ea0070aep940 | Thyroid | ECE2020
Ruggeri Rosaria
, Teresa Vicchio Maria
, Campennì Alfredo
, Campo Salvatore
, Trimarchi Francesco
, Cannavo’ Salvatore
, D’Ascola Angela
Background: The expression of thyroid-specific genes [thyroglobulin (Tg) and sodium iodide symporter (NIS)] is modulated by several cytokines (IL-1, IFNγ, TGF-ß) and it is down-regulated in Hashimoto’s thyroiditis (HT). Also, lymphocytic infiltration and inflammation in HT results in intra-thyroidal accumulation of hyaluronan (HA). During inflammation, HA can be degraded into small fragments, able to up-regulate pro-inflammatory genes by stimulating the toll-li...