Searchable abstracts of presentations at key conferences in endocrinology

ea0090p539 | Late-Breaking | ECE2023

Somatic RET M918T variant can modify the natural history of MEN2 related medullary thyroid carcinoma: a case report and literature review

Sahakian Nicolas , Romanet Pauline , Cinzia Paladino Nunzia , Mirebeau-Prunier Delphine , Castinetti Frederic , Barlier Anne

Background: Multiple endocrine neoplasia type 2 associated medullary thyroid carcinoma (MTC) is driven by a strong genotype-phenotype correlation, the risk of aggressiveness being defined by the germline RET pathogenic variant (American Thyroid Association (ATA) guidelines). Based on this classification, the germline c.2370G>C, p.Leu790Phe (L790F) RET variant is considered to be of moderate risk of aggressive MTC, while the germline c.2753T>C, p.Met918Thr (M9...