Endocrine Abstracts

We present a case of a 44-year-old chef, presenting with a fortnight’s history of a pruritic rash over his trunk and axillae. He was diagnosed to have hypertension, which was treated by lifestyle interventions. His diet was poor, and he drank 40 units of alcohol per week. His parents had hypercholesterolemia, but there was no history of premature coronary artery disease. On examination, his BMI was 31.62 kg/m2, and he had eruptive xanthomata on his chest, abdom...

Although double adenomas may be present in 1% of autopsy pituitaries, in patients with pituitary disease they are extremely rare. In previously reported surgical series an incidence of 0.37–1.64% has been observed. We report a 55 year old lady with features suggestive of acromegaly and a double pituitary adenoma on MRI. The diagnosis of acromegaly was confirmed by an elevated serum IGF-I and a nadir growth hormone of 10.3 mU/l during a 75 g oral glucose tolerance test. Ot...

Targets such as the ‘18 week wait’ may help reduce diagnostic and treatment delay. However, we report two cases of supposed non-classic congenital adrenal hyperplasia (CAH) that perhaps highlight the benefit of time and hindsight as diagnostic tools.Case 1 A previously unknown 61-year-old contacted our department requesting alternatives to biphosphonate therapy. ‘Mild’ CAH had been diagnosed in 1974 on the basis of elevated urinary 17...

Alterations in PTH circadian rhythmicity have previously been reported in Adult Growth Hormone Deficiency (AGHD) and may contribute to the pathogenesis of AGHD-related osteoporosis. However, changes in PTH circadian rhythm have not been correlated with bone mineral density (BMD) in AGHD. Serum phosphate is a likely determinant of PTH rhythm. We examined the PTH and phosphate circadian rhythms in AGHD patients with reduced (defined as femoral neck T-score <-1.0) and normal B...

BACKGROUND: Untreated Adult Growth Hormone Deficiency (AGHD) is associated with reduced bone mineral density (BMD). PTH plays an important role in bone metabolism and reports suggest that bone and renal target cell insensitivity to PTH may contribute to changes in bone turnover in AGHD.OBJECTIVES: To determine the difference in PTH and phosphocalcium metabolism in untreated AGHD patients who have normal and reduced BMD.METHODS: 13 ...

BACKGROUND: Adult growth hormone deficiency (AGHD) is associated with osteoporosis. Growth Hormone replacement (GHR) results in increased bone mineral density (BMD), with greater benefit derived in men. PTH plays an important role in bone metabolism and reports suggest that bone and renal insensitivity to PTH may contribute to changes in bone turnover in AGHD.OBJECTIVES: To determine the gender difference in PTH, phosphocalcium metabolism and bone turnov...