Searchable abstracts of presentations at key conferences in endocrinology

ea0052nets2 | Speaker Abstracts | UKINETS2017

The role of pathology and the new WHO classification

Christian Adam

Neuroendocrine tumours have a number of different classification and staging systems. I will present the latest of these, which include the latest WHO system with the implications for new entities and how they are diagnosed pathologically and any difficulties that arise from this. There will also be a more general discussion about areas that are difficult for the pathologist and where we can add value to the MDT discussion....

ea0052p09 | (1) | UKINETS2017

Audit of South Wales Neuroendocrine MDT pathology reports

Peaker James , Morgan Meleri , Rees Aled , Khan Mohid , Christian Adam

The South Wales regional NET Multidisciplinary Meeting (MDT) discusses patients on a monthly basis. The European Neuroendocrine Tumour Society (ENETS) have guidance on expected pathology input into a NET MDT service. We assessed pathology reports submitted and discussed in 2016 for compliance with ENETS criteria, and determined the time from pathology reporting to MDT discussion. 117 patients had pathology submitted for review in 2016 and were assessed by one specialist NET pa...

ea0052p34 | (1) | UKINETS2017

Grading systems in gastroenteropancreatic neuroendocrine tumours

Hobby Charlotte , Morgan Meleri , Rees Aled , Khan Mohid , Christian Adam

Objective: To compare 3 methods of generating Ki-67% in gastroenteropancreatic neuroendocrine tumours (GEP-NETs).Methods: Twenty-four slides were used to generate 49 images for analysis. Each image was analysed and 3 different methods were used to calculate Ki-67%.Results: The comparison of Ki-67% from counting and estimating using the diameter (shortcut method) was strongly positively correlated, whereas the Ki-67% from counting a...

ea0068p24 | Abstracts | UKINETS2019

Improving diagnosis times as part of the transformation of the South Wales NET Service

Amin Kapish , Gruber Mei-Yin , Shayan-Arani Holleh , Taylor Rebecca , Powell Catherine , Cook Katherine , Benny Ankita , Ng Sheryl , Christian Adam , Khan Mohid S

Background: Transformation of the South Wales NET service in late 2017 introduced new specialised staff, gastroenterology-led clinics and MDTs with a particular emphasis on educating referring specialties on NETs. Data has shown patient experience, satisfaction rates, quality of life and gastrointestinal symptom scores have all improved. This study aims to describe findings from new NET service data for: referrals into the service, diagnosis times after symptoms, and initial s...

ea0052p19 | (1) | UKINETS2017

Mixed Adeno-Neuroendocrine Carcinoma (MANEC): a multicentre retrospective study

Frizziero Melissa , Wang Xin , Chakrabarty Bipasha , Childs Alexa , Luong Tu Vinh , Walter Thomas , Khan Mohid S. , Morgan Meleri , Christian Adam , Elshafie Mona , Shah Tahir , Fulford Paul , Minicozzi Annamaria , Mansoor Wasat , Meyer Tim , Hubner Richard A. , Valle Juan W. , McNamara Mairead G.

Introduction: MANEC is a rare diagnosis and little is known on its epidemiology/prognosis/management.Methods: Demographic/clinical-pathological/survival data of patients with a diagnosis of MANEC (2010 WHO criteria) from five European centres were retrospectively reviewed.Results: Sixty-six patients were identified (09/80–07/17); median age: 62.5 years (range 34–89); male: 66.7%; ECOG-PS 0-1: 59%; primary tumours from: sm...