Searchable abstracts of presentations at key conferences in endocrinology

ea0041gp185 | Reproduction & Endocrine Disruption | ECE2016

Human Chorionic Gonadotropin supports Treg-mediated fetal protection in mice by modulating DC phenotype

Schumacher Anne , Sporke Dominique , Ehrentraut Stefanie , Claudia Zenclussen Ana

Introduction: Human Chorionic Gonadotropin (hCG) contributes to fetal tolerance by regulating innate and adaptive immune responses during pregnancy. Our previous results suggested a pregnancy protective effect of hCG through enhancement of regulatory T (Treg) cells and inhibition of dendritic cell (DC) maturation. Here, we aimed to investigate whether hCG contributes to Treg generation by modulating DC phenotype in vitro and in vivo in a murine model.<p c...

ea0014s16.3 | Immune-endocrine turmoil of pregnancy | ECE2007

Regulatory T cells in pregnancy

Claudia Zenclussen Ana , Rau Juliane , Thuere Catharina , Schumacher Anne , Zimmermann Gerolf , Volk Hans-Dieter , Alexander Henry

The survival of the semiallogeneic fetus within the mother is thought to be due to mechanisms of immunological tolerance. Regulatory T cells (Treg) are believed to have a crucial role in maintaining pregnancy by creating a transient tolerant microenvironment within the maternal uterus as former studies confirmed. We have evidences that Treg expand in lymph nodes from normal pregnant mice already on day 2 of pregnancy. Abortion-prone mice present diminished numbers of Treg in i...