Searchable abstracts of presentations at key conferences in endocrinology
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18th European Congress of Endocrinology

Guided Posters

Reproduction & Endocrine Disruption

ea0041gp179 | Reproduction & Endocrine Disruption | ECE2016

Urinary bisphenol A in PCOS women and its relation to steroid hormones

Lazurova Zora , Hubkova Beata , Marekova Maria , Figurova Jana , Lazurova Ivica

Bisphenol A (BPA) is an environmental estrogen found in plastic material such as bottles, food package, dental material, etc. It is known to have many negative effects on human health and its exposure is associated with endocrine disorders including polycystic ovary syndrome (PCOS). Some studies found significantly higher serum and urinary levels of BPA in PCOS women, however its association with steroid hormones is still controversial.Aim: The aim of th...

ea0041gp180 | Reproduction & Endocrine Disruption | ECE2016

An estrogen receptor-dependent pathway is involved in fludioxonil-induced cancer growth and metastasis linked with epithelial mesenchymal transition in cellular and xenografted ovarian cancer models

Kim Cho-Won , Go Ryeo-Eun , Choi Kyung-Chul

Fludioxonil is an antifungal agent used in agricultural applications that is present at measurable amounts in fruits and vegetables. In this study, the effects of fludioxonil on cancer cell viability, epithelial-mesenchymal transition (EMT) and metastasis were examined in BG-1 ovarian cancer cells with estrogen receptors (ERs). BG-1 cells were cultured with 0.1% DMSO (control), 17β-estradiol (E2; 1×10−9 M), or fludioxonil (10−5&#8722...

ea0041gp181 | Reproduction & Endocrine Disruption | ECE2016

Metformin directly alters key glycolytic enzyme protein expression and mitochondrial function in the endometria of PCOS patients

Shao Ruijin , Li Xin , Billig Hakan

Polycystic ovary syndrome (PCOS) is a significant risk factor for the development and progression of type I endometrial cancer (EC). Currently, it is not known whether metformin has a direct effect on the endometria and further regulates glycolysis and mitochondrial function in PCOS patients with endometrial hyperplasia and carcinoma. Here we show that endometria from PCOS patients with endometrial hyperplasia and carcinoma have a distinct protein expression pattern of glycoly...

ea0041gp182 | Reproduction & Endocrine Disruption | ECE2016

Elevated circulating levels of betatrophin are associated with polycystic ovary syndrome

Calan Mehmet , Yilmaz Ozgur , Kume Tuncay , Unal Kocabas Gokcen , Yesil Senses Pinar , Mehmet Senses Yasar , Temur Muzaffer , Gursoy Calan Ozlem

Context: Betatrophin is a newly identified hormone appreciated for its role as a potent inducer of beta cell proliferation in line with insulin resistance in mice. Polycystic ovary syndrome (PCOS) is an inflammatory-based metabolic disease associated with insulin resistance. However, no evidence was available whether betatrophin is involved in women with PCOS.Objective: To ascertain whether betatrophin levels are altered in women with PCOS.<p class="...

ea0041gp183 | Reproduction &amp; Endocrine Disruption | ECE2016

Intima media thickness and brachial artery flow mediated dilatation in women with polycystic ovary syndrome and type 1 diabetes mellitus

Lebkowska Agnieszka , Adamska Agnieszka , Tolwinska Joanna , Jacewicz Malgorzata , Hryniewicka Justyna , Milewski Robert , Wolczynski Slawomir , Bossowski Artur , Gorska Maria , Kowalska Irina

Polycystic ovary syndrome (PCOS) and type 1 diabetes (T1DM) are accompanied by increased risk of atherosclerosis. A higher prevalence of PCOS in T1DM patients has been reported. Brachial artery flow-mediated dilatation (FMD) and intima media thickness of common carotid artery (IMT) are used to detect an early endothelial dysfunction.The aim of our study was to examine IMT and FMD in T1DM women with PCOS. We also estimated the relation of IMT and FMD to c...

