Searchable abstracts of presentations at key conferences in endocrinology

ea0090p142 | Pituitary and Neuroendocrinology | ECE2023

Characterization of a large cohort of patients with “micromegaly”: long-term follow-up and preliminary data on treatment response

Carosi Giulia , Mangone Alessandra , Sala Elisa , Del Sindaco Giulia , Mungari Roberta , Cremaschi Arianna , Ferrante Emanuele , Arosio Maura , Mantovani Giovanna

Background: In a previous study, we retrospectively analysed a group of patients with high insulin growth factor 1 (IGF1) but normal growth hormone (GH) suppression, identifying among them a subgroup of “micromegalic” patients presenting with clinical features of acromegaly and high rate of comorbidities. We therefore expanded our cohort of patients, extended the follow-up time and collected preliminary data on treatment response aiming to better characterize this co...

ea0063p725 | Pituitary and Neuroendocrinology 2 | ECE2019

Remission rate of acromegaly after somatostatin analogs withdrawal: an update

Carosi Giulia , Sala Elisa , Sindaco Giulia Del , Verrua Elisa , Serban Andreea Liliana , Ferrante Emanuele , Arosio Maura , Mantovani Giovanna

Objective: Several studies reported that a long-time therapy with somatostatin analogs (SSTa) in acromegaly could induce persistent remission event after drug withdrawal. The aim of this study was to evaluate GH/IGF-I secretion after SSTa discontinuation in a series of acromegalic patients.Materials and methods: Data of 21 patients regularly referred to our Centre and previously included in a multicentre study, have been updated at the last available fol...

ea0063p1006 | Environment, Society and Governance | ECE2019

Telemedicine in the management of acromegalic patients

Sindaco Giulia Del , Sala Elisa , Carosi Giulia , Verrua Elisa , Serban Andreea Liliana , Ferrante Emanuele , Arosio Maura , Mantovani Giovanna

Background: In acromegalic patients, quality of life reduction and neuropsychological impairment are common, in addition to well-known complications related to the pituitary adenoma and to the GH/IGF-I excess. Acromegalic patients need a lot of outpatient visits and a multidisciplinary approach during the management of the disease and its comorbidities. Aim of the project is to analyze the role of an electronic health device (eHD) with remote monitoring in management of acrome...

ea0037ep806 | Pituitary: clinical | ECE2015

Psychological and neurocognitive evaluation in patients with pituitary adenoma

Sala Elisa , Zarino Barbara , Malchiodi Elena , Verrua Elisa , Carosi Giulia , Locatelli Marco , Rampini Paolo , Carrabba Giorgio , Spada Anna , Mantovani Giovanna

Reduced health-related quality of life (HRQoL) and impairment in neurocognitive functions are a possible complaint in patients with pituitary adenoma. Psychiatric comorbidities in Cushing’s disease are well known. However recent studies showed HRQoL reduction and psychiatric symptoms in patients with pituitary disease with or without hormonal excess. Aim of this study is to analyse HRQoL, psychiatric symptoms and neurocognitive functions in patients with pituitary adenoma...

ea0035p845 | Pituitary Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2014

NFPA and hypopituitarism: a retrospective analysis of 260 patients and focus on the prevalence of isolated hypoadrenalism

Carosi Giulia , Malchiodi Elena , Ferrante Emanuele , Sala Elisa , Verrua Elisa , Beck-Peccoz Paolo , Spada Anna , Mantovani Giovanna

Introduction: Non-functioning pituitary adenomas (NFPA) accounts for about 40% of all pituitary tumors. One or more anteropituitary deficiencies are present at diagnosis in 60–80% of NFPA. Hypopituitarism classically appears with the following order: GH→FSH/LH→TSH→ACTH. Aim of the study was to evaluate the incidence and the order of appearance of pituitary deficiencies in patients with NFPA.Materials and methods: We retrospectively...

