Searchable abstracts of presentations at key conferences in endocrinology

ea0070aep534 | Endocrine-related Cancer | ECE2020

Diverse regulation of HIF-1 on VEGF in renal cell carcinoma

Beleslin Cokic Bojana , Damjanovic Svetozar , Bizic Radulovic Sandra , Suboticki Tijana , Cokic Vladan , Milicevic Ivana , Rodic Gordana , Antic Jadranka , Macut Djuro

The clear cell renal cell carcinoma (ccRCC) can be sporadic or familiar, with the mutated von Hippel-Lindau (VHL) gene. The inactive VHL protein prevents degradation of hypoxia inducible factor (HIF) that promotes overexpression of angiogenic factors such as vascular endothelial growth factor (VEGF) and erythropoietin (EPO). Sequencing and multiplex ligation-dependent probe amplification (MLPA) of VHL gene in 43 samples of ccRCC in tumors vs surrounding healthy tissues reveale...