Searchable abstracts of presentations at key conferences in endocrinology

ea0014p626 | (1) | ECE2007

Androgenicity, androgen receptor polymorphism and pharmacogenetics

Canale Domenico , Moschini Cecilia , Caglieresi Carolina , Moscatelli Agnese , Gavioli Silvia , Macchia Enrico , Martino Enio

Exon 1 of the androgen receptor (AR) gene contains a variable number of CAG triplets, (CAGr)n which encode a polyglutamine stretch of variable length in the N-terminal domain of the receptor. Experimental evidence has accumulated in demonstrating that the length of this stretch influences the transcriptional activity induced by the AR and therefore modulates target organs responsiveness to androgens.The (CAGr)n is inversely associated with the transcript...