Endocrine Abstracts

Before the development of purified insulin in the 1970s, lipoatrophy was a common complication of insulin therapy (1–2). With the arrival of human insulin, lipoatrophy, becoming a rare problem in clinical practice.Lipoatrophies are considered an adverse immunological side effect of insulin therapy, and in some cases they are mediated by a local high production of tumour necrosis factor-α, w...