Searchable abstracts of presentations at key conferences in endocrinology

ea0090p142 | Pituitary and Neuroendocrinology | ECE2023

Characterization of a large cohort of patients with “micromegaly”: long-term follow-up and preliminary data on treatment response

Carosi Giulia , Mangone Alessandra , Sala Elisa , Del Sindaco Giulia , Mungari Roberta , Cremaschi Arianna , Ferrante Emanuele , Arosio Maura , Mantovani Giovanna

Background: In a previous study, we retrospectively analysed a group of patients with high insulin growth factor 1 (IGF1) but normal growth hormone (GH) suppression, identifying among them a subgroup of “micromegalic” patients presenting with clinical features of acromegaly and high rate of comorbidities. We therefore expanded our cohort of patients, extended the follow-up time and collected preliminary data on treatment response aiming to better characterize this co...

ea0063p725 | Pituitary and Neuroendocrinology 2 | ECE2019

Remission rate of acromegaly after somatostatin analogs withdrawal: an update

Carosi Giulia , Sala Elisa , Sindaco Giulia Del , Verrua Elisa , Serban Andreea Liliana , Ferrante Emanuele , Arosio Maura , Mantovani Giovanna

Objective: Several studies reported that a long-time therapy with somatostatin analogs (SSTa) in acromegaly could induce persistent remission event after drug withdrawal. The aim of this study was to evaluate GH/IGF-I secretion after SSTa discontinuation in a series of acromegalic patients.Materials and methods: Data of 21 patients regularly referred to our Centre and previously included in a multicentre study, have been updated at the last available fol...

ea0063p1006 | Environment, Society and Governance | ECE2019

Telemedicine in the management of acromegalic patients

Sindaco Giulia Del , Sala Elisa , Carosi Giulia , Verrua Elisa , Serban Andreea Liliana , Ferrante Emanuele , Arosio Maura , Mantovani Giovanna

Background: In acromegalic patients, quality of life reduction and neuropsychological impairment are common, in addition to well-known complications related to the pituitary adenoma and to the GH/IGF-I excess. Acromegalic patients need a lot of outpatient visits and a multidisciplinary approach during the management of the disease and its comorbidities. Aim of the project is to analyze the role of an electronic health device (eHD) with remote monitoring in management of acrome...

ea0037ep806 | Pituitary: clinical | ECE2015

Psychological and neurocognitive evaluation in patients with pituitary adenoma

Sala Elisa , Zarino Barbara , Malchiodi Elena , Verrua Elisa , Carosi Giulia , Locatelli Marco , Rampini Paolo , Carrabba Giorgio , Spada Anna , Mantovani Giovanna

Reduced health-related quality of life (HRQoL) and impairment in neurocognitive functions are a possible complaint in patients with pituitary adenoma. Psychiatric comorbidities in Cushing’s disease are well known. However recent studies showed HRQoL reduction and psychiatric symptoms in patients with pituitary disease with or without hormonal excess. Aim of this study is to analyse HRQoL, psychiatric symptoms and neurocognitive functions in patients with pituitary adenoma...

ea0035p845 | Pituitary Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2014

NFPA and hypopituitarism: a retrospective analysis of 260 patients and focus on the prevalence of isolated hypoadrenalism

Carosi Giulia , Malchiodi Elena , Ferrante Emanuele , Sala Elisa , Verrua Elisa , Beck-Peccoz Paolo , Spada Anna , Mantovani Giovanna

Introduction: Non-functioning pituitary adenomas (NFPA) accounts for about 40% of all pituitary tumors. One or more anteropituitary deficiencies are present at diagnosis in 60–80% of NFPA. Hypopituitarism classically appears with the following order: GH→FSH/LH→TSH→ACTH. Aim of the study was to evaluate the incidence and the order of appearance of pituitary deficiencies in patients with NFPA.Materials and methods: We retrospectively...

ea0070aep694 | Pituitary and Neuroendocrinology | ECE2020

Micromegaly or acromegaly? A retrospective longitudinal study on clinical aspects and comorbidities in a large cohort of patients referred to a single tertiary center

Carosi Giulia , Sala Elisa , Mangone Alessandra , Del Sindaco Giulia , Mungari Roberta , Cremaschi Arianna , Ferrante Emanuele , Arosio Maura , Mantovani Giovanna

Introduction: The diagnosis of acromegaly is confirmed in the presence of high IGF-1 levels and inadequate suppression of growth hormone (GH) after glucose load. According to guidelines, a GH nadir (GHn)>0.4 ng/ml is considered diagnostic with ultrasensitive assays. However, some acromegalic patients with lower GHn, also called ‘micromegalic’, are reported, but a systematic collection of their clinical features is unavailable.Aim of the s...

ea0056oc11.5 | Clinical practice in endocrine tumours: combining conventional and molecular features | ECE2018

Natural history of Rathke’s Cleft Cysts: a multicenter experience

Sala Elisa , Moore Justin M , Amorin Alvaro , Carosi Giulia , Harsh Griffith R , Arosio Maura , Mantovani Giovanna , Katznelson Laurence

Objective: Rathke’s Cleft Cyst (RCC) is a common incidental type of sellar lesion, and, depending on size, may cause local mass effects with visual impairment, hypopituitarism, and headaches. In this study, we sought to define the natural history of RCC.Methods: We performed a retrospective study of patients diagnosed with RCC between 2000 and 2016 at Stanford University Hospital, US, and Ospedale Maggiore Policlinico di Milano, Italy. Aim of the st...

ea0090p679 | Pituitary and Neuroendocrinology | ECE2023

Prevalence of steatosis and organ-specific distribution of adipose tissue in patients affected by Cushing’s syndrome

Ferrante Emanuele , Oberti Giovanna , Mantovani Beatrice , Indirli Rita , Cremaschi Arianna , Sala Elisa , Carosi Giulia , Ludovica Fracanzani Anna , Mantovani Giovanna , Lombardi Rosa , Arosio Maura

Introduction: Endogenous hypercortisolism is associated with cardio-metabolic complications and promotes the deposition of lipids in different tissues, particularly in the liver. However, the prevalence of hepatic steatosis in patients with Cushing’s syndrome (CS) has been little investigated so far and only one previous study reported a prevalence of 20% using computed tomography. The aim of the study is to evaluate the prevalence of hepatic steatosis and the organ-speci...

ea0063gp236 | Anterior and Posterior Pituitary | ECE2019

Characteristics and natural history of a large cohort of non-functioning pituitary incidentalomas: a two-centers study

Betella Nazarena , Tresoldi Alberto , Carosi Giulia , Sindaco Giulia Del , Locatelli Marco , Mazziotti Gherardo , Milani Davide , Morenghi Elena , Spada Anna , Arosio Maura , Mantovani Giovanna , Lania Andrea

Context: Available data on the natural history of pituitary incidentalomas (PI) are not strong enough to draw any evidence-based conclusion on timing and length of follow up of these masses, due to heterogeneity and low sample sizes.Objective: To describe the characteristics and the natural history of PI using data from a large cohort of patients investigated in two Italian Pituitary Centers.Patients and methods: Retrospective stud...

ea0037gp.19.02 | Pituitary–Acromegaly | ECE2015

Assessment of bone quality, measured by trabecular bone score, in acromegaly

Malchiodi Elena , Sala Elisa , Verrua Elisa , Cairoli Elisa , Carosi Giulia , Ferrante Emanuele , Filopanti Marcello , Ulivieri Fabio Massimo , Eller-Vainicher Cristina , Chiodini Iacopo , Mantovani Giovanna , Spada Anna

Introduction: Acromegaly is characterised by chronic exposure to high GH and IGF1 levels that leads to increased bone turnover. Regardless of BMD value, acromegalic patients seem to have an increased vertebral fracture risk probably due to a reduction of bone quality. Trabecular bone score (TBS) is a new index used for assessing bone microarchitecture. In this study TBS was used for the first time to analyze bone quality in acromegaly.Methods: 16 new acr...