Searchable abstracts of presentations at key conferences in endocrinology

ea0074oc4 | Oral Communications | SFENCC2021

Synchronous functional heterogeneity of metastatic pancreatic neuroendocrine tumour

Sim Sing Yang , Ramsey Emma , Cave Judith , Fityan Adam , Green Bryan , Al-Mrayat Ma'en

A 65 years old male chef presented with a history of weight loss of 15kg over a 12-month period associated with lethargy, constipation and abdominal pain. His past medical history included epilepsy, hypertension and gastric reflux. He reported no family history of endocrinopathies.At presentation his performance status was 0 and was found to have hepatomegaly. In view of rapid weight loss and hepatomegaly he had a CT scan of the abdomen and pelvis, which showed multiple hyperv...

ea0046oc2 | (1) | UKINETS2016

Tumour size is not a reliable criterion for management of patients with Non-secreting pancreatic neuroendocrine tumours: results of a large, multi-centre, operative cohort

Mills Logan , Drymousis Panagiotis , Vashist J , Burdelski C , Prachalias Andreas , Srinivasan Parthi , Menon Krishna , Khan Saboor , Cave Judith , Armstrong Thomas , Weickert MO , Frilling Andreja , Ramage JK , Srirajaskanthan Raj

Background: Small pancreatic neuroendocrine tumours (PNETs) present a management dilemma because of their uncertain natural history. Some clinicians believe that lesions <2 cm are indolent and can be managed with surveillance. By contrast, the most recent WHO classification system regards all PNETs as potentially malignant.Aim: To assess the malignant behaviour of small PNETs in a large, retrospective, multicentre patient cohort.<p class="abstext...

ea0046p17 | (1) | UKINETS2016

UK Phase IV, Observational study to assess Quality of Life in patients (pts) with pancreatic neuroendocrine tumours (pNETs) receiving treatment with Everolimus: The “Real-World” OBLIQUE Study

Ramage John , Punia Pankaj , Olusola Faluyi , Frilling Andrea , Meyer Tim , Kapur Gaurav , Cave Judith , Wadsley Johnathan , Cummins Sebastian , Farrugia David , Starling Naureen , Wall Lucy , Saharan Ruby , Valle Juan

Background: Everolimus, a mammalian target of rapamycin inhibitor, is licensed for use in adult pts with advanced well-differentiated pNETs in the UK. Limited Health-Related Quality-of-Life (HrQOL) data are available for everolimus therapy in these pts.Methods: This prospective study assessed changes in HrQoL (by monthly patient-reported EORTC QLQ-C30, -G.I.NET21 and EQ-5D questionnaires), in pts with pNETs during the first 6 months (mo) of treatment wit...

ea0080OC3 | Oral Communications | UKINETS2021

An update on the effects of debulking surgery and liver directed intra-arterial therapies on quality of life in patients with metastatic neuroendocrine tumours

Woods Eleanor , Sinclair Adam , Jarvis Emma , Ramsey Emma , Tanno Lulu , Naheed Salma , Armstrong Thomas , Takhar Arjun , Knight John , Stedman Brian , Modi Sachin , Bryant Timothy , Breen David , Nolan Luke , Al-Mrayat Ma'en , Pearce Neil , Cave Judith

Background: Neuroendocrine tumours (NETs) arise from neuroendocrine cells, they are commonly found in the pancreas, small bowel and lung. They are a heterogeneous group of tumours capable of secreting a variety of hormones, therefore the spectrum of symptoms is broad. Treatment options for metastatic NETs include cytoreductive surgery, or interventional radiology procedures such as transarterial embolization (TAE). Aims: Previous studies have shown that ...

ea0068p23 | Abstracts | UKINETS2019

Effects of debulking surgery, transarterial embolisation (TAE) and transarterial chemoembolisation (TACE) on quality of life in patients with metastatic ileal and pancreatic neuroendocrine tumours (NETs)

Sinclair Adam , Tanno Lulu , Jarvis Emma , Ramsey Emma , Naheed Salma , Armstrong Thomas , Takhar Arjun , Knight John , Stedman Brian , Modi Sachin , Bryant Timothy , Breen David , Nolan Luke , Al-Mrayat Ma'en , Pearce Neil , Cave Judith

Neuroendocrine tumours (NETs) are a heterogenous group of tumours that arise from neuroendocrine cells throughout the body. Debulking surgery is offered to patients with metastatic NETs and is recommended in the ENETS guidelines. This study was undertaken to evaluate the impact of debulking surgery and liver directed therapy (TACE, TAE) in metastatic NETs, on quality of life (QoL). Prospective longitudinal cohort study was undertaken at University Hospital Southampton. Patient...