ea0041gp184 | Reproduction &amp; Endocrine Disruption | ECE2016

Impaired DHEA sulfation defines androgen excess in women with polycystic ovarian syndrome (PCOS)

Kempegowda Punith , O'Reilly Michael W , Hassan-Smith Zaki , Storbeck Karl-Heinz , Taylor Angela E , Arlt Wiebke

Context: Polycystic ovarian syndrome (PCOS) is the most common endocrine disorder in women of classic androgen synthesis. Recent work has highlighted that impaired DHEA sulfation results in enhanced androgen production. Here, we evaluated the relationship between DHEA and DHEAS and androgen excess and metabolic phenotype in PCOS.Patients and methods: We compared 65 women with PCOS to 35 healthy women matched for age and body mass index (BMI). All subject...

ea0041gp185 | Reproduction &amp; Endocrine Disruption | ECE2016

Human Chorionic Gonadotropin supports Treg-mediated fetal protection in mice by modulating DC phenotype

Schumacher Anne , Sporke Dominique , Ehrentraut Stefanie , Claudia Zenclussen Ana

Introduction: Human Chorionic Gonadotropin (hCG) contributes to fetal tolerance by regulating innate and adaptive immune responses during pregnancy. Our previous results suggested a pregnancy protective effect of hCG through enhancement of regulatory T (Treg) cells and inhibition of dendritic cell (DC) maturation. Here, we aimed to investigate whether hCG contributes to Treg generation by modulating DC phenotype in vitro and in vivo in a murine model.<p c...

ea0041gp186 | Reproduction &amp; Endocrine Disruption | ECE2016

FSH increases the different LH- and hCG-dependent intracellular signalling and the downstream life/death signals in vitro

Casarini Livio , Riccetti Laura , De Pascali Francesco , Nicoli Alessia , Tagliavini Simonetta , Trenti Tommaso , Battista La Sala Giovanni , Simoni Manuela

Background: Luteinizing hormone (LH) and choriogonadotropin (hCG) are glycoprotein hormones regulating ovarian function and pregnancy. They were routinely used in assisted reproduction techniques (ART) assuming they are equivalent, due to their binding to a common receptor (LHCGR). However, differences between LH and hCG were demonstrated at molecular and physiological level.Aim: The aim of this study is to evaluate how follicle-stimulating hormone (FSH)...

ea0041gp187 | Reproduction &amp; Endocrine Disruption | ECE2016

Testosterone supplementation and body composition: results from a meta-analysis of observational studies

Corona Giovanni , Giagulli Vito A , Maseroli Elisa , Vignozzi Linda , Aversa Antonio , Zitzmann Michael , Saad Farid , Maggi Mario

Background: The concept of testosterone (T) supplementation (TS) as a new anti-obesity medication in men with testosterone deficiency syndrome (TDS) is emerging.Aim: To systematically review and meta-analyze available observational and register studies reporting data on body composition in studies on TS in TDS.Methods: An extensive Medline Embase and Cochrane search was performed including the following words: ‘testosterone&#1...

ea0041gp188 | Reproduction &amp; Endocrine Disruption | ECE2016

Human 3β-hydroxysteroid dehydrogenase deficiency associated with a normal spermatic numeration despite a severe enzyme deficit, after an accomplished transition period

Donadille Bruno , Cabrol Sylvie , Houang Muriel , Lebouc Yves , Morel Yves , Netchine Irene , Christin-Maitre Sophie

Human 3β-hydroxysteroid dehydrogenase deficiency is a rare form of congenital adrenal hyperplasia resulting from HSD3B2 gene mutations, leading to steroidogenesis impairment in both adrenals and gonads. The transition period is important for a successful adult fertility, but information about fertility is lacking in this rare disease.The patient presented with salt wasting at birth in Trousseau Hospital. Consanguinity was present, since the parents ...