ea0070aep694 | Pituitary and Neuroendocrinology | ECE2020

Micromegaly or acromegaly? A retrospective longitudinal study on clinical aspects and comorbidities in a large cohort of patients referred to a single tertiary center

Carosi Giulia , Sala Elisa , Mangone Alessandra , Del Sindaco Giulia , Mungari Roberta , Cremaschi Arianna , Ferrante Emanuele , Arosio Maura , Mantovani Giovanna

Introduction: The diagnosis of acromegaly is confirmed in the presence of high IGF-1 levels and inadequate suppression of growth hormone (GH) after glucose load. According to guidelines, a GH nadir (GHn)>0.4 ng/ml is considered diagnostic with ultrasensitive assays. However, some acromegalic patients with lower GHn, also called ‘micromegalic’, are reported, but a systematic collection of their clinical features is unavailable.Aim of the s...

ea0056oc11.5 | Clinical practice in endocrine tumours: combining conventional and molecular features | ECE2018

Natural history of Rathke’s Cleft Cysts: a multicenter experience

Sala Elisa , Moore Justin M , Amorin Alvaro , Carosi Giulia , Harsh Griffith R , Arosio Maura , Mantovani Giovanna , Katznelson Laurence

Objective: Rathke’s Cleft Cyst (RCC) is a common incidental type of sellar lesion, and, depending on size, may cause local mass effects with visual impairment, hypopituitarism, and headaches. In this study, we sought to define the natural history of RCC.Methods: We performed a retrospective study of patients diagnosed with RCC between 2000 and 2016 at Stanford University Hospital, US, and Ospedale Maggiore Policlinico di Milano, Italy. Aim of the st...

ea0099p532 | Pituitary and Neuroendocrinology | ECE2024

Electronic health technologies for comprehensive acromegaly management. preliminary data from a single center experience

Carosi Giulia , Del Sindaco Giulia , Sala Elisa , Mangone Alessandra , Mungari Roberta , Cremaschi Arianna , Ferrante Emanuele , Mantovani Giovanna

Background: Acromegaly is a chronic disease which causes multiple impairments that negatively affect daily life. Telemedicine is proving to be useful in diagnosing and treating these disabling aspects, including psycho-physical comorbidities, which are difficult to investigate during conventional visits.Aim of the study: To improve the management of acromegaly, both in cured and active disease, through the use of telemedicine technologies in addition to ...

ea0099ep217 | Adrenal and Cardiovascular Endocrinology | ECE2024

Adrenal phenotype in multiple endocrine neoplasia type 1

Cremaschi Arianna , Mungari Roberta , Mangone Alessandra , Del Sindaco Giulia , Sala Elisa , Carosi Giulia , Lotito Veronica , Ferrante Emanuele , Mantovani Giovanna

Background: Adrenal involvement in multiple endocrine neoplasia type 1 (MEN1) has been reported, its prevalence varying from 9 to 73%. The aim of this study was to characterize the adrenal phenotype and the prevalence and clinical significance of cortisol hypersecretion in a cohort of MEN1 patients.Methods: We retrospectively analyzed data of 36 adult patients with germline menin mutation (20 females; mean age 50&pm;17.4 years) in regular follow-up at ou...

ea0090p679 | Pituitary and Neuroendocrinology | ECE2023

Prevalence of steatosis and organ-specific distribution of adipose tissue in patients affected by Cushing’s syndrome

Ferrante Emanuele , Oberti Giovanna , Mantovani Beatrice , Indirli Rita , Cremaschi Arianna , Sala Elisa , Carosi Giulia , Ludovica Fracanzani Anna , Mantovani Giovanna , Lombardi Rosa , Arosio Maura

Introduction: Endogenous hypercortisolism is associated with cardio-metabolic complications and promotes the deposition of lipids in different tissues, particularly in the liver. However, the prevalence of hepatic steatosis in patients with Cushing’s syndrome (CS) has been little investigated so far and only one previous study reported a prevalence of 20% using computed tomography. The aim of the study is to evaluate the prevalence of hepatic steatosis and the organ-speci...