Searchable abstracts of presentations at key conferences in endocrinology

ea0091cb60 | Additional Cases | SFEEU2023

Familial Hypocalciuric Hypercalcemia: the importance of taking detailed family history when assessing patients

Hanson Petra , Harrold Christopher

54 year south Asian woman was found to have mild hypercalcaemia of 2.64mmol/l, vitamin D of 21 nmol/land PTH of 4.9 pmol/lin 2013. She had a DEXA scan showing osteopenia of the fourth lumbar vertebrae. She did not have any symptoms suggestive of hypercalcaemia but reported generalised aches and pains. She had a past medical history of hysterectomy, right oophorectomy, dyspepsia and asthma. She was initially treated with vitamin D. Repeat calcium, vitamin D and PTH normalised a...

ea0028p2 | Bone | SFEBES2012

A case of HPT-JT syndrome with mutation involving exon 2 of CDC73 gene

Rao Ranganatha , Sivaraman Subash , Harrold Christopher , Murthy Narasimha , Sankar Sailesh

Background: Primary Hyperparathyroidism - Jaw tumour (HPT-JT) syndrome is an autosomal dominant disorder characterised by hyperparathyroidism and ossifying jaw fibromas. Inactivating germline mutations in CDC73 gene (previously known as HRPT2) is the main cause of this syndrome. There is higher incidence of parathyroid carcinoma in these individuals and also an association with other renal lesions have been described. We report a case of HPT-JT syndrome with mutation in the ex...

ea0019p187 | Endocrine tumours and neoplasia | SFEBES2009

Management of hypocalcaemia in pregnancy

Nizar Hisham , Harrold Christopher , Jones Sharon , Milles John

A 37-year-old Asian lady was diagnosed with T3 N1b Papillary carcinoma of the thyroid and operated in 1999. Post operatively she developed hypoparathyroidism and has been on regular calcium and thyroid hormone replacement.She was on her 5th pregnancy this year. She had 2 previous Caesarian sections and 1 normal vaginal delivery. She was referred to Good Hope Hospital for obstetric care & local tertiary centre for investigation of hypocalcaemia having...

ea0019p386 | Thyroid | SFEBES2009

Spurious TFT results in clinically euthyroid patients: a lesson in interference

Harrold Christopher , Nizar Hisham , Rangan S , Kennedy David , Ramachandran S

We present two cases with biochemistry results suggesting thyrotoxicosis, caused by laboratory artefacts.Case 1: A 68-year-old male with type 2 diabetes was referred with weight loss. Results showed fT4 of 30.5 and TSH of 1.07, confirmed on repeat. He had no symptoms of hyperthyroidism.Blood was sent for treatment with antibody-blocking reagents:...

ea0028p100 | Clinical practice/governance and case reports | SFEBES2012

A case of unrecognized maternal PTH resistance and severe impact on neonatal bone mineralisation

Sivaraman Subash , Rao Ranganath , Murthy Narasimha , Weickhert Mi , Randeva Hs , Sankaranarayanan Sailesh , Harrold Christopher

A 25 year old lady was referred to the endocrine clinic after her newborn baby was noted to have respiratory problems, marked osteopenia and hypocalcemia. Further investigations on the mother showed corrected calcium of 1.11 mmol/L; however she was relatively asymptomatic. Reviewing her history in detail, she was born in Nigeria and moved to the UK 2 years prior to the presentation. She used to get intermittent cramps in her hands, legs and body since the age of 10 in addition...

ea0094p330 | Bone and Calcium | SFEBES2023

Retrospective audit on biochemical, radiological investigations done prior to Parathyroidectomy for Primary Hyperparathyroidism

Kumar Sheethal , Abdulrahim Emad , Elena-Singh Andrada , Jones Bethany , Chauhan Rajveer , Natesh Basavaiah , Harrold Christopher , Howe David , Pratibha Machenahalli C

As per NICE guideline, referral for parathyroidectomy need to be according the below, • symptoms of hypercalcaemia or • End-organ disease (renal stones, fragility fractures or osteoporosis) or • An albumin-adjusted serum calcium level of 2.85 mmol/litre or above.Methods: We conducted a retrospective analysis of investigations done as per recommendation of NICE guidelines for patients who underwent Parathyroidectomy under t...