Searchable abstracts of presentations at key conferences in endocrinology

ea0056p658 | Female Reproduction | ECE2018

Autoimmune thyroiditis and repeated pregnancy loss: a role for associated autoimmune disorders?

Virili Camilla , Cellini Miriam , Santaguida Maria Giulia , Brusca Nunzia , Stramazzo Ilaria , Gargano Lucilla , Centanni Marco

Repeated pregnancy loss (RPL), defined as two or more spontaneous abortions, may be associated with autoimmune thyroiditis (AT), either isolated or associated with polyautoimmune disorders (PD), which include antiphospholipid syndrome. An increased occurrence of RPL has been reported in patients with isolated AT but very few data are available on the influence of concurrent auto-aggressive disorders on RPL and this represented the aim of our study. A cohort of 1765 consecutive...

ea0070aep666 | Pituitary and Neuroendocrinology | ECE2020

Surgical and clinical outcome in elderly patients affected by non-functional pituitary adenoma treated by endoscopic transnasal transsphenoidal surgery: A monocentric study

Biamonte Emilia , Milani Davide , Lavezzi Elisabetta , Betella Nazarena , Cellini Miriam , Battista Lasio Giovanni , Mazziotti Gherardo , Lania Andrea

The rate of diagnosis of pituitary adenomas in the elderly is increasing, as a consequence of the improved life expectancy. The management of elderly patients affected by pituitary adenomas are still a subject of debate in literature. In particular, data on the safety of endoscopic transnasal transsphenoidal surgery (TNS) are still controversial. The primary endpoint of the present study is to assess the surgical outcome of a cohort of patients who underwent TNS for non-functi...

ea0070aep578 | Pituitary and Neuroendocrinology | ECE2020

Association between sagittal spine imbalance and radiological vertebral fractures in acromegaly: Does it reflect a pathophysiological link?

Cellini Miriam , Biamonte Emilia , Trenti Nicoletta , Mazza Massimiliano , Milani Davide , Ferrante Emanuele , Lavezzi Elisabetta , Mantovani Giovanna , Arosio Maura , Fornari Maurizio , Balzarini Luca , Lania Andrea , Mazziotti Gherardo

Chronic exposure to GH hypersecretion may alter the physiological balance of the spine through inducing degeneration of intervertebral discs and impaired trophism of facet joints. Moreover, GH in excess may also cause profound deterioration in bone microstructure with consequent increase in risk of fragility vertebral fractures (VFs). In this cross-sectional study,we evaluated for the first time in acromegaly the association between spine imbalance and VFs. Thirty-eight patien...

ea0070aep954 | Thyroid | ECE2020

TNM 8th edition in thyroid cancer staging: Is there an improvement in predicting recurrence?

Cellini Miriam , Alice Manzardo Olimpia , Indirli Rita , Dolci Alessia , Colombo Paolo , Carrone Flaminia , Lavezzi Elisabetta , Mantovani Giovanna , Mazziotti Gherardo , Arosio Maura , Lania Andrea

TNM 8th edition introduces changes in the staging of patients with differentiated thyroid carcinoma (DTC). This study aims at assessing the ability of TNM 8th edition in predicting structural recurrence of DTC.480 DTC patients were retrospectively evaluated by 7th and 8th editions of TNM staging systems in relationship with risk stratification, response to therapy and recurrence of disease as defined by 2015 American Thyroid Association (ATA) guidelines. As compared to the 7th...

ea0093oc16 | Oral communication 3: Adrenal Tumors and Neuroendocrine Tumors | EYES2023

Bone fragility in well-differentiated gastroenteropancreatic-neuroendocrine tumors: Results from a retrospective two-centered study

Brunetti Alessandro , Jaafar Simona , Chiardi Isabella , Cellini Miriam , Salcuni Antonio Stefano , Pigni Stella , Lavezzi Elisabetta , Lania Andrea , Mazziotti Gherardo , Vescini Fabio

Background: Patients affected by gastroenteropancreatic-neuroendocrine tumors (GEP-NETs) present an increased risk of bone fragility due to several factors, such as bone metastases, vitamin D deficiency, hormonal secretion, medical and surgical treatments. Although patients with well-differentiated GEP-NETs generally present a long life-expectancy, occurrence of fragility fractures could significantly impair quality of life.Objectives: The study aims to ...

ea0070aep562 | Pituitary and Neuroendocrinology | ECE2020

Treatment of acromegalic osteopathy in the real-life clinical practice: The baac (bone active drugs in acromegaly) multicenter study

Mazziotti Gherardo , Battista Claudia , Chiloiro Sabrina , Maffezzoni Filippo , Ferrante Emanuele , Grottoli Silvia , Grasso Ludovica , Gatto Federico , Olivetti Roberto , Arosio Maura , Bianchi Antonio , Carosi Giulia , Cellini Miriam , Chiodini Iacopo , De Marinis Laura , Di Somma Carolina , Ferlin Alberto , Ghigo Ezio , Lavezzi Elisabetta , Mantovani Giovanna , Pivonello Rosario , Porcelli Teresa , Prencipe Nunzia , Procopio Massimo , Scillitani Alfredo , Lania Andrea

Osteopathy is an emerging complication of acromegaly, characterized by increased bone turnover, profound abnormalities in trabecular bone structure and high risk of vertebral fractures (VFs). The therapeutic management of skeletal fragility in acromegaly is a challenge, since the risk of fractures may remain high after the control of acromegaly and the effectiveness of bone-active drugs in this clinical setting is unknown. In this retrospective-multicenter study, we aimed at e...