Endocrine Abstracts

After bromocriptine withdrawal recurrence rates of >90% in patients with macroprolac-tinomas and >80% in those with microprolactinomas have been reported, but follow-up studies were too short to permit definitive conclusions. No systematic data on cabergoline withdrawal are currently available nor have criteria for withdrawal been established. To investigate the success rate of cabergoline withdrawal in patients with non-tumoral hyperprolactinemia (NTH), microprolactinom...

Authored 500+ peer reviewed publications. Her current areas of research include molecular basis and clinical treatment of tumors in the region of the hypothalamus-pituitary and neuroendocrine tumors. Consequences of deficiency and excess of GH and IGF-I on the cardiovascular system. Endocrine consequences in survivors of malignant neoplasia. Insulin resistance and cancer. Secondary osteoporosis. Endocrine consequences of bariatric surgery in obesity. She is affiliated with num...

Surgery is the first-line treatment of patients with clinically non-functioning pituitary adenomas (NFA). Because of lack of clinical syndrome these tumours are diagnosed with a variable delay when patients suffer from compression symptoms (hypopituitarism, headache, visual field defects) due to the extension of the tumour outside the pituitary fossa. Surgery is followed by residual tumour tissue in most patients. In these cases, radiotherapy is generally used to prevent tumou...

Recent epidemiological evidence suggests that low-normal levels of serum IGF-I are associated with increased risk of acute myocardial infarction, ischemic heart disease, coronary and carotid artery atherosclerosis.The IGF-I system is involved in the regulation of cardiovascular physiopathology: it has a physiological role in regulating glucose, protein and lipid metabolism, and in promoting proliferation, differentiation and migration of many cell types....

A-M Colao, University Federico II of Naples, Naples, Italy. AbstractDr Annamaria Colao has been involved in clinical laboratory research since 1980 as a student in Medicine. At that time, she entered into the study group of hypothalamus-pituitary tumours and was mentored by Dr Gaetano Lombardi. Since that time, her publications and research have focused on pituitary tumours, especially prolactinomas and acromegaly. Bes...

Background & Methods: Occasional case reports of individual patients with scalp hairloss while receiving somatostatin analogues for acromegaly led us to audit similar patients in our departments.Results: Ten patients (four men, mean age at diagnosis 44.7years [range 26-65years]) who have received somatostatin analogues either initially as primary therapy (50%) or as post-surgical treatment (50%) for uncured acromegaly reported significant scalp hair...

Chronotype is defined as a trait determining the subject circadian preference in behavioral and biological rhythms relative to external light-dark cycle.The morning chronotype (MC) prefers activities earlier in the day, while the evening chronotype (EC) perform its main activity late in the day. Intermediate chronotype (IC) is in an intermediate position between MC and EC. EC as well as menopause have been associated to an increased risk of cardiometabolic diseases (CMD) in ob...

Background: Polycystic Ovary syndrome (PCOS) is the most common endocrine disorders in women of reproductive age whose lifestyle approach is an essential part of the treatment. Recently chronotype, i.e. a trait that determines individual’s circadian preference in behavioral and biological rhythms, has been reported to play a role in determining nutrition preferences and the risk of developing chronic diseases. Thus, the aim of the study was to investigate if chronotype ca...

Very Low-Calorie Ketogenic Diet (VLCKD) is currently a promising approach for the treatment of obesity. However, little is known about the side effects since most of the studies reporting them were carried out in normal weight subjects following ketogenic diet for other purposes than obesity. Thus, the aims of the study were: 1) to investigate the safety of VLCKD in subjects with obesity; 2) if VLCKD-related side effects could have an impact on its efficacy. In this prospectiv...

Background: Multiple endocrine neoplasia type 1 (MEN1), is an autosomal dominant inherited disorder with high penentrance, characterized by the onset of multiple tumors, mainly in parathyroid, pituitary gland and gastroenteropancreatic tract. During the course of the disease pituitary adenomas (PA) occur in 20-65%, rarely as first clinical manifestation, and are often described as larger, more aggressive, and more resistant to conventional therapy than their sporadic counterpa...