Searchable abstracts of presentations at key conferences in endocrinology

ea0010s11 | Non classical sites of action of classical hormones | SFE2005

Actions and mechanisms of action of gonadotrophin-releasing hormone (GNRH) in non-pituitary tissue

McArdle C , Caunt C , Sedgley K , Finch A

Within the pituitary, GnRH acts via type I GnRH receptors to cause a Gq/11 mediated activation of PLC and consequent acute stimulation of gonadotrophin secretion and chronic regulation of gonadotrophin and GnRHR synthesis. The therapeutic effects of GnRH analogues are primarily (if not entirely) dependent upon activation, desensitisation or blockade of this system. There is also abundant evidence for expression of GnRHRs in extra-pituitary sites including the CNS, t...