Endocrine Abstracts

Background: Giant prolactinomas are rare pituitary tumours larger than >40 mm in diameter, representing 2–3% of prolactin secreting tumours. Management is challenging especially in male patients, due to resistance to dopamine agonists (DA).Methods: Clinical, hormonal and imaging evaluation and follow-upAim: To describe a case of partially resistant giant prolactinoma in a young male patientCase repor...

Background: Genomic damage plays an important role in the pathogenesis of Type 2 Diabetes Mellitus (T2DM) and its complications. This instability increases with impaired metabolic control, and is aggravated by the presence of advance glycation-end products (AGEs) causing more cell damage. The aim of this study was to analyse the presence of genomic instability in patients with T2DM and its association with the levels of AGEs, namely glycated h...

Background: Genomic damage plays an important role in the pathogenesis of Type 2 Diabetes Mellitus (T2DM) and its complications. This instability increases with impaired metabolic control, and is aggravated by the presence of advance glycation-end products (AGEs) causing more cell damage. The aim of this study was to analyse the presence of genomic instability in patients with T2DM and its association with the levels of AGEs, namely glycated h...

Background: Immune related adverse events (iRAEs) of the endocrine system are commonly recognised in Checkpoint Inhibitor Therapy treatment with current research suggesting clinically significant endocrinopathies occur in 10%. As the use of these drugs continues to rise, so too does the importance of routine endocrine monitoring in order to avoid potentially life-threatening adverse-events.Aims: To establish the frequency, severity, management and outcom...

Thyroid cancer is the most prevalent cancer among endocrine malignancies. Surgical resection combined with radioactive iodine therapy has been proved effective in treating differentiated thyroid cancer, including papillary and follicular thyroid cancers. However, regarding metastatic poorly differentiated or anaplastic thyroid cancers, there have been no available effective treatment modalities. The genomic instability, such as chromosome aneupolidy, represents a hallmark of s...