derived vasoactive and insulin-sensitizing peptide, exerts anti-inflamatory and anti-atherosclerotic effects on endotheliocytes. We aimed at determining in type 2 diabetes patients the relationship between serum OPN, serum ADP and either lower-limb atherosclerotic peripheral arterial disease (PAD) and/or mediacalcinos...

Objectives: The bone-related peptide osteoprotegerin (OPG) was recently found in high concentration inside vascular tissues in diabetic patients. OPG is produced by vascular smooth muscle cells and endotheliocytes, and inhibits progression of advanced plaque by delaying size progression as well as plaque calcification. We aimed at determining in type 2 diabetes patients the relationship between serum OPG and circulating level of angiotensin II (AngII), but also the relationshi...

Background: Insulinomas are the most common functional neuroendocrine tumours of the pancreas. Hypoglycaemic manifestations are highly variable and largely independent on tumour size and severity of insulin hypersecretion.Objectives: In this study we investigated the clinical, biological and tumoural characteristics of a large series of patients with insulinoma and we evaluated the sensitivity of peripheral tissues to insulin before and after surgery.</p...