Searchable abstracts of presentations at key conferences in endocrinology

ea0021p348 | Steroids | SFEBES2009

−344 C/T polymorphism of aldosterone synthase gene (CYP11B2) and cortisol synthesis in heart failure patients

Tsorlalis Ioannis , Fraser Robert , Jackson Colette , Ingram Mary , Holloway Christine , McMurray John , Connell John

Background: Increased levels of cortisol are associated with worse prognosis in heart failure (HF). The final step in cortisol production is catalysed by 11β-hydroxylase encoded by CYP11B1, which is highly homologous with CYP11B2. A common polymorphism in the aldosterone synthase gene (CYP11B2 −344T) is associated with a raised ratio of 11-deoxycortisol/ cortisol (S/F). We examined the relationship between −344C/T polymorphism and corticos...