Searchable abstracts of presentations at key conferences in endocrinology

ea0035p646 | Female reproduction | ECE2014

BMP15 gene dosage as a relevant X-linked determinant of ovarian development and function

Rossetti Raffaella , Negri Irene , Castronovo Chiara , Finelli Palma , Persani Luca

The X-linked genes accounting for the determination of the ovarian function are still undefined. In the last few years, a large interest has been dedicated to the BMP15 gene. BMP15 gene encodes for a TGFβ-like growth factor of oocyte origin with a critical role in female fertility in mammals and several other species. This gene maps to a locus on the short arm of X chromosome were locates several traits of TS, including ovarian failure. Several missense variations have